Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Andrew S. Truong"'
Autor:
Mi Zhou, Bhavani Krishnan, Sean T. Bailey, Takanobu Utsumi, Christof C. Smith, Lisa M. Bixby, William Y. Kim, Andrew S. Truong, Ujjawal Manocha, Matthew I. Milowsky, Wolfgang Beck, Sara E. Wobker, Benjamin G. Vincent, Kyle G. Stewart, Xiaping He, Charles M. Perou, Tracy L. Rose
Publikováno v:
Journal of Clinical Investigation. 131
Although immune-checkpoint inhibitors (ICIs) have been a remarkable advancement in bladder cancer treatment, the response rate to single-agent ICIs remains suboptimal. There has been substantial interest in the use of epigenetic agents to enhance ICI
Autor:
Andrew S. Truong, Mi Zhou, Michael S. Sturdivant, John D. Raupp, Ujjawal Manocha, William Y. Kim
Publikováno v:
Cancer Research. 82:919-919
Bladder cancer is the sixth most common type of cancer in the United States. In 2021, there are an estimated 83,730 new cases and 17,200 deaths from bladder cancer. Only about 15% of patients with metastatic disease survive past five years. The apoli
Autor:
Michael J. Emanuele, Anthony Arceci, Yanqiong Zhang, Xianxi Wang, Rajarshi Choudhury, Thomas Bonacci, Andrew S. Truong, Jennifer L. Kernan, Christine A. Mills, Pengda Liu
Publikováno v:
Cell Reports, Vol 20, Iss 13, Pp 3212-3222 (2017)
The oncogenic AKT kinase is a key regulator of apoptosis, cell growth, and cell-cycle progression. Despite its important role in proliferation, it remains largely unknown how AKT is mechanistically linked to the cell cycle. We show here that cyclin F
Publikováno v:
The Analyst. 141:661-668
Cellular migration is the movement of cells, cultured as a monolayer; cellular invasion is similar to migration, but requires the cells to move through a three-dimensional material such as basement membrane extract or a synthetic hydrogel. Migration
Autor:
Matthew R. Lockett, Andrew S. Truong
Publikováno v:
The Analyst. 141:3874-3882
Low oxygen tension, or hypoxia, is a common occurrence in solid tumors. Hypoxia is a master regulator of cellular phenotype, and is associated with increased tumor invasion and aggressiveness as well as adverse patient prognosis. Oxygen has recently
Publikováno v:
Analytical and Bioanalytical Chemistry. 408:2985-2992
Paper-based scaffolds are an attractive material for generating 3D tissue-like cultures because paper is readily available and does not require specialized equipment to pattern, cut, or use. By controlling the exchange of fresh culture medium with th
Autor:
Bhavani Krishnan, Ujjawal Manocha, Andrew S. Truong, Takanobu Utsumi, Kyle G. Stewart, Ryoichi Saito, Sean T. Bailey, William Y. Kim, Mi Zhou
Publikováno v:
Clinical Cancer Research. 26:A13-A13
Bladder cancer harbors a high frequency of somatic mutations that occur randomly across the genome. A fraction of these mutations can be expressed and processed into peptides called neoantigens. When presented on the surface of tumor cells by the maj
Autor:
Mi Zhou, Sean T. Bailey, Bhavani Krishnan, Ryoichi Saito, William Y. Kim, Ujjawal Manocha, Jordan Kardos, Kyle G. Stewart, Andrew S. Truong
Publikováno v:
Cancer Research. 78:2748-2748
Aberrant chromatin remodeling by epigenetic modifier proteins such as histone deacetylases (HDACs) is common within many types of cancer, including muscle-invasive bladder cancer (MIBC). The removal of acetyl groups from the lysine residues of histon
Autor:
Bhavani Krishnan, Andrew S. Truong, Benjamin G. Vincent, Jordan Kardos, Kyle G. Stewart, Lisa M. Bixby, William Y. Kim
Publikováno v:
Cancer Research. 78:2749-2749
In patients with bladder cancer, programmed death-ligand-1 (PD-L1) and programmed death-1 (PD-1) inhibitors have been shown to be effective in around twenty percent of patients, and there is evidence indicating that the level of immune infiltration a
Publikováno v:
Analytical chemistry. 87(22)
Paper-based scaffolds are an attractive material for culturing mammalian cells in a three-dimensional environment. There are a number of previously published studies, which utilize these scaffolds to generate models of aortic valves, cardiac ischemia