Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Andrew S. Tasker"'
Autor:
E Allen Sickmier, Robert J M Kurzeja, Klaus Michelsen, Mukta Vazir, Evelyn Yang, Andrew S Tasker
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163366 (2016)
Panitumumab and cetuximab target the epidermal growth factor receptor for the treatment of metastatic colorectal cancer. These therapies provide a significant survival benefit to patients with metastatic colorectal cancer with wild-type RAS. A single
Externí odkaz:
https://doaj.org/article/9714291c953e4ed38fccb50a2c3b5208
Autor:
Hui-Ling Wang, Kristin L. Andrews, Shon K. Booker, Jude Canon, Victor J. Cee, Frank Chavez, Yuping Chen, Heather Eastwood, Nadia Guerrero, Brad Herberich, Dean Hickman, Brian A. Lanman, Jimmy Laszlo, Matthew R. Lee, J. Russell Lipford, Bethany Mattson, Christopher Mohr, Yen Nguyen, Mark H. Norman, Liping H. Pettus, David Powers, Anthony B. Reed, Karen Rex, Christine Sastri, Nuria Tamayo, Paul Wang, Jeffrey T. Winston, Bin Wu, Qiong Wu, Tian Wu, Ryan P. Wurz, Yang Xu, Yihong Zhou, Andrew S. Tasker
Publikováno v:
Journal of Medicinal Chemistry. 62:1523-1540
Pim kinases are a family of constitutively active serine/threonine kinases that are partially redundant and regulate multiple pathways important for cell growth and survival. In human disease, high expression of the three Pim isoforms has been implic
Autor:
Lewis D, Pennington, Michael D, Croghan, Kelvin K C, Sham, Alexander J, Pickrell, Paul E, Harrington, Michael J, Frohn, Brian A, Lanman, Anthony B, Reed, Matthew R, Lee, Han, Xu, Michele, McElvain, Yang, Xu, Xuxia, Zhang, Michael, Fiorino, Michelle, Horner, Henry G, Morrison, Heather A, Arnett, Christopher, Fotsch, Andrew S, Tasker, Min, Wong, Victor J, Cee
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(1)
We reveal how a N-scan SAR strategy (systematic substitution of each CH group with a N atom) was employed for quinolinone-based S1P(1) agonist 5 to modulate physicochemical properties and optimize in vitro and in vivo activity. The diaza-analog 17 di
Autor:
Liping H, Pettus, Ryan P, Wurz, Shimin, Xu, Brad, Herberich, Bradley, Henkle, Qiurong, Liu, Helen J, McBride, Sharon, Mu, Matthew H, Plant, Christiaan J M, Saris, Lisa, Sherman, Lu Min, Wong, Samer, Chmait, Matthew R, Lee, Christopher, Mohr, Faye, Hsieh, Andrew S, Tasker
Publikováno v:
Journal of medicinal chemistry. 53(7)
The p38alpha mitogen-activated protein (MAP) kinase is a central signaling molecule in many proinflammatory pathways, regulating the cellular response to a multitude of external stimuli including heat, ultraviolet radiation, osmotic shock, and a vari
Autor:
Ryan P. Wurz, Liping H. Pettus, Bradley Henkle, Lisa Sherman, Matthew Plant, Kent Miner, Helen J. McBride, Lu Min Wong, Christiaan J.M. Saris, Matthew R. Lee, Samer Chmait, Christopher Mohr, Faye Hsieh, Andrew S. Tasker
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(5)
A novel class of pyrazolopyridazine p38alpha mitogen-activated protein kinase (MAPK) inhibitors is disclosed. A structure activity relationship (SAR) investigation was conducted driven by the ability of these compounds to inhibit the p38alpha enzyme,
Autor:
Ning, Xi, Stephen, Arvedson, Shawn, Eisenberg, Nianhe, Han, Michael, Handley, Liang, Huang, Qi, Huang, Alexander, Kiselyov, Qingyian, Liu, Yuelie, Lu, Gladys, Nunez, Timothy, Osslund, David, Powers, Andrew S, Tasker, Ling, Wang, Tingjian, Xiang, Shimin, Xu, Jiandong, Zhang, Jiawang, Zhu, Richard, Kendall, Celia, Dominguez
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(11)
Novel alphavbeta3 antagonists based on the N-aryl-gamma-lactam scaffold were prepared. SAR studies led to the identification of potent antagonists for alphavbeta3 receptor with excellent selectivity against the structurally related alpha(IIb)beta3 re
Publikováno v:
Journal of the American Chemical Society. 113:670-672
Autor:
Andrew S. Tasker, David M. Pollock
Publikováno v:
Endothelin Receptors and Signaling Mechanisms ISBN: 9783662116746
Multiple receptor subtypes for endothelin have been identified in pharmacological studies both in vitro and in vivo. As can be evidenced in the study by Yanagisawa et al, at least two receptor subtypes may be responsible for the biphasic nature of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0be3555b0a99b63f048cb5fa19d6312e
https://doi.org/10.1007/978-3-662-11672-2_2
https://doi.org/10.1007/978-3-662-11672-2_2
Autor:
Noel D. D’Angelo, Steven F. Bellon, Shon K. Booker, Yuan Cheng, Angela Coxon, Celia Dominguez, Ingrid Fellows, Douglas Hoffman, Randall Hungate, Paula Kaplan-Lefko, Matthew R. Lee, Chun Li, Longbin Liu, Elizabeth Rainbeau, Paul J. Reider, Karen Rex, Aaron Siegmund, Yaxiong Sun, Andrew S. Tasker, Ning Xi
Publikováno v:
Journal of Medicinal Chemistry; Aug2008, Vol. 51 Issue 18, p5766-5779, 14p
Publikováno v:
Journal of the Chemical Society, Chemical Communications. :763
The synthesis of tetracyclic ketone 21, a key intermediate in the total synthesis of the alkaloid gelsemie, is described.