Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Andrew S. Goldsborough"'
Autor:
Keith J. M. Moore, Jeremy Cahill, Guy Aidelberg, Rachel Aronoff, Ali Bektaş, Daniela Bezdan, Daniel J. Butler, Sridar V. Chittur, Martin Codyre, Fernan Federici, Nathan A. Tanner, Scott W. Tighe, Randy True, Sarah B. Ware, Anne L. Wyllie, Evan E. Afshin, Andres Bendesky, Connie B. Chang, Richard Dela Rosa, Eran Elhaik, David Erickson, Andrew S. Goldsborough, George Grills, Kathrin Hadasch, Andrew Hayden, Seong-Young Her, Julie A. Karl, Chang Hee Kim, Alison J. Kriegel, Thomas Kunstman, Zeph Landau, Kevin Land, Bradley W. Langhorst, Ariel B. Lindner, Benjamin E. Mayer, Lee A. McLaughlin, Matthew T. McLaughlin, Jenny Molloy, Christopher Mozsary, Jerry L. Nadler, Melinee D'Silva, David Ng, David H. O'Connor, Jerry E. Ongerth, Olayinka Osuolale, Ana Pinharanda, Dennis Plenker, Ravi Ranjan, Michael Rosbash, Assaf Rotem, Jacob Segarra, Stephan Schürer, Scott Sherrill-Mix, Helena Solo-Gabriele, Shaina To, Merly C. Vogt, Albert D. Yu, Christopher E. Mason
Publikováno v:
J Biomol Tech
As the second year of the COVID-19 pandemic begins, it remains clear that a massive increase in the ability to test for SARS-CoV-2 infections in a myriad of settings is critical to controlling the pandemic and to preparing for future outbreaks. The c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcc7049220c378abd20bf95f74cd84ab
https://pubmed.ncbi.nlm.nih.gov/35136384
https://pubmed.ncbi.nlm.nih.gov/35136384
Autor:
Matthew D. Hall, Travis S. Marshall, Alexandra D.T. Kwit, Lisa M. Miller Jenkins, Andrés E. Dulcey, James P. Madigan, Kristen M. Pluchino, Andrew S. Goldsborough, Kyle R. Brimacombe, Gary L. Griffiths, Michael M. Gottesman
Publikováno v:
The Journal of biological chemistry. 295(13)
Background: Tiopronin is a small molecule that selectively kills multidrug-resistant cancer cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6022585519181ab6e68441681474bd81
https://pubmed.ncbi.nlm.nih.gov/24930045
https://pubmed.ncbi.nlm.nih.gov/24930045
Autor:
Andrés E. Dulcey, Lisa M. Miller Jenkins, Alexandra D.T. Kwit, Kyle R. Brimacombe, James P. Madigan, Gary L. Griffiths, Kristen M. Pluchino, Andrew S. Goldsborough, Michael M. Gottesman, Matthew D. Hall, Travis S. Marshall
Publikováno v:
Journal of Biological Chemistry. 289:21473-21489
Multidrug resistance (MDR) is a major obstacle to the successful chemotherapy of cancer. MDR is often the result of overexpression of ATP-binding cassette transporters following chemotherapy. A common ATP-binding cassette transporter that is overexpr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1661887467cd5a095a9033e5e0b5c8e6
https://doi.org/10.1074/jbc.m114.581702
https://doi.org/10.1074/jbc.m114.581702
Autor:
Pavitra Kannan, Andrés E. Dulcey, Gary L. Griffiths, Michael M Gottesman, Kristen M. Pluchino, Andrew S. Goldsborough, Misty D. Handley, Matthew D. Hall, Kyle R. Brimacombe
Publikováno v:
Journal of Medicinal Chemistry. 54:4987-4997
A major challenge in the treatment of cancer is multidrug resistance (MDR) that develops during chemotherapy. Here we demonstrate that tiopronin (1), a thiol-substituted N-propanoylglycine derivative, was selectively toxic to a series of cell lines e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2296ed09285659b272d913ebd801e362
https://doi.org/10.1021/jm2001663
https://doi.org/10.1021/jm2001663
Publikováno v:
Biochemical and Biophysical Research Communications
Biochemical and Biophysical Research Communications, Elsevier, 2008, 374 (1), pp.44-48. ⟨10.1016/j.bbrc.2008.06.094⟩
Biochemical and Biophysical Research Communications, Elsevier, 2008, 374 (1), pp.44-48. ⟨10.1016/j.bbrc.2008.06.094⟩
Neurodegenerative disorders such as Alzheimer's, Huntington's, and prion diseases are characterized by abnormal protein deposits in the brain of affected patients. In prion diseases, a key event in the pathogenesis is the conversion of the normal pri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baec54a8529fc90bb509203702374c24
https://doi.org/10.1016/j.bbrc.2008.06.094
https://doi.org/10.1016/j.bbrc.2008.06.094
Autor:
T. Lavabre-Bertrand, J. Demaille, J F Rossi, M. Dupont, T. Levayer, J M Rey, Andrew S. Goldsborough, J. Savare
Publikováno v:
BioTechniques. 33:158-164
The detection of chimeric transcripts derived from aberrant chromosomal fusion events provides an exceptionally valuable tool for the diagnosis of leukemia. We have developed a simple, inexpensive, reproducible, and automated method to quantify RT-PC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9940423cbee5a39f8b84094c732777f9
https://doi.org/10.2144/02331md04
https://doi.org/10.2144/02331md04
Publikováno v:
Nature. 381:807-810
The interactions between enhancers and promotor elements that control gene expression are generally considered to act in cis only, but genetic studies suggest that they can also function in trans between non-contiguous DNA molecules. Termed transvect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::390b18a8566d0b76b8b6a2f9fb90fe1a
https://doi.org/10.1038/381807a0
https://doi.org/10.1038/381807a0
Publikováno v:
Genetics. 142:893-906
We isolated and characterized numerous engrailed and invected alleles. Among the deficiencies we isolated, a mutant lacking invected sequences was viable and phenotypically normal, a mutant lacking engrailed was an embryo lethal and had slight segmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9ae9ad7a3952dfb8de4dc92f8300c7e
https://doi.org/10.1093/genetics/142.3.893
https://doi.org/10.1093/genetics/142.3.893
Autor:
Michael M. Gottesman, Kristen M. Pluchino, Richard Callaghan, Andrew S. Goldsborough, Matthew D. Hall
While chemotherapy remains the most effective treatment for disseminated tumors, acquired or intrinsic drug resistance accounts for approximately 90% of treatment failure. Multidrug resistance (MDR), the simultaneous resistance to drugs that differ b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59b798831733c4b41efd8114e4add9a7
https://europepmc.org/articles/PMC3348266/
https://europepmc.org/articles/PMC3348266/
Publikováno v:
Proceedings of the National Academy of Sciences. 91:12696-12700
Changes in levels of transcription can be difficult to gauge in animals with lethal mutations. For example, mutations in a regulatory region of an essential gene can have secondary consequences that complicate attempts to quantify the transcripts pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2ebd8945b48cbe972d85b461368c4f8
https://doi.org/10.1073/pnas.91.26.12696
https://doi.org/10.1073/pnas.91.26.12696