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pro vyhledávání: '"Andrew S Lampert"'
Publikováno v:
ASN Neuro, Vol 7 (2015)
Intracerebral hemorrhage (ICH) is a devastating type of stroke characterized by bleeding into the brain parenchyma and secondary brain injury resulting from strong neuroinflammatory responses to blood components. Production of prostaglandin E 2 (PGE
Externí odkaz:
https://doaj.org/article/0cfb9bbc90f84467a2fa5445ea00c742
Autor:
Matthew A. Diller, Jenna L Leclerc, Andrew S Lampert, Chris Li, Emanuela Tolosano, Claudia Loyola Amador, Sylvain Doré, Stacy Jean
Publikováno v:
Exp Neurol
Intracerebral hemorrhage (ICH) is a devastating stroke subtype and the presence of extracorpuscular hemoglobin (Hb) exacerbates brain damage. Haptoglobin (Hp) binds Hb, which prevents its oxidation and participation in neurotoxic reactions. Multiple
Autor:
Jenna L Leclerc, Andrew S Lampert, Søren K. Moestrup, Terrie Vasilopoulos, Pia Svendsen, Claudia Loyola Amador, Brandon Schlakman, Sylvain Doré
Publikováno v:
Leclerc, J L, Lampert, A S, Loyola Amador, C, Schlakman, B, Vasilopoulos, T, Svendsen, P, Moestrup, S K & Doré, S 2018, ' The absence of the CD163 receptor has distinct temporal influences on intracerebral hemorrhage outcomes ', Journal of Cerebral Blood Flow and Metabolism, vol. 38, no. 2, pp. 262-273 . https://doi.org/10.1177/0271678X17701459
Hemoglobin (Hb) toxicity precipitates secondary brain damage following intracerebral hemorrhage (ICH). CD163 is an anti-inflammatory Hb scavenger receptor and CD163-positive macrophages/microglia locally accumulate post-bleed, yet no studies have inv
Autor:
Alex Dang, Sylvain Doré, Pedro E. Cruz, Awilda M. Rosario, Jenna L Leclerc, Andrew S Lampert, Juan Santiago-Moreno, Todd E. Golde
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 38:1032-1046
Following intracerebral hemorrhage (ICH), extracellular heme precipitates secondary brain injury, which results in irreversible brain damage and enduring neurological deficits. Hemopexin (Hpx) is an endogenous protein responsible for scavenging heme,
Autor:
Alex Dang, Jenna L Leclerc, Andrew S Lampert, Tina Esfandiary, Juan Santiago-Moreno, Sylvain Doré, Harrison Phillips
Publikováno v:
Stroke. 50
Intracerebral hemorrhage (ICH) most commonly results from a hypertensive spontaneous bleed into the brain parenchyma and is a devastating stroke subtype. Hemolysis ensues and large quantities of hemoglobin (Hb) are released that initiate a toxic oxid
Autor:
Andrew S Lampert, Pia Svendsen, Terrie Vasilopolous, Brandon Schlackman, Søren K. Moestrup, Sylvain Doré, Claudia Loyola Amador, Jenna L Leclerc
Publikováno v:
Stroke. 48
Extracorpuscular hemoglobin (Hb)-induced toxicity following intracerebral hemorrhage (ICH) precipitates secondary brain damage and poor outcomes. CD163 is the Hb scavenger receptor with potent anti-inflammatory effects and CD163-positive macrophages/
Publikováno v:
Stroke. 47
With the population aging at an accelerated rate, the prevalence of stroke and financial burden of stroke-related health care costs is expected to continue to increase. Intracerebral hemorrhage (ICH) is a devastating stroke subtype more commonly affe
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 310(11)
With the population aging at an accelerated rate, the prevalence of stroke and financial burden of stroke-related health care costs are expected to continue to increase. Intracerebral hemorrhage (ICH) is a devastating stroke subtype more commonly aff
Publikováno v:
Stroke. 46
Inflammation after intracerebral hemorrhage (ICH) is a key component to secondary brain injury, a major cause of morbidity and disability after ICH. Prostaglandin E2 (PGE 2 ) plays an important role in modulating inflammatory responses and in many ne
Publikováno v:
The European journal of neuroscience. 41(10)
Intracerebral hemorrhage (ICH) is a stroke subtype associated with high mortality and morbidity. Following ICH, excitotoxicity and inflammation significantly contribute to secondary brain injury and poor outcomes. Prostaglandin E2 (PGE2 ) levels rise