Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Andrew S I, Loudon"'
Autor:
Helen E. Chmura, Cassandra Duncan, Ben Saer, Jeanette T. Moore, Brian M. Barnes, C. Loren Buck, Helen C. Christian, Andrew S. I. Loudon, Cory T. Williams
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Arctic ground squirrels hibernating in darkness activate the pars tuberalis - hypothalamus thyroid hormone signaling pathway, remodel hypothalamic tanycytes, and activate the reproductive axis.
Externí odkaz:
https://doaj.org/article/6832b2903caa4c0e9e095e8e29ccf0e8
Autor:
Alexander C. West, Yasutaka Mizoro, Shona H. Wood, Louise M. Ince, Marianne Iversen, Even H. Jørgensen, Torfinn Nome, Simen Rød Sandve, Samuel A. M. Martin, Andrew S. I. Loudon, David G. Hazlerigg
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Anadromous salmonids begin life adapted to the freshwater environments of their natal streams before a developmental transition, known as smoltification, transforms them into marine-adapted fish. In the wild, smoltification is a photoperiod-regulated
Externí odkaz:
https://doaj.org/article/62465038a9fc444396f2c0cc7cb01159
Autor:
Nan Yang, Nicola J Smyllie, Honor Morris, Cátia F Gonçalves, Michal Dudek, Dharshika R J Pathiranage, Johanna E Chesham, Antony Adamson, David G Spiller, Egor Zindy, James Bagnall, Neil Humphreys, Judith Hoyland, Andrew S I Loudon, Michael H Hastings, Qing-Jun Meng
Publikováno v:
PLoS Genetics, Vol 16, Iss 4, p e1008729 (2020)
Evolutionarily conserved circadian clocks generate 24-hour rhythms in physiology and behaviour that adapt organisms to their daily and seasonal environments. In mammals, the suprachiasmatic nucleus (SCN) of the hypothalamus is the principal co-ordina
Externí odkaz:
https://doaj.org/article/43fa25b09c644bd38b2e46c67b3637c5
Autor:
Alexander C. West, Laura Smith, David W. Ray, Andrew S. I. Loudon, Timothy M. Brown, David A. Bechtold
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
The misalignment between internal circadian rhythm and the day-night cycle can be caused by genetic, behavioural and environmental factors, and may have a profound impact on human physiology. Here West et al. show that desynchrony between the interna
Externí odkaz:
https://doaj.org/article/2d72018ac5b048df938b60e64d498dc6
Autor:
Helen E Chmura, Cassandra Duncan, Ben Saer, Jeanette T Moore, Brian M Barnes, C Loren Buck, Andrew S I Loudon, Cory T Williams
Publikováno v:
Integr Comp Biol
Many animals adjust the timing of seasonal events, such as reproduction, molt, migration, and hibernation, in response to interannual variation and directional climate-driven changes in temperature. However, the mechanisms by which temperature influe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7e07641384fb74f42d8413866603e22
https://doi.org/10.1093/icb/icac112
https://doi.org/10.1093/icb/icac112
Autor:
Polly Downton, Fabio Sanna, Robert Maidstone, Toryn M. Poolman, Edward A. Hayter, Suzanna H. Dickson, Nick A. Ciccone, James O. Early, Antony Adamson, David G. Spiller, Devin A. Simpkins, Matthew Baxter, Roman Fischer, Magnus Rattray, Andrew S. I. Loudon, Julie E. Gibbs, David A. Bechtold, David W. Ray
Publikováno v:
Downton, P, Sanna, F, Maidstone, R, Poolman, T, Hayter, E, Dickson, S, Early, J, Adamson, A, Spiller, D, Simpkins, D, Baxter, M, Fischer, R, Rattray, M, Loudon, A, Gibbs, J, Bechtold, D & Ray, D 2022, ' Chronic inflammatory arthritis drives systemic changes in circadian energy metabolism ', PNAS . https://doi.org/10.1073/pnas.2112781119
Chronic inflammation underpins many human diseases. Morbidity and mortality associated with chronic inflammation are often mediated through metabolic dysfunction. Inflammatory and metabolic processes vary through circadian time, suggesting an importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::017529c2364b29af243534f1e7291915
https://research.manchester.ac.uk/en/publications/800a87b1-8e94-4db1-bc84-0c5accdfbaf1
https://research.manchester.ac.uk/en/publications/800a87b1-8e94-4db1-bc84-0c5accdfbaf1
Autor:
John Blaikley, Andrew S. I. Loudon, Céline Vetter, Hannah J. Durrington, Frank A.J.L. Scheer, David W. Ray, Martin K. Rutter, Simon D. Kyle, Richa Saxena, Robert Maidstone, Hassan S. Dashti, James Turner, Debbie A Lawlor, Steven Shea
Publikováno v:
Thorax
IntroductionShift work causes misalignment between internal circadian time and the external light/dark cycle and is associated with metabolic disorders and cancer. Approximately 20% of the working population in industrialised countries work permanent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f370f065a30c6b7c2ae1a5bef0f7cf7
https://doi.org/10.1136/thoraxjnl-2020-215218
https://doi.org/10.1136/thoraxjnl-2020-215218
Autor:
Ayato Sato, Jiachen Shen, Andrew S. I. Loudon, Naoyuki Yamamoto, Akiko Shimada, Toshiya Nishimura, Toshitaka Nabeshima, Naoya Kadofusa, Kei Nakayama, Souta Minou, Minoru Tanaka, Nobuyuki Shiina, Tomoya Nakayama, Ai Shinomiya, Takashi Yoshimura, Ying-Jey Guh, Yuki Okushi, Taeko Nishiwaki-Ohkawa, Yusuke Nakane, Tsuyoshi Shimmura, T. Katherine Tamai, Yuko Furukawa, Kousuke Okimura
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance At high latitudes, about 10% of the population suffers from depression in winter. Although it has become a serious public health issue, its underlying mechanism remains unknown. Interestingly, animals also show depression-like behavior i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c65153757bd73a2dc4a52ef20d08ffba
https://doi.org/10.1073/pnas.2000278117
https://doi.org/10.1073/pnas.2000278117
Autor:
John Blaikley, Gareth B. Kitchen, Tracy Hussell, Mudassar Iqbal, Robert Maidstone, Laura Matthews, Hannah J. Durrington, Peter S. Cunningham, James Bagnall, Nicola Begley, Matthew Baxter, Ben Saer, Toryn Poolman, Julie E. Gibbs, Andrew S. I. Loudon, David W. Ray, David H. Dockrell
Publikováno v:
Kitchen, G B, Cunningham, P S, Poolman, T M, Iqbal, M, Maidstone, R, Baxter, M, Bagnall, J, Begley, N, Saer, B, Hussell, T, Matthews, L C, Dockrell, D H, Durrington, H J, Gibbs, J E, Blaikley, J F, Loudon, A S & Ray, D W 2020, ' The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia ', Proceedings of the National Academy of Sciences, vol. 117, no. 3, pp. 1543-1551 . https://doi.org/10.1073/pnas.1915932117
The circadian clock regulates many aspects of immunity. Bacterial infections are affected by time of day, but the mechanisms involved remain undefined. Here we show that loss of the core clock protein BMAL1 in macrophages confers protection against p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f2f3ec07d41a024bb148b8e2b4eb0d7
https://doi.org/10.1073/pnas.1915932117
https://doi.org/10.1073/pnas.1915932117
Autor:
Helen E. Chmura, Cassandra Duncan, Ben Saer, Jeanette T. Moore, Brian M. Barnes, C. Loren Buck, Helen C. Christian, Andrew S. I. Loudon, Cory T. Williams
Publikováno v:
Communications biology. 5(1)
Hibernation involves prolonged intervals of profound metabolic suppression periodically interrupted by brief arousals to euthermy, the function of which is unknown. Annual cycles in mammals are timed by a photoperiodically-regulated thyroid-hormone-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::235cc441559692987f91fa0fda8c45fb
https://pubmed.ncbi.nlm.nih.gov/35606540
https://pubmed.ncbi.nlm.nih.gov/35606540