Výsledky vyhledávání - "Andrew S Hirsh"

Akademický článek

Induction of stable drug resistance in human breast cancer cells using a combinatorial zinc finger transcription factor library.

Autor: Jeongeun Lee, Andrew S Hirsh, Ben S Wittner, Morgan L Maeder, Rajasekhar Singavarapu, Magdalena Lang, Sailajah Janarthanan, Ultan McDermott, Vijay Yajnik, Sridhar Ramaswamy, J Keith Joung, Dennis C Sgroi

Publikováno v: PLoS ONE, Vol 6, Iss 7, p e21112 (2011)

Combinatorial libraries of artificial zinc-finger transcription factors (ZF-TFs) provide a robust tool for inducing and understanding various functional components of the cancer phenotype. Herein, we utilized combinatorial ZF-TF library technology to

Externí odkaz: https://doaj.org/article/94aa3d71087b4f05a83d837f9ac128ed

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Standardized reagents and protocols for engineering zinc finger nucleases by modular assembly

Autor: J. Keith Joung, Magdalena Eichtinger, Daniel F. Voytas, Andrew S. Hirsh, David A. Wright, Drena Dobbs, Matthew H. Porteus, Jeffry D. Sander, Stacey Thibodeau-Beganny, Ronnie J. Winfrey, Fengli Fu

Publikováno v: Nature Protocols. 1:1637-1652

Engineered zinc finger nucleases can stimulate gene targeting at specific genomic loci in insect, plant and human cells. Although several platforms for constructing artificial zinc finger arrays using "modular assembly" have been described, standardi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbee5d4346716a195ab4ac88a36dbbcb
https://doi.org/10.1038/nprot.2006.259

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Engineered Cys2His2 zinc finger DNA-binding domains

Autor: Andrew S. Hirsh, J. Keith Joung

Publikováno v: Gene Therapy and Regulation. 2:191-206

Gene therapy reagents such as artificial transcription factors and site-specific endonucleases require "made-to-order" DNA-binding domains with high affinity and specificity for novel target sequences. Cys2His2 zinc finger proteins are the best under

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27d522554a265752bba156044294f867
https://doi.org/10.1163/1568558042457479

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Genetic strategy for analyzing specificity of dimer formation: Escherichia coli cyclic AMP receptor protein mutant altered in its dimerization specificity

Autor: J K Joung, Ann Hochschild, Andrew S. Hirsh, C Yu, E H Chung, G King

Publikováno v: Genes & Development. 9:2986-2996

Many transcriptional regulators function in homo- or heterodimeric combinations. The same protein can carry out distinct regulatory functions depending on the partner with which it associates. Here, we describe a mutant of the Escherichia coli cAMP r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::471ea07a12eda4a4309facea63d95c9a
https://doi.org/10.1101/gad.9.23.2986

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