Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Andrew S Giraud"'
Autor:
Louise M Judd, Treve R Menheniott, Hui Ling, Cameron B Jackson, Meegan Howlett, Anastasia Kalantzis, Waldemar Priebe, Andrew S Giraud
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e95993 (2014)
Signal Transducer and Activator of Transcription-3 (STAT3) is constitutively activated in many cancers where it promotes growth, inflammation, angiogenesis and inhibits apoptosis. We have shown that STAT3 is constitutively activated in human gastric
Externí odkaz:
https://doaj.org/article/76c9ab94703544b984388bd5f71fe4a5
Autor:
Kai Syin Lee, Anastasia Kalantzis, Cameron B Jackson, Louise O'Connor, Naoko Murata-Kamiya, Masanori Hatakeyama, Louise M Judd, Andrew S Giraud, Trevelyan R Menheniott
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30786 (2012)
BACKGROUND: Most of what is known about the Helicobacter pylori (H. pylori) cytotoxin, CagA, pertains to a much-vaunted role as a determinant of gastric inflammation and cancer. Little attention has been devoted to potential roles of CagA in the majo
Externí odkaz:
https://doaj.org/article/1cca8a52b61849dd9ab2467ee2f4897a
Autor:
Chau P. Tran, Michelle Scurr, Louise O’Connor, Jon N. Buzzelli, Garrett Z. Ng, Sharleen Chung Nien Chin, Lincon A. Stamp, Toshinari Minamoto, Andrew S. Giraud, Louise M. Judd, Philip Sutton, Trevelyan R. Menheniott
Publikováno v:
Oncotarget. 13:785-799
Interleukin-33 (IL-33) is an IL-1 family cytokine known to promote T-helper (Th) type 2 immune responses that are often deregulated in gastric cancer (GC). IL-33 is overexpressed in human gastric tumours suggesting a role in driving GC progression al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca6385c74001496010f6e5f430f42e9
https://doi.org/10.18632/oncotarget.28238
https://doi.org/10.18632/oncotarget.28238
Autor:
Sohinee Sarkar, Ghazal Alipour Talesh, Philip Sutton, Sharleen Chung Nien Chin, Alison N Graham, Andrew S. Giraud, Louise O'Connor, John A. Cidlowski, Trevelyan R. Menheniott, Chau P. Tran, Toshinari Minamoto, Michelle Scurr, Jonathan T. Busada
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 319:G175-G188
Gastrokines (GKNs) are anti-inflammatory proteins secreted by gastric epithelial (surface mucous and pit) cells, with their aberrant loss of expression causally linked to premalignant inflammation and gastric cancer (GC). Transcriptional mechanisms a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::825e02dd53fffcf0ad7ed61d4afcac88
https://doi.org/10.1152/ajpgi.00019.2020
https://doi.org/10.1152/ajpgi.00019.2020
Autor:
Jon N. Buzzelli, Heather V. Chalinor, Daniel I. Pavlic, Philip Sutton, Trevelyan R. Menheniott, Andrew S. Giraud, Louise M. Judd
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 1, Iss 2, Pp 203-221.e3 (2015)
Background & Aims: Interleukin (IL)33 is a recently described alarmin that is highly expressed in the gastric mucosa and potently activates Th2 immunity. It may play a pivotal role during Helicobacter pylori infection. Here, we delineate the role of
Externí odkaz:
https://doaj.org/article/fe5f543641b74220a8c56ac1013b6d5c
Autor:
Louise M. Judd, Sharleen Chung Nien Chin, Garrett Z. Ng, Jon N. Buzzelli, Philip Sutton, Hiroko Oshima, Michelle Scurr, Louise O'Connor, Angelique Catubig, Trevelyan R. Menheniott, Masanobu Oshima, Andrew S. Giraud
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 316:G251-G262
Expression of the cytokine IL-11 is elevated in human Helicobacter pylori infection and progressively increases with worsening gastric pathology. Additionally, IL-11 is required for tumor development in STAT3-dependent murine models of gastric cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40d73e9fbc0780d1250064861c93c653
https://doi.org/10.1152/ajpgi.00304.2018
https://doi.org/10.1152/ajpgi.00304.2018
Publikováno v:
British Journal of Pharmacology. 173:2016-2029
Background and Purpose We evaluated the extent to which individual versus combination treatments that specifically target airway epithelial damage [trefoil factor-2 (TFF2)], airway fibrosis [serelaxin (RLX)] or airway inflammation [dexamethasone (DEX
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44ffe7eb16e8ad883f0a1feef4d334d6
https://doi.org/10.1111/bph.13494
https://doi.org/10.1111/bph.13494
Autor:
O. Hamilton, Joerg Mattes, Katrina J. Allen, Ralf G. Heine, Michelle Scurr, Daniel I. Pavlic, Louise O'Connor, Louise M. Judd, Adam Collison, Trevelyan R. Menheniott, Andrew S. Giraud, Jon N. Buzzelli, Neil M O'Brien-Simpson, K. Al Gazali
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 310:G13-G25
We tested whether the T helper (Th) type 2 (Th2) cell agonist and allergenic ligand IL-33 was associated with eosinophilic esophagitis (EoE) development in a pediatric cohort and whether IL-33 protein could induce disease symptoms in mice. Biopsies f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6443f7400a22a5790f316f6ce3a96602
https://doi.org/10.1152/ajpgi.00290.2015
https://doi.org/10.1152/ajpgi.00290.2015
Publikováno v:
Cellular Microbiology. 17:1570-1582
STAT3 imparts a profound influence on both the epithelial and immune components of the gastric mucosa, and through regulation of key intracellular signal transduction events, is well placed to control inflammatory and oncogenic outcomes in the contex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8fd525eb61c68b7f07ebf6fb1a50c9e
https://doi.org/10.1111/cmi.12518
https://doi.org/10.1111/cmi.12518
Autor:
Wanda Setlik, Deborah L. Gumucio, Karan Nagar, James G. Fox, Meenakshi Rao, Jean Phillipe Pradere, Michael Churchill, Yagnesh Tailor, Simon Renders, Sureshkumar Muthupalani, Heon Goo Lee, Nicholas A. Manieri, Mark Glaire, Andrew S. Giraud, Siddhartha Mukherjee, Tracy C. Grikscheit, Stefanie Gross, Richard A. Friedman, Bernhard W. Renz, Francis Y. Lee, Maximilian Reichert, Anil K. Rustgi, Daniel L. Worthley, Yoku Hayakawa, Yiling Si, Aysu Uygur, Abhinav Nair, Jared Carpenter, Samuel Asfaha, Ashley N. Martinez, Xiaowei Chen, Hongshan Wang, Peter A. Sims, Ajay Prakash, Mazen A. Kheirbek, Gerard Karsenty, Jon Michael Caldwell, Katherine D. Walton, Robert F. Schwabe, Alka Kolhe, Trevor A. Graham, Michael D. Gershon, Jocelyn T. Compton, Saqib Nizami, H. Paco Kang, Matthew G. Schwartz, Guangchun Jin, Timothy C. Wang, Daniel E. Levin, C. Benedikt Westphalen, Thaddeus S. Stappenbeck
Publikováno v:
Cell, vol 160, iss 1-2
PMC
Paediatrics Publications
PMC
Paediatrics Publications
The stem cells that maintain and repair the postnatal skeleton remain undefined. One model suggests that perisinusoidal mesenchymal stem cells (MSCs) give rise to osteoblasts, chondrocytes, marrow stromal cells, and adipocytes, although the existence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a0584b21d4cc6a0c685bd69e8d2f5e0