Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Andrew S Bell"'
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 7, p e0009490 (2021)
Treatment and control of schistosomiasis depends on a single drug, praziquantel, but this is not ideal for several reasons including lack of potency against the juvenile stage of the parasite, dose size, and risk of resistance. We have optimised the
Externí odkaz:
https://doaj.org/article/7da0507681ce4b879d1f9d9c0948fc22
Autor:
Nuha R Mansour, Ross Paveley, J Mark F Gardner, Andrew S Bell, Tanya Parkinson, Quentin Bickle
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 4, p e0004659 (2016)
An estimated 600 million people are affected by the helminth disease schistosomiasis caused by parasites of the genus Schistosoma. There is currently only one drug recommended for treating schistosomiasis, praziquantel (PZQ), which is effective again
Externí odkaz:
https://doaj.org/article/d3931aef593f48d39c5e473c5df191f8
Autor:
Daniel Paape, Andrew S Bell, William P Heal, Jennie A Hutton, Robin J Leatherbarrow, Edward W Tate, Deborah F Smith
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 12, p e3363 (2014)
We have refined a medium-throughput assay to screen hit compounds for activity against N-myristoylation in intracellular amastigotes of Leishmania donovani. Using clinically-relevant stages of wild type parasites and an Alamar blue-based detection me
Externí odkaz:
https://doaj.org/article/23dc13e9657b4edc9868aeb862c574e2
Autor:
Daniel B. Rosoff, Andrew S. Bell, Josephin Wagner, Lucas A. Mavromatis, Ali Hamandi, Lauren Park, Jeesun Jung, Falk W. Lohoff
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 1, Pp 29-40 (2024)
Background & Aims: Observational studies have linked lipid-lowering drug targets pro-protein convertase subtilisin/kexin 9 (PCSK9) and HMG-CoA reductase (HMGCR) with adverse liver outcomes; however, liver disease incidence varies across diverse popul
Externí odkaz:
https://doaj.org/article/0796deca2c944246820bcca9f91393cf
Autor:
Silvie Huijben, Andrew S Bell, Derek G Sim, Danielle Tomasello, Nicole Mideo, Troy Day, Andrew F Read
Publikováno v:
PLoS Pathogens, Vol 9, Iss 9, p e1003578 (2013)
Drug resistant pathogens are one of the key public health challenges of the 21st century. There is a widespread belief that resistance is best managed by using drugs to rapidly eliminate target pathogens from patients so as to minimize the probabilit
Externí odkaz:
https://doaj.org/article/0adf4f17574f44b1b92dc7eb29d68381
Autor:
Victoria C Barclay, Derek Sim, Brian H K Chan, Lucas A Nell, Maia A Rabaa, Andrew S Bell, Robin F Anders, Andrew F Read
Publikováno v:
PLoS Biology, Vol 10, Iss 7, p e1001368 (2012)
Malaria vaccine developers are concerned that antigenic escape will erode vaccine efficacy. Evolutionary theorists have raised the possibility that some types of vaccine could also create conditions favoring the evolution of more virulent pathogens.
Externí odkaz:
https://doaj.org/article/226e263b1947497aa18f70475a6dfc8a
Autor:
Andrew S Bell, Silvie Huijben, Krijn P Paaijmans, Derek G Sim, Brian H K Chan, William A Nelson, Andrew F Read
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e37172 (2012)
The evolution of drug resistant Plasmodium parasites is a major challenge to effective malaria control. In theory, competitive interactions between sensitive parasites and resistant parasites within infections are a major determinant of the rate at w
Externí odkaz:
https://doaj.org/article/108fb64e4c4b4ccd980aadd54475c8b3
Autor:
Andrew S Bell, James E Mills, Gareth P Williams, James A Brannigan, Anthony J Wilkinson, Tanya Parkinson, Robin J Leatherbarrow, Edward W Tate, Anthony A Holder, Deborah F Smith
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 6, Iss 4, p e1625 (2012)
Inhibition of N-myristoyltransferase has been validated pre-clinically as a target for the treatment of fungal and trypanosome infections, using species-specific inhibitors. In order to identify inhibitors of protozoan NMTs, we chose to screen a dive
Externí odkaz:
https://doaj.org/article/f9cdeabdf89e4f4f804ccc4da454aa0f
Autor:
Lucas A. Mavromatis, Daniel B. Rosoff, Andrew S. Bell, Jeesun Jung, Josephin Wagner, Falk W. Lohoff
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Biological aging is accompanied by increasing morbidity, mortality, and healthcare costs; however, its molecular mechanisms are poorly understood. Here, we use multi-omic methods to integrate genomic, transcriptomic, and metabolomic data and
Externí odkaz:
https://doaj.org/article/938396e1680e48e5a253466593730144
Autor:
Daniel B. Rosoff, Andrew S. Bell, Jeesun Jung, Josephin Wagner, Lucas A. Mavromatis, Falk W. Lohoff
Publikováno v:
Journal of the American College of Cardiology. 80:653-662
Lipid-lowering therapy with statins and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition are effective strategies in reducing cardiovascular disease risk; however, concerns remain about potential long-term adverse neurocognitive effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc271624a5b99d2076132f38494a7fc6
https://doi.org/10.1016/j.jacc.2022.05.041
https://doi.org/10.1016/j.jacc.2022.05.041