Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Andrew S, Arvai"'
Autor:
Michael A. Longo, Sunetra Roy, Yue Chen, Karl-Heinz Tomaszowski, Andrew S. Arvai, Jordan T. Pepper, Rebecca A. Boisvert, Selvi Kunnimalaiyaan, Caezanne Keshvani, David Schild, Albino Bacolla, Gareth J. Williams, John A. Tainer, Katharina Schlacher
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract RAD51C is an enigmatic predisposition gene for breast, ovarian, and prostate cancer. Currently, missing structural and related functional understanding limits patient mutation interpretation to homology-directed repair (HDR) function analysi
Externí odkaz:
https://doaj.org/article/3d21ced31b7c4fa39d8b21ed94cd204f
Autor:
Susan E. Tsutakawa, Mark J. Thompson, Andrew S. Arvai, Alexander J. Neil, Steven J. Shaw, Sana I. Algasaier, Jane C. Kim, L. David Finger, Emma Jardine, Victoria J.B. Gotham, Altaf H. Sarker, Mai Z. Her, Fahad Rashid, Samir M. Hamdan, Sergei M. Mirkin, Jane A. Grasby, John A. Tainer
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Flap Endonuclease 1 is a DNA replication and repair enzyme indispensable for maintaining genomic stability. Here the authors provide mechanistic details on how FEN1 selects for 5′-flaps and promotes catalysis to avoid large-scale repeat expansion b
Externí odkaz:
https://doaj.org/article/7d8f8666ae664b27be8155fb17c1e260
Autor:
John A. Tainer, Darin E. Jones, Yan Yan, Davide Moiani, John J. Pink, Stanton L. Gerson, Daniel J. Laverty, Sarita Namjoshi, Dave S. Shin, Yuriy Fedorov, Zamal Ahmed, My T. Nguyen, Andrew S. Arvai, Zachary D. Nagel, Edward J. Selvik
Publikováno v:
Progress in biophysics and molecular biology
Human uracil DNA-glycosylase (UDG) is the prototypic and first identified DNA glycosylase with a vital role in removing deaminated cytosine and incorporated uracil and 5-fluorouracil (5-FU) from DNA. UDG depletion sensitizes cells to high APOBEC3B de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b56ffc793d58107fe40a464f176770b
https://doi.org/10.1016/j.pbiomolbio.2021.02.004
https://doi.org/10.1016/j.pbiomolbio.2021.02.004
Autor:
Alexandra C. Willcox, Jack D. Griffith, Shuai Jiang, Altaf H. Sarker, Priscilla K. Cooper, Albino Bacolla, Clifford Ng, Mai Zong Her, John A. Tainer, Daniel J. Rosenberg, Aye C. Thwin, Andrew S. Arvai, Miaw Sheue Tsai, Michal Hammel, Kelly S. Trego, Alan G. Raetz, Brian Shih, Susan E. Tsutakawa, David S. Shin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance DNA repair is essential to life and to avoidance of genome instability and cancer. Xeroderma pigmentosum group G (XPG) protein acts in multiple DNA repair pathways, both as an active enzyme and as a scaffold for coordinating with other r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d593687d33295b79020224b75f084ffa
https://doi.org/10.1073/pnas.1921311117
https://doi.org/10.1073/pnas.1921311117
Autor:
John A. Tainer, Davide Moiani, Ashley M. Deacon, Millie M. Georgiadis, Matthew A. J. Duncton, Andrew P. Yeh, Patricia Pellicena, Andrew S. Arvai, David M. Wilson, Debanu Das
Publikováno v:
Progress in biophysics and molecular biology
Cancer will directly affect the lives of over one-third of the population. The DNA Damage Response (DDR) is an intricate system involving damage recognition, cell cycle regulation, DNA repair, and ultimately cell fate determination, playing a central
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2907db155d8a91d57edcb2e66d86b79e
https://escholarship.org/uc/item/00q4j9tj
https://escholarship.org/uc/item/00q4j9tj
Autor:
C.A. Brosey, Davide Moiani, John A. Tainer, Daryl A. Ronato, Aleem Syed, Elena Petricci, Andrew S. Arvai, Jean-Yves Masson
Publikováno v:
Methods in Enzymology ISBN: 9780128139790
For inhibitor design, as in most research, the best system is question dependent. We suggest structurally defined allostery to design specific inhibitors that target regions beyond active sites. We choose systems allowing efficient quality structures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::265d998d0d50a8c2cbf9b84271322c8f
https://doi.org/10.1016/bs.mie.2017.11.030
https://doi.org/10.1016/bs.mie.2017.11.030
Autor:
Patrick Tripp, Sonja-Verena Albers, Andrew S. Arvai, John A. Tainer, Justin P. Ishida, Chi Lin Tsai, Paushali Chaudhury, Ankan Banerjee
Publikováno v:
Structure(London, England:1993)
Summary Archaea employ the archaellum, a type IV pilus-like nanomachine, for swimming motility. In the crenarchaeon Sulfolobus acidocaldarius, the archaellum consists of seven proteins: FlaB/X/G/F/H/I/J. FlaF is conserved and essential for archaellum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5efe27c4f202f13722c8d1cd5bff4ac6
Autor:
Steven J. Shaw, Alexander J. Neil, Fahad Rashid, Altaf H. Sarker, Mark J. Thompson, Jane A. Grasby, Mai Zong Her, Victoria J. B. Gotham, Susan E. Tsutakawa, Emma C. Jardine, Andrew S. Arvai, Samir M. Hamdan, John A. Tainer, Sergei M. Mirkin, L. David Finger, Sana I. Algasaier, Jane C. Kim
Publikováno v:
Tsutakawa, SE; Thompson, MJ; Arvai, AS; Neil, AJ; Shaw, SJ; Algasaier, SI; et al.(2017). Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability. Nature Communications, 8. doi: 10.1038/ncomms15855. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/5zc3s29h
Nature communications, vol 8, iss 1
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications
Nature communications, vol 8, iss 1
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications
DNA replication and repair enzyme Flap Endonuclease 1 (FEN1) is vital for genome integrity, and FEN1 mutations arise in multiple cancers. FEN1 precisely cleaves single-stranded (ss) 5′-flaps one nucleotide into duplex (ds) DNA. Yet, how FEN1 select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11333b994a0137c384e97a1b59040a0f
http://www.escholarship.org/uc/item/5zc3s29h
http://www.escholarship.org/uc/item/5zc3s29h
Autor:
Susan E. Tsutakawa, Mark J. Thompson, Andrew S. Arvai, Alexander J. Neil, Steven J. Shaw, Sana I. Algasaier, Jane C. Kim, L. David Finger, Emma Jardine, Victoria J. B. Gotham, Altaf H. Sarker, Mai Z. Her, Fahad Rashid, Samir M. Hamdan, Sergei M. Mirkin, Jane A. Grasby, John A. Tainer
Publikováno v:
Nature Communications
Nature Communications 8 Article number: 15855 (2017); Published: 27 June 2017; Updated: 7 August 2017 The financial support for this Article was not fully acknowledged. The Acknowledgements should have included the following: This research used resou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1c9453139bf2ff1ec811a9671bf41b8
https://escholarship.org/uc/item/447808sk
https://escholarship.org/uc/item/447808sk
Autor:
Anton Cheltsov, Lynda M. Groocock, Karolin Luger, Minghua Nie, Eros Lazzerini-Denchi, Michael N. Boddy, Robert P. Rambo, John Prudden, J. Jefferson P. Perry, John A. Tainer, Andrew S. Arvai, Tao Wang, Chiharu Hitomi, Davide Moiani
Publikováno v:
EMBO reports. 15:601-608
The post-translational modification of DNA repair and checkpoint proteins by ubiquitin and small ubiquitin-like modifier (SUMO) critically orchestrates the DNA damage response (DDR). The ubiquitin ligase RNF4 integrates signaling by SUMO and ubiquiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a27bdb4f20ff031c36d9198d1ce0a2f0
https://doi.org/10.1002/embr.201338369
https://doi.org/10.1002/embr.201338369