Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Andrew Rutman"'
Ciliated conical epithelial cell protrusions point towards a diagnosis of primary ciliary dyskinesia
Autor:
Chris O’Callaghan, Andrew Rutman, Gwyneth Williams, Neeta Kulkarni, Joseph Hayes, Robert A. Hirst
Publikováno v:
Respiratory Research, Vol 19, Iss 1, Pp 1-6 (2018)
Abstract Background Primary ciliary dyskinesia can result from a number of different ciliary defects that adversely affect ciliary function resulting markedly reduced or absent mucociliary clearance. Improvement in diagnostic testing is an area of cu
Externí odkaz:
https://doaj.org/article/11189fa90fec46e8a3d37f8dfb5ed988
Autor:
Robert A Hirst, Claire L Jackson, Janice L Coles, Gwyneth Williams, Andrew Rutman, Patricia M Goggin, Elizabeth C Adam, Anthony Page, Hazel J Evans, Peter M Lackie, Christopher O'Callaghan, Jane S Lucas
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89675 (2014)
The diagnosis of primary ciliary dyskinesia (PCD) requires the analysis of ciliary function and ultrastructure. Diagnosis can be complicated by secondary effects on cilia such as damage during sampling, local inflammation or recent infection. To diff
Externí odkaz:
https://doaj.org/article/f40fd44fc77f4bfc8bf5409717d71003
Autor:
Mina J Fadaee-Shohada, Robert A Hirst, Andrew Rutman, Ian S Roberts, Chris O'Callaghan, Peter W Andrew
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10450 (2010)
Ciliated ependymal cells line the cerebral ventricles and aqueducts separating the infected CSF from the brain parenchyma in meningitis.Investigation of the interaction of Listeria monocytogenes with cultured rat brain ependymal cells showed that cer
Externí odkaz:
https://doaj.org/article/b5d36d0ff1934b90a6a2f0c5aa471efa
Autor:
Loo Chian Min, Wan-Teck Lim, Qixian He, Christopher O'Callaghan, Biju Thomas, Oon Hoe Teoh, Therese Sophie Lapperre, Su Ying Low, Ong Thun How, Robert A. Hirst, Mariko Siyue Koh, John E. Connolly, John Carson Allen, Andrew Rutman, Lynette L. E. Oon
Publikováno v:
COPD : journal of chronic obstructive pulmonary disease
Impaired mucociliary clearance may increase COPD exacerbation risk. We aimed to compare bronchial ciliary function and epithelial ultrastructure of COPD patients to healthy controls and explore its relationship to exacerbator phenotypes (frequent [FE
Autor:
Hannah M. Mitchison, Evie Robson, Dale Moulding, Andrew Rutman, Sam M. Janes, Daniel Peckham, Claire Smith, Dani Do Hyang Lee, Satyanarayana Somavarapu, Stephen L. Hart, Colin R. Butler, Philip L. Beales, Ersilia Nigro, Robert E. Hynds, Daniela Cardinale, Elisabeth Forsythe, Mahmoud R. Fassad, Robin Ketteler, Alexander Agrotis, Christopher O'Callaghan, Robert A. Hirst
Publikováno v:
The European Respiratory Journal
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Background Development of therapeutic approaches for rare respiratory diseases is hampered by the lack of systems that allow medium-to-high-throughput screening of fully differentiated respiratory epithelium from affected patients. This is a particul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe7bdc80b9353d49a8bcebcfe1959983
http://hdl.handle.net/11591/467848
http://hdl.handle.net/11591/467848
Autor:
Mahmoud R. Fassad, Colin R. Butler, Satyanarayana Somavarapu, Sam M. Janes, Stephen L. Hart, Daniela Cardinale, Philip L. Beales, Dani Do Hyang Lee, Elisabeth Forsythe, Ersilia Nigro, Daniel Peckham, Hannah M. Mitchison, Andrew Rutman, Alexander Agrotis, Claire Smith, Christopher O'Callaghan, Robert E. Hynds, Robin Ketteler, Evie Robson, Dale Moulding, Robert A. Hirst
Development of therapeutic approaches for rare respiratory diseases is hampered by the lack of systems that allow medium-to-high-throughput screening of fully differentiated respiratory epithelium from affected patients. This is a particular problem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e48e63d1e5b9666a19b90d00ef0d315c
Ciliated conical epithelial cell protrusions point towards a diagnosis of primary ciliary dyskinesia
Autor:
Robert A. Hirst, Neeta Kulkarni, Joseph Hayes, Andrew Rutman, Christopher O'Callaghan, Gwyneth Williams
Publikováno v:
Respiratory Research, Vol 19, Iss 1, Pp 1-6 (2018)
Respiratory Research
Respiratory Research
Background Primary ciliary dyskinesia can result from a number of different ciliary defects that adversely affect ciliary function resulting markedly reduced or absent mucociliary clearance. Improvement in diagnostic testing is an area of current res
Autor:
Petrina Lau, Michelle Simon, Anna Hoerder-Suabedissen, Federico Tinarelli, Andrew Rutman, Patrick M. Nolan, Neil R. Horner, Matthew Sweeting, Johanna E. Chesham, Sara Johnson, Henrik Westerberg, Gareth Banks, Ashleigh G. Wilcox, Zoltán Molnár, Alun R. Barnard, Valter Tucci, Robert A. Hirst, Glenda Lassi, Lee B. Smith, Michael H. Hastings, Thomas N. Lawson
Publikováno v:
Molecular Psychiatry
Banks, G, Lassi, G, Hoerder-Suabedissen, A, Tinarelli, F, Simon, M M, Wilcox, A, Lau, P, Lawson, T N, Johnson, S, Rutman, A, Sweeting, M, Chesham, J E, Barnard, A R, Horner, N R, Westerberg, H, Smith, L B, Molnar, Z, Hastings, M H, Hirst, R A, Tucci, V & Nolan, P 2017, ' A missense mutation in Katnal1 underlies behavioural, neurological and ciliary anomalies ', Molecular Psychiatry . https://doi.org/10.1038/mp.2017.54
Banks, G, Lassi, G, Hoerder-Suabedissen, A, Tinarelli, F, Simon, M M, Wilcox, A, Lau, P, Lawson, T N, Johnson, S, Rutman, A, Sweeting, M, Chesham, J E, Barnard, A R, Horner, N R, Westerberg, H, Smith, L B, Molnar, Z, Hastings, M H, Hirst, R A, Tucci, V & Nolan, P 2017, ' A missense mutation in Katnal1 underlies behavioural, neurological and ciliary anomalies ', Molecular Psychiatry . https://doi.org/10.1038/mp.2017.54
Microtubule severing enzymes implement a diverse range of tissue-specific molecular functions throughout development and into adulthood. Although microtubule severing is fundamental to many dynamic neural processes, little is known regarding the role
Autor:
Jean-Claude Pache, Heymut Omran, Amelia Shoemark, Karen Mackenney, Finn P. Reinholt, Estelle Escudier, Zuzanna Bukowy-Bieryllo, Paul Griffin, Andreia Pinto, Margaret W. Leigh, Robert A. Hirst, Panyiotis Yiallouros, Mieke Boon, Maria Margherita De Santi, Christoph Brochhausen, Andrew Rutman, Richard G. Hegele, Alison Lupton, Patricia Goggin
Publikováno v:
Paediatric respiratory epidemiology.
Primary Ciliary Dyskinesia (PCD) is a heterogeneous genetic condition. European and North American diagnostic guidelines recommend transmission electron microscopy as one of a combination of tests to confirm a diagnosis. However, there is no definiti
Autor:
Mahmoud R. Fassad, Andreia Pitno, Heba Morsy, Luísa Pereira, Carolina Constant, Nader Fasseeh, James A. Thompson, Paul Aurora, Claire L. Jackson, Andrew Rutman, Nisreen Rumman, Walaa I. Shoman, Robert A. Hirst, Amelia Shoemark, Susana S. Lopes, Hannah M. Mitchison, Christopher M. Watson, Priti Kenia, C. Hogg, Eduardo Moya, Jane S. Lucas, Christopher O'Callaghan, Lucy Jenkins, Robert Wilson, Sarah Ollosson, Patricia Goggin, Siobhán B. Carr, Mellisa Dixon, Philip Chetcuti, Michael R. Loebinger, Jane Hayward, Woolf T. Walker, Deborah J. Morris-Rosendahl, Andrew V. Rogers, Thomas Cullup, Mitali P. Patel, Eddie M.K. Chung
Publikováno v:
Journal of medical genetics. 57(5)
BackgroundPrimary ciliary dyskinesia (PCD), a genetically heterogeneous condition enriched in some consanguineous populations, results from recessive mutations affecting cilia biogenesis and motility. Currently, diagnosis requires multiple expert tes