Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Andrew R. Whittington"'
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :21-25
A racemic synthesis of two diastereoisomeric α-benzyloxycarbonylamino substituted trans-fused bicyclic lactams (4 and 5), was achieved from cyclopentene oxide. These lactams are useful intermediates to investigate the possibility of using a trans-la
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2239-2242
A series of substituted 4-amino-4H-pyran-2-carboxylic acid 6-triazoles and oxadiazoles are described. The compounds are inhibitors of influenza virus sialidases which, in general, show a similar pattern of activity and selectivity to recently reporte
Autor:
Helen Taylor, R. C. Bethell, Alan J. Wonacott, Anne Cleasby, Andrew R. Whittington, Peter M. Colman, Tadeusz Skarzynski, Jose Varghese, Jan Scicinski, Steven L. Sollis, O.M. Singh, Peter C. Cherry, Paul W. Smith, Neil Taylor, Kevin N. Cobley, Peter D. Howes
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2931-2936
The structure-activity relationships of a series of 4-amino and guanidino-4H-pyran-2-carboxylic acid 6-carboxamides are described. These compounds represent a new class of inhibitor of influenza sialidases and are particularly active against influenz
Autor:
R. C. Bethell, Andrew R. Whittington
Publikováno v:
Expert Opinion on Therapeutic Patents. 5:793-803
The patent literature on anti-influenza therapies covering the period 1993 to the first half of 1995 is reviewed. The antiviral intervention strategies used to combat influenza A and B are summarised, detailing the current status in each area and new
Autor:
Gavin A.C. Chung, Paul W. Smith, Mike R. Wood, Ken Duncan, Albert Jaxa Chamiec, Peter D. Howes, Andrew R. Whittington, Kevin N. Cobley
Publikováno v:
The Journal of Antibiotics. 48:73-82
A series of cephalosporins containing a novel 7-[2-(Z)-(2-amino-thiazol-4- yl)-3-(dimethoxy-phosphoryl)-acryloylamino] group were prepared and their antibacterial activity measured against a range of pathogens. In general the compounds displayed a br
Autor:
Lai Justine Yeun Quai, Brian Cox, Martyn Banks, C. Harri.Stylli, Andrew R. Whittington, Philip R. Tiller, Paul W. Smith, John G. Houston
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:2821-2824
A library of potentially 1600amide/ester dimers was prepared by reacting 40 acid chlorides with 40 nucleophiles. The whole library was presented for biological screening in 80 sample mixtures, with each of the possible products appearing in a unique
Autor:
Kevin N. Cobley, M. R. Wood, Peter David Howes, P.W. Smith, Andrew R. Whittington, Gavin A.C. Chung, A. Jaxa Chamiec, Ken Duncan
Publikováno v:
ChemInform. 26
Autor:
Helen Taylor, Paul W. Smith, Anne Cleasby, Steven L. Sollis, Jan Scicinski, R. C. Bethell, Alan J. Wonacott, Peter D. Howes, Jose Varghese, Kevin N. Cobley, Tadeusz Skarzynski, Peter M. Colman, Andrew R. Whittington, Neil Taylor, O.M. Singh, Peter C. Cherry
Publikováno v:
ChemInform. 28
The structure-activity relationships of a series of 4-amino and guanidino-4H-pyran-2-carboxylic acid 6-carboxamides are described. These compounds represent a new class of inhibitor of influenza sialidases and are particularly active against influenz
Publikováno v:
ChemInform. 32
A racemic synthesis of two diastereoisomeric α-benzyloxycarbonylamino substituted trans-fused bicyclic lactams (4 and 5), was achieved from cyclopentene oxide. These lactams are useful intermediates to investigate the possibility of using a trans-la