Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Andrew R. Reynolds"'
Autor:
Anne Cuypers, Laure-Anne Teuwen, Victoria L. Bridgeman, Laura P.M.H. de Rooij, Guy Eelen, Mieke Dewerchin, Anna Rita Cantelmo, Joanna Kalucka, Ann Bouché, Stefan Vinckier, An Carton, Ann Manderveld, Peter B. Vermeulen, Andrew R. Reynolds, Peter Carmeliet
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101691- (2022)
Summary: Tumor vessel co-option, a process in which cancer cells “hijack” pre-existing blood vessels to grow and invade healthy tissue, is poorly understood but is a proposed resistance mechanism against anti-angiogenic therapy (AAT). Here, we de
Externí odkaz:
https://doaj.org/article/fa9f0ce6728e4a4c942cd2c0c95db006
Autor:
Miran Rada, Audrey Kapelanski-Lamoureux, Stephanie Petrillo, Sébastien Tabariès, Peter Siegel, Andrew R. Reynolds, Anthoula Lazaris, Peter Metrakos
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Miran Rada et al. identify a key role for RUNX1 in liver metastasis of colorectal cancer. They show that RUNX1 is necessary for driving blood vessel co-option from surrounding liver tissue and that regulation of this process relies on a signaling fee
Externí odkaz:
https://doaj.org/article/8b1df7b825274fc992efc28e02e7aa91
Autor:
Chris T. Williamson, Rowan Miller, Helen N. Pemberton, Samuel E. Jones, James Campbell, Asha Konde, Nicholas Badham, Rumana Rafiq, Rachel Brough, Aditi Gulati, Colm J. Ryan, Jeff Francis, Peter B. Vermulen, Andrew R. Reynolds, Philip M. Reaper, John R. Pollard, Alan Ashworth, Christopher J. Lord
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Mutations in the BAF SWI/SNF complex subunits are frequent in cancers but selective therapeutic approaches are not available yet. Here, the authors demonstrate that defects ofARID1Aand other subunits sensitizes cancer cells to the DNA checkpoint kina
Externí odkaz:
https://doaj.org/article/e641244f3cf24d9e87d1e6540b5b48bf
Autor:
Andrew R. Reynolds
Publikováno v:
Dose-Response, Vol 8 (2010)
Tumor angiogenesis, the growth of new blood vessels into tumors, facilitates tumor growth and thus represents an attractive therapeutic target. Numerous experimental angiogenesis inhibitors have been characterised and subsequently trialled in patient
Externí odkaz:
https://doaj.org/article/0e6d7f41aa5642e69754b18fd317eec6
Colorectal cancer liver metastatic (CRCLM) tumours present as two main histopathological growth patterns (HGPs) including desmoplastic HGP (DHGP) and replacement HGP (RHGP). The DHGP tumours obtain their blood supply by sprouting angiogenesis, wherea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24926abf381ea01dfe2f03c598110c8f
https://doi.org/10.1101/2023.05.29.542731
https://doi.org/10.1101/2023.05.29.542731
Autor:
Susan Galbraith, Barry Crean, Gyorgy Zorenyi, Caroline Germa, Gaia Schiavon, Amaya Gasco Hernandez, Benjamin G. Challis, Eden Harrison, James Hadfield, Tina Sarbajna, Zoltan Szucs, Marianne Ashford, Farzana Walcott, Alula R. Yohannes, Michele Moschetta, Andrew R. Reynolds
Despite some notable successes, there are still relatively few agents approved for cancer prevention. Here we review progress thus far in the development of medicines for cancer prevention, and we outline some key concepts that could further enable o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::497147f971b38aaa0976b8d04d58dd9d
https://doi.org/10.1158/2159-8290.c.6602824.v1
https://doi.org/10.1158/2159-8290.c.6602824.v1
Autor:
Susan Galbraith, Barry Crean, Gyorgy Zorenyi, Caroline Germa, Gaia Schiavon, Amaya Gasco Hernandez, Benjamin G. Challis, Eden Harrison, James Hadfield, Tina Sarbajna, Zoltan Szucs, Marianne Ashford, Farzana Walcott, Alula R. Yohannes, Michele Moschetta, Andrew R. Reynolds
Tables that provide additional information to support the main article
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0655685c8a1eeb07fa541d987352f87
https://doi.org/10.1158/2159-8290.22644241
https://doi.org/10.1158/2159-8290.22644241
Autor:
Andrew R. Reynolds, Naveen S. Vasudev, Martin Gore, James Larkin, Paul D. Nathan, Thomas Powles, Caroline J. Springer, Natasha Preece, Peter B. Vermeulen, Sophia Frentzas, Jonathan C. Welti, Mark R. Nathan, Shane Foo, Elaine Wan, Victoria L. Bridgeman
Supplementary Figure 1 Growth kinetics for all 786-0 xenografts included in the analysis from Figure 1; Supplementary Figure 2 Details of the in vitro angiogenesis assay; Supplementary Figure 3 Isolation of a sunitinib-refractory sub-line (786-0-R) f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a34cdaeccfc1b318be4dda0463f1aa30
https://doi.org/10.1158/1535-7163.22504000.v1
https://doi.org/10.1158/1535-7163.22504000.v1
Autor:
Andrew R. Reynolds, Naveen S. Vasudev, Martin Gore, James Larkin, Paul D. Nathan, Thomas Powles, Caroline J. Springer, Natasha Preece, Peter B. Vermeulen, Sophia Frentzas, Jonathan C. Welti, Mark R. Nathan, Shane Foo, Elaine Wan, Victoria L. Bridgeman
Sunitinib and pazopanib are antiangiogenic tyrosine kinase inhibitors (TKI) used to treat metastatic renal cell carcinoma (RCC). However, the ability of these drugs to extend progression-free and overall survival in this patient population is limited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d79ea775b636def7c095ac76ea888fd
https://doi.org/10.1158/1535-7163.c.6537586.v1
https://doi.org/10.1158/1535-7163.c.6537586.v1
Autor:
Nicholas C. Turner, Alan Ashworth, Jorge S. Reis-Filho, Andrew R. Reynolds, Rachael Natrajan, Jonathan C. Welti, Alan Mackay, Damian Johnson, Maria T. Herrera-Abreu, Alex Pearson, Rachel Sharpe
Purpose: The oncogenic drivers of triple-negative (TN) and basal-like breast cancers are largely unknown. Substantial evidence now links aberrant signaling by the fibroblast growth factor receptors (FGFR) to the development of multiple cancer types.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2afbebdb78f6c0b424af8b542faac90d
https://doi.org/10.1158/1078-0432.c.6519678
https://doi.org/10.1158/1078-0432.c.6519678