Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Andrew R. Patterson"'
Autor:
Andrew R. Patterson, Mehari Endale, Kristin Lampe, Halil I. Aksoylar, Aron Flagg, Jim R. Woodgett, David Hildeman, Michael B. Jordan, Harinder Singh, Zeynep Kucuk, Jack Bleesing, Kasper Hoebe
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Loss of function GIMAP5 mutation is associated with lymphopenia, but how it mediates T cell homeostasis is unclear. Here the authors study Gimap5−/− mice and a patient with GIMAP5 deficiency to show how this GTPAse negatively regulates GSK3β act
Externí odkaz:
https://doaj.org/article/09487aa202ff4465abb8756803164dd9
Autor:
Andrew R. Patterson, Gabriel A. Needle, Ayaka Sugiura, Channing Chi, KayLee K. Steiner, Emilie L. Fisher, Gabriella L. Robertson, Caroline Bodnya, Janet G. Markle, Vivian Gama, Jeffrey C. Rathmell
Publikováno v:
bioRxiv
SUMMARYInborn Errors of Metabolism (IEM) and Immunity (IEI) are Mendelian diseases in which complex phenotypes and patient rarity can limit clinical annotations. Few genes are assigned to both IEM and IEI, but immunometabolic demands suggest function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d03e22ef76f827ee75ea22de50a86e49
https://doi.org/10.1101/2023.01.24.525419
https://doi.org/10.1101/2023.01.24.525419
Autor:
Darren R. Heintzman, Joel Elasy, Channing Chi, Xiang Ye, Evan S. Krystoviak, Wasay Khan, Lana Olson, Angela Jones, Kelsey Voss, Andrew R. Patterson, Ayaka Sugiura, Frank M. Mason, Hanna S. Hong, Lindsay Bass, Katherine L. Beier, Wentao Deng, Costas A. Lyssiotis, Alexander G. Bick, W. Kimryn Rathmell, Jeffrey C. Rathmell
Heat is a cardinal feature of inflammation. Despite temperature variability and dependence of enzymes and complexes, how heat and fever affect immune cells remains uncertain. We found that heat broadly increased inflammatory activity of CD4+T cell su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58b80dffaeb56014c0a7e92eae5c7b0f
https://doi.org/10.1101/2022.11.14.516478
https://doi.org/10.1101/2022.11.14.516478
Autor:
Kasper Hoebe, Shrinivas Bishu, John Y. Kao, Varsha Ganesan, Ankit Sharma, Yanfen Yang, Chang Zeng, Rodney D. Newberry, Sahiti Marella, Simon P. Hogan, Philip D. King, Ariel Munitz, Jazib Uddin, Taeko K. Noah, Lee A. Denson, Andrew R. Patterson, Simone Vanoni, Lisa Waggoner, Senad Divanovic, Paul S. Foster, Michael J. Rosen, S. M. S. Tomar
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1479-1502 (2021)
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1479-1502 (2021)
Background & Aims CD4+ T cells are regulated by activating and inhibitory cues, and dysregulation of these proper regulatory inputs predisposes these cells to aberrant inflammation and exacerbation of disease. We investigated the role of the inhibito
Autor:
Bradley I. Reinfeld, Andrew R. Patterson, Rachel E. Brown, Allison S. Cohen, Matthew H. Wilson, Anna Chytil, M. Noor Tantawy, Vera M. Todd, W. David Merryman, Jeffrey C. Rathmell, H. Charles Manning, Matthew G. Vander Heiden, Jackie E. Bader, Matthew Z. Madden, Abin Abraham, Alexander Muir, Frank M. Mason, Ahmed Ali, Christopher S. Williams, Richard T. O’Neil, Brian T. Do, Ayaka Sugiura, Tessa Huffstater, Kirsten Young, Rachelle W. Johnson, Caroline A. Lewis, Melissa M. Wolf, Emily F. Mason, Katherine E. Beckermann, W. Kimryn Rathmell, Fuxue Xin, Rachel Hongo
Publikováno v:
Nature. 593:282-288
Cancer cells characteristically consume glucose through Warburg metabolism1, a process that forms the basis of tumour imaging by positron emission tomography (PET). Tumour-infiltrating immune cells also rely on glucose, and impaired immune cell metab
Autor:
Bradley I, Reinfeld, Matthew Z, Madden, Melissa M, Wolf, Anna, Chytil, Jackie E, Bader, Andrew R, Patterson, Ayaka, Sugiura, Allison S, Cohen, Ahmed, Ali, Brian T, Do, Alexander, Muir, Caroline A, Lewis, Rachel A, Hongo, Kirsten L, Young, Rachel E, Brown, Vera M, Todd, Tessa, Huffstater, Abin, Abraham, Richard T, O'Neil, Matthew H, Wilson, Fuxue, Xin, M Noor, Tantawy, W David, Merryman, Rachelle W, Johnson, Christopher S, Williams, Emily F, Mason, Frank M, Mason, Katherine E, Beckermann, Matthew G, Vander Heiden, H Charles, Manning, Jeffrey C, Rathmell, W Kimryn, Rathmell
Publikováno v:
Signal Transduction and Targeted Therapy
Cancer cells characteristically consume glucose through Warburg metabolism
Autor:
Andrew R, Patterson, Paige, Bolcas, Kristin, Lampe, Rachel, Cantrell, Brandy, Ruff, Ian, Lewkowich, Simon P, Hogan, Edith M, Janssen, Jack, Bleesing, Gurjit K, Khurana Hershey, Kasper, Hoebe
Publikováno v:
The Journal of allergy and clinical immunology. 143(1)
BACKGROUND: The GTPase of immunity-associated protein 5 is essential for lymphocyte homeostasis and survival. Recently, human GIMAP5 SNPs have been linked with an increased risk for asthma, while the loss of Gimap5 in mice has been associated with se
Autor:
Kasper Hoebe, David A. Hildeman, Michael B. Jordan, Aron Flagg, James R. Woodgett, Mehari Endale, Andrew R. Patterson, Jack J. Bleesing, Halil Ibrahim Aksoylar, Zeynep Yesim Kucuk, Kristin Lampe, Harinder Singh
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Nature Communications
Nature Communications
GTPase of immunity-associated protein 5 (Gimap5) is linked with lymphocyte survival, autoimmunity, and colitis, but its mechanisms of action are unclear. Here, we show that Gimap5 is essential for the inactivation of glycogen synthase kinase-3β (GSK
Autor:
Simon P. Hogan, Gurjit K. Khurana Hershey, Paige E. Bolcas, Jack J. Bleesing, Ian P. Lewkowich, Rachel Cantrell, Andrew R. Patterson, Kasper Hoebe, Edith M. Janssen, Brandy P. Ruff, Kristin Lampe
Publikováno v:
Journal of Allergy and Clinical Immunology. 143:245-257.e6
Background GTPase of immunity-associated protein 5 (GIMAP5) is essential for lymphocyte homeostasis and survival. Recently, human GIMAP5 single nucleotide polymorphisms have been linked to an increased risk for asthma, whereas loss of Gimap5 in mice
Publikováno v:
Inflammatory Bowel Diseases. 22:S49