Real-time measurement of tumour hypoxia using an implantable microfabricated oxygen sensor

Autor: Jamie R.K. Marland, Mark E. Gray, Camelia Dunare, Ewen O. Blair, Andreas Tsiamis, Paul Sullivan, Eva González-Fernández, Stephen N. Greenhalgh, Rachael Gregson, R. Eddie Clutton, Magdalena M. Parys, Alex Dyson, Mervyn Singer, Ian H. Kunkler, Mark A. Potter, Srinjoy Mitra, Jonathan G. Terry, Stewart Smith, Andrew R. Mount, Ian Underwood, Anthony J. Walton, David J. Argyle, Alan F. Murray

Publikováno v: Sensing and Bio-Sensing Research, Vol 30, Iss , Pp 100375- (2020)

Hypoxia commonly occurs within tumours and is a major cause of radiotherapy resistance. Clinical outcomes could be improved by locating and selectively increasing the dose delivered to hypoxic regions. Here we describe a miniature implantable sensor

Externí odkaz: https://doaj.org/article/4d575ed143ff4ab788ad2253711af3ac

A Microelectrode Array with Reproducible Performance Shows Loss of Consistency Following Functionalization with a Self-Assembled 6-Mercapto-1-hexanol Layer

Autor: Damion K. Corrigan, Vincent Vezza, Holger Schulze, Till T. Bachmann, Andrew R. Mount, Anthony J. Walton, Jonathan G. Terry

Publikováno v: Sensors, Vol 18, Iss 6, p 1891 (2018)

For analytical applications involving label-free biosensors and multiple measurements, i.e., across an electrode array, it is essential to develop complete sensor systems capable of functionalization and of producing highly consistent responses. To a

Externí odkaz: https://doaj.org/article/7b2e4d003ba041d2b9d9a2e8ff5ea894

Electrofabrication of a low molecular weight hydrogel at high pH

Autor: Courtenay Patterson, Santanu Panja, Wanli Liu, Andrew R. Mount, Adam Squires, Dave J. Adams

Publikováno v: Patterson, C, Panja, S, Liu, W, Mount, A R, Squires, A & Adams, D J 2023, ' Electrofabrication of a low molecular weight hydrogel at high pH ', Materials Chemistry Frontiers . https://doi.org/10.1039/d3qm00091e

Fmoc-3 is a low-molecular-weight gelator that self-assembles to form hydrogels at basic pH. Here, using Fmoc-3, we show the first electrodeposition at high pH of a low molecular weight gelator using an electrochemically generated pH gradient. We also

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a689eceddc72607e2de80507a06822e1
https://hdl.handle.net/20.500.11820/62153003-3eec-440e-a86d-c483cac54664

Electrofabrication of large volume di- and tripeptide hydrogels via hydroquinone oxidation

Autor: Courtenay Patterson, Bart Dietrich, Claire Wilson, Andrew R. Mount, Dave J. Adams

Publikováno v: Patterson, C, Dietrich, B, Wilson, C, Mount, A R & Adams, D J 2022, ' Electrofabrication of large volume di-and tripeptide hydrogels via hydroquinone oxidation ', Soft Matter, vol. 18, no. 5, pp. 1064-1070 . https://doi.org/10.1039/d1sm01626a

The fabrication of protected peptide-based hydrogels on electrode surfaces can be achieved by employing the electrochemical oxidation of hydroquinone to benzoquinone, liberating protons at the electrode-solution interface. The localised reduction in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dfca49d69d2f32a93198a84280c89f8
https://www.pure.ed.ac.uk/ws/files/284280210/20220701_Mount_d1sm01626a_VoR.pdf

In vivo application of an implantable tri-anchored methylene blue-based electrochemical pH sensor

Autor: Ahmet Ucar, Stewart Smith, Jamie R. K. Marland, Matteo Staderini, Ewen O. Blair, Paul Sullivan, R. E. Clutton, Eva González-Fernández, Mark Gray, Mark Bradley, Andreas Tsiamis, David J. Argyle, Jonathan G. Terry, Alan F. Murray, Stephen N. Greenhalgh, Camelia Dunare, Anthony J. Walton, Rachael Gregson, Andrew R. Mount

Publikováno v: González-fernández, E, Staderini, M, Marland, J R K, Gray, M E, Uçar, A, Dunare, C, Blair, E O, Sullivan, P, Tsiamis, A, Greenhalgh, S N, Gregson, R, Clutton, R E, Smith, S, Terry, J G, Argyle, D J, Walton, A J, Mount, A R, Bradley, M & Murray, A F 2021, ' In vivo application of an implantable tri-anchored methylene blue-based electrochemical pH sensor ', Biosensors and Bioelectronics, pp. 113728 . https://doi.org/10.1016/j.bios.2021.113728

The development of robust implantable sensors is important in the successful advancement of personalised medicine as they have the potential to provide in situ real-time data regarding the status of health and disease and the effectiveness of treatme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4721ccc36575ae47ef2e80bbacb0484e
https://hdl.handle.net/20.500.11820/d2ed2ab0-e2ce-4cca-81e9-e1f267bfb8f4