Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Andrew R. Marderstein"'
Autor:
Andrew R. Marderstein, Manik Uppal, Akanksha Verma, Bhavneet Bhinder, Zakieh Tayyebi, Jason Mezey, Andrew G. Clark, Olivier Elemento
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Immune infiltration provides critical information for health and disease, yet it is unclear what factors influence infiltration levels. Here, the authors analyze human tissue transcriptomes from the Genotype-Tissue Expression project to find infiltra
Externí odkaz:
https://doaj.org/article/bdf1df0cbfa4438ab46ff62705e1237e
Autor:
Scott Kulm, Rulla M. Tamimi, Olivier Elemento, Andrew G. Clark, Andrew R. Marderstein, Cheng Peng
An individual’s genetics can dramatically influence breast cancer (BC) risk. While clinical measures for prevention do exist, non-invasive personalized measures for reducing BC risk are limited. Commonly-used medications are a promising set of modi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10838b2fcf28d6b648f4e10f6a778a5a
https://doi.org/10.1101/2021.05.03.21256511
https://doi.org/10.1101/2021.05.03.21256511
Autor:
Andrew G. Clark, Olivier Elemento, Andrew R. Marderstein, Scott Kulm, Rulla M. Tamimi, Cheng Peng
Publikováno v:
Am J Hum Genet
An individual’s genetics can dramatically influence breast cancer (BC) risk. Although clinical measures for prevention do exist, non-invasive personalized measures for reducing BC risk are limited. Commonly used medications are a promising set of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fa4ddf95071b87654cf5aaccbc3719b
https://pubmed.ncbi.nlm.nih.gov/34363748
https://pubmed.ncbi.nlm.nih.gov/34363748
Publikováno v:
SSRN Electronic Journal.
Clinically-actionable risk models may be significantly improved by including genetic information via polygenic risk scores (PRSs). Several attempts to determine the degree of PRS improvement have reached inconclusive answers, likely due to their focu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2b425edc8ddcbac1a6a1a206ad64505
https://doi.org/10.2139/ssrn.3808292
https://doi.org/10.2139/ssrn.3808292
Autor:
Cristopher V. Van Hout, Andrew G. Clark, Olivier Elemento, Andrew R. Marderstein, Emily R. Davenport, Scott Kulm
Publikováno v:
Am J Hum Genet
Although thousands of loci have been associated with human phenotypes, the role of gene-environment (GxE) interactions in determining individual risk of human diseases remains unclear. This is partly because of the severe erosion of statistical power
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fa8bde70860fa94856acdff9691f228
https://europepmc.org/articles/PMC7820920/
https://europepmc.org/articles/PMC7820920/
Autor:
Yajas Shah, Akanksha Verma, Andrew R. Marderstein, Jessica White, Bhavneet Bhinder, J. Sebastian Garcia Medina, Olivier Elemento
Publikováno v:
Cell reports. 37(10)
Older age is a strong risk factor for several diseases, including cancer. The etiology and biology of age-associated differences among cancers are poorly understood. To address this knowledge gap, we aim to delineate differences in tumor molecular ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee950dfd1d9975d4dbf4157235bbc41
https://pubmed.ncbi.nlm.nih.gov/34879281
https://pubmed.ncbi.nlm.nih.gov/34879281
Autor:
Emily R. Davenport, Scott Kulm, Cristopher V. Van Hout, Olivier Elemento, Andrew G. Clark, Andrew R. Marderstein
While thousands of loci have been associated with human phenotypes, the role of gene-environment (GxE) interactions in determining individual risk of human diseases remains unclear. This is partly due to the severe erosion of statistical power result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4d816d5308c4d2646162b5e6383eb40
https://doi.org/10.1101/2020.07.28.225730
https://doi.org/10.1101/2020.07.28.225730
Autor:
Zakieh Tayyebi, Bhavneet Bhinder, Akanksha Verma, Olivier Elemento, Jason G. Mezey, Andrew G. Clark, Manik Uppal, Andrew R. Marderstein
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Despite infiltrating immune cells having an essential function in human disease and patients’ responses to treatments, mechanisms influencing variability in infiltration patterns remain unclear. Here, using bulk RNA-seq data from 46 tissues in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8e5bb82282a8a489f3fc74330010036
https://doi.org/10.1038/s41467-020-16097-9
https://doi.org/10.1038/s41467-020-16097-9
Autor:
Bhavneet Bhinder, Jason G. Mezey, Manik Uppal, Olivier Elemento, Andrew G. Clark, Andrew R. Marderstein, Akanksha Verma
Despite infiltrating immune cells playing an essential role in human disease and the patient response to treatment, the central mechanisms influencing variability in infiltration patterns are unclear. Using bulk RNA-seq data from 53 GTEx tissues, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b6d9f9f8e7a523c1c3e2cc85326128
https://doi.org/10.1101/614305
https://doi.org/10.1101/614305
Autor:
Stephan R. Targan, Alexendar R. Perez, Gretchen E. Diehl, David Q. Shih, Jorge Gandara, Gregory G. Putzel, Ellen Scherl, Svetlana Lima, David R. Withers, Monica Viladomiu, Viola Woo, Andrew R. Marderstein, Jim G. Castellanos, Randy S. Longman
Publikováno v:
Immunity. 49:1077-1089.e5
Summary Inflammatory bowel disease (IBD) results from a dysregulated interaction between the microbiota and a genetically susceptible host. Genetic studies have linked TNFSF15 polymorphisms and its protein TNF-like ligand 1A (TL1A) with IBD, but the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c3d05797b6d4a0bac15cd0b56015b1
https://doi.org/10.1016/j.immuni.2018.10.014
https://doi.org/10.1016/j.immuni.2018.10.014