Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Andrew R. Mack"'
Autor:
Andrea M. Hujer, Steven H. Marshall, Andrew R. Mack, Kristine M. Hujer, Yamuna Devi Bakthavatchalam, Kushal Umarkar, Snehal R. Palwe, Swapna Takalkar, Prashant R. Joshi, Rahul Shrivastava, Hariharan Periasamy, Sachin S. Bhagwat, Mahesh V. Patel, Balaji Veeraraghavan, Robert A. Bonomo
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTMulti-drug resistant (MDR) Pseudomonas aeruginosa harbor a complex array of β-lactamases and non-enzymatic resistance mechanisms. In this study, the activity of a β-lactam/β-lactam-enhancer, cefepime/zidebactam, and novel β-lactam/β-lact
Externí odkaz:
https://doaj.org/article/89cbc21d5db4415483462f4e8fa03ecc
Autor:
Laura J Rojas, Mohamad Yasmin, Jacquelynn Benjamino, Steven M Marshall, Kailynn J DeRonde, Nikhil P Krishnan, Federico Perez, Andrew A Colin, Monica Cardenas, Octavio Martinez, Armando Pérez-Cardona, Daniel D Rhoads, Michael R Jacobs, John J LiPuma, Michael W Konstan, Alejandro J Vila, Andrea Smania, Andrew R Mack, Jacob G Scott, Mark D Adams, Lilian M Abbo, Robert A Bonomo
Publikováno v:
PLoS ONE, Vol 17, Iss 3, p e0265129 (2022)
BackgroundPseudomonas aeruginosa is a persistent and difficult-to-treat pathogen in many patients, especially those with Cystic Fibrosis (CF). Herein, we describe a longitudinal analysis of a series of multidrug resistant (MDR) P. aeruginosa isolates
Externí odkaz:
https://doaj.org/article/b792cfbcd3cf4cadae6ebcb48376470a
Autor:
Ioannis Galdadas, Shen Qu, Ana Sofia F Oliveira, Edgar Olehnovics, Andrew R Mack, Maria F Mojica, Pratul K Agarwal, Catherine L Tooke, Francesco Luigi Gervasio, James Spencer, Robert A Bonomo, Adrian J Mulholland, Shozeb Haider
Publikováno v:
eLife, Vol 10 (2021)
Understanding allostery in enzymes and tools to identify it offer promising alternative strategies to inhibitor development. Through a combination of equilibrium and nonequilibrium molecular dynamics simulations, we identify allosteric effects and co
Externí odkaz:
https://doaj.org/article/7aac1beac51a40888c31f6d01e330204
Publikováno v:
Infectious Disease Clinics of North America. 34:773-819
Significant advances were made in antibiotic development during the past 5 years. Novel agents were added to the arsenal that target critical priority pathogens, including multidrug-resistant Pseudomonas aeruginosa and carbapenem-resistant Enterobact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0b6a2f0b4f506b3fe2ddd471fbfe90e
https://doi.org/10.1016/j.idc.2020.05.001
https://doi.org/10.1016/j.idc.2020.05.001
Autor:
Andrea M. Hujer, Christopher R. Bethel, Magdalena A. Taracila, Steven H. Marshall, Laura J. Rojas, Marisa L. Winkler, Ronald E. Painter, T. Nicholas Domitrovic, Richard R. Watkins, Ayman M. Abdelhamed, Roshan D’Souza, Andrew R. Mack, Richard C. White, Thomas Clarke, Derrick E. Fouts, Michael R. Jacobs, Katherine Young, Robert A. Bonomo
Publikováno v:
Antimicrob Agents Chemother
Multidrug-resistant (MDR) Pseudomonas aeruginosa infections are a major clinical challenge. Many isolates are carbapenem resistant, which severely limits treatment options; thus, novel therapeutic combinations, such as imipenem-relebactam (IMI/REL),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d09322205e34d8516b64cd52565690
https://pubmed.ncbi.nlm.nih.gov/35435707
https://pubmed.ncbi.nlm.nih.gov/35435707
Autor:
Laura J. Rojas, Mohamad Yasmin, Jacquelynn Benjamino, Steven M. Marshall, Kailynn J. DeRonde, Nikhil P. Krishnan, Federico Perez, Andrew A. Colin, Monica Cardenas, Octavio Martinez, Armando Pérez-Cardona, Daniel D. Rhoads, Michael R. Jacobs, John J. LiPuma, Michael W. Konstan, Alejandro J. Vila, Andrea Smania, Andrew R. Mack, Jacob G. Scott, Mark D. Adams, Lilian M. Abbo, Robert A. Bonomo
Publikováno v:
PloS one. 17(3)
Background Pseudomonas aeruginosa is a persistent and difficult-to-treat pathogen in many patients, especially those with Cystic Fibrosis (CF). Herein, we describe a longitudinal analysis of a series of multidrug resistant (MDR) P. aeruginosa isolate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c72f3cdd9fb0036606e4f8e6ca80f4
https://pubmed.ncbi.nlm.nih.gov/35358221
https://pubmed.ncbi.nlm.nih.gov/35358221
Autor:
Andrew R Mack, Christopher Bethel, Magdalena A Taracilla, Focco van den Akker, Brittany A Miller, Tsuyoshi Uehara, David A Six, Krisztina M Papp-Wallace, Robert A Bonomo
Publikováno v:
Open Forum Infectious Diseases
Background PDC is a class C β-lactamase in P. aeruginosa. PDC-88 is a variant characterized by a Thr-Pro amino acid deletion in the R2-loop (Δ289-290; Fig. 1). This deletion reduces susceptibility to cefepime (FEP), ceftazidime (CAZ), and ceftoloza
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffa6f5afadd1de4fcabd9fc1ca022820
http://europepmc.org/articles/PMC8644514
http://europepmc.org/articles/PMC8644514
Autor:
Andrew R Mack, Christopher Bethel, Steven Marshall, Robin Patel, David van Duin, Vance G Fowler, Daniel D Rhoads, Michael Jacobs, Focco van den Akker, David A Six, Greg Moeck, Krisztina M Papp-Wallace, Robert A Bonomo
Publikováno v:
Open Forum Infectious Diseases
Background Carbapenem resistance in Klebsiellae spp. arises through mutational and acquired mechanisms and is considered an “urgent threat” by the CDC. VNRX-5236 is a bicyclic boronate β-lactamase inhibitor (BLI) that combines oral bioavailabili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d53d26d452359232a769ec0054cb5b1e
http://europepmc.org/articles/PMC8644492
http://europepmc.org/articles/PMC8644492
Autor:
Vijay Kumar, Andrew R Mack, Magdalena A. Taracila, Robert A. Bonomo, Malcolm G. P. Page, Focco van den Akker
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::735689962979b239e692cfb3c2d36f05
https://doi.org/10.1096/fasebj.2021.35.s1.01715
https://doi.org/10.1096/fasebj.2021.35.s1.01715
Autor:
Ioannis Galdadas, Shen Qu, Ana Sofia F Oliveira, Edgar Olehnovics, Andrew R Mack, Maria F Mojica, Pratul K Agarwal, Catherine L Tooke, Francesco Luigi Gervasio, James Spencer, Robert A Bonomo, Adrian J Mulholland, Shozeb Haider
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::048becd10c9f4bfd1d13379b4557b5ff
https://doi.org/10.7554/elife.66567.sa2
https://doi.org/10.7554/elife.66567.sa2
