Výsledky vyhledávání - "Andrew R. Knaggs"

Biotransformation of alosetron: Mechanism of hydantoin formation

Autor: Derek R. Sutherland, Karl M. Cable, Philip J. Sidebottom, Andrew R. Knaggs, Guy N. Wells, Richard J. P. Cannell

Publikováno v: Tetrahedron Letters. 36:477-480

The formation of the hydantoin biotransformation product (3) of Alosetron (1) has been shown to proceed via migration of the tricyclic lactam moiety and occurs with complete retention of both hydrogens in the C-7′ methylene group.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ca49046c7595369d8de3fe550f402185
https://doi.org/10.1016/0040-4039(94)02291-i

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Biosynthetic studies on taxol

Autor: Paul E. Fleming, Kevin Walker, Andrew R. Knaggs, M. Haertel, Heinz G. Floss, Ursula Mocek, A. Lansing

Publikováno v: Pure and Applied Chemistry. 66:2045-2048

The biosynthesis of the plant antitumor agent, taxol, was studied by feeding radioactive or stable isotope-labeled precursors to cut stems or to inner bark tissue of Taxus brevifolia. The labeled taxol was purified to radiochemical purity and subject

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc4e5c7a27231d27b8d8fbb73f06613b
https://doi.org/10.1351/pac199466102045

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Biosynthesis of the modified peptide antibiotic nosiheptide in Streptomyces actuosus

Autor: Ursula Mocek, Heinz G. Floss, John M. Beale, Reiko Tsuchiya, Tom Nguyen, Andrew R. Knaggs

Publikováno v: Journal of the American Chemical Society. 115:7557-7568

The biosynthesis of the highly modified thiopeptide antibiotic, nosiheptide (1), was studied by feeding radioactive and stable-isotope-labeled precursors to cultures of the producing organism, Streptomyces actuosus. The stable isotope enrichments and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b3de5597ff643cee1cb2a2facb79186
https://doi.org/10.1021/ja00070a001

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ChemInform Abstract: The Biosynthesis of Xanthocillin-X Monomethyl Ether in Dichotomomyces cejpii. Experiments on the Origin of the Isocyanide Carbon Atoms

Autor: Karl M. Cable, Jonathan Mann, Andrew R. Knaggs, Richard B. Herbert

Publikováno v: ChemInform. 22

Precursor feeding experiments establish that the isocyanide groups in xanthocillin-X monomethyl ether (XME)1 do not originate from (i) compounds associated with C1-tetrahydrofolate metabolism; (ii) the ureido group of citrulline, carbamoyl phosphate,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d00480befada0781d395fa1ba8306f9e
https://doi.org/10.1002/chin.199125255

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ChemInform Abstract: Biosynthesis of the Antibiotic Obafluorin from p-Aminophenylalanine and Glycine (Glyoxylate)

Autor: Andrew R. Knaggs, Richard B. Herbert

Publikováno v: ChemInform. 23

Results of experiments using ‘resting’ cells of Pseudomonas fluorescens with [2-13C]-, [1-13C]- and [2-2H2]-glycine as precursors show that glyoxylic acid is specifically the source of C-1 and C-2 of the antibiotic obafluorin 1. The 13C labelling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc36fa3cd5dc5fe1d67125a0ee85b6e7
https://doi.org/10.1002/chin.199215307

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