A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition

Autor: William A. Weiss, Neil E. Torbett, Zachary A. Knight, Mark M. Moasser, Antonio Luna-Moran, Kevan M. Shokat, David Stokoe, Andrew R. Houk

Publikováno v: Biochemical Journal. 415:97-110

The PI3K (phosphoinositide 3-kinase) pathway regulates cell proliferation, survival and migration and is consequently of great interest for targeted cancer therapy. Using a panel of small-molecule PI3K isoform-selective inhibitors in a diverse set of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82fd83cd9ee3c5bb7d4cf22009d28c92
https://doi.org/10.1042/bj20080639

Cooperative Hydrogen Bonding Effects Are Key Determinants of Backbone Amide Proton Chemical Shifts in Proteins

Autor: Laura L. Parker, Jan H. Jensen, and Andrew R. Houk

Publikováno v: Journal of the American Chemical Society. 128:9863-9872

A computational methodology for backbone amide proton chemical shift (delta(H)) predictions based on ab initio quantum mechanical treatment of part of the protein is presented. The method is used to predict and interpret 13 delta(H) values in protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db0c30e90a2855be91acbc56b8affdea
https://doi.org/10.1021/ja0617901

The RNA silencing endonuclease Argonaute 2 mediates specific antiviral immunity in Drosophila melanogaster

Autor: Maria-Carla Saleh, Bassam Berry, Catherine K. Foo, Christophe Antoniewski, Raul Andino, Andrew R. Houk, Ronald P. van Rij

Publikováno v: Genes and Development
Genes and Development, 2006, 20 (21), pp.2985-2995. ⟨10.1101/gad.1482006⟩
Genes and Development, Cold Spring Harbor Laboratory Press, 2006, 20 (21), pp.2985-2995. ⟨10.1101/gad.1482006⟩

Most organisms have evolved defense mechanisms to protect themselves from viruses and other pathogens. Arthropods lack the protein-based adaptive immune response found in vertebrates. Here we show that the central catalytic component of the RNA-induc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5b319e31e68594375da5b26ebb18b08
https://hal-pasteur.archives-ouvertes.fr/pasteur-01954329/document

Compete Globally, Bud Locally

Autor: Arthur Millius, Andrew R. Houk, Orion D. Weiner

Publikováno v: Cell. (4):656-658

For budding yeast to ensure formation of only one bud, cells must polarize toward one, and only one, site. Polarity establishment involves the Rho family GTPase Cdc42, which concentrates at polarization sites via a positive feedback loop. To assess w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd5ad21c20e38ca7b1d07b2c46cfd209