Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Andrew R. Germain"'
Autor:
Andrew R. Germain, Piyush Gupta, José Carlos Rodríguez Pérez, Yuxiong Feng, Etienne J. Donckele, Partha P. Nag, Cristina Fernandez, Benito Munoz, Stuart L. Schreiber, Sivaraman Dandapani, Michelle Palmer, Leigh C. Carmody, Lynn VerPlank, Barbara J. Morgan, Eric S. Lander
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1834-1838
A high-throughput screen (HTS) was conducted against stably propagated cancer stem cell (CSC)-enriched populations using a library of 300,718 compounds from the National Institutes of Health (NIH) Molecular Libraries Small Molecule Repository (MLSMR)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd8bfb8ebf8087cdc4f1641890cdbf16
https://doi.org/10.1016/j.bmcl.2013.01.025
https://doi.org/10.1016/j.bmcl.2013.01.025
Autor:
Sivaraman Dandapani, Jen Q. Pan, Andrew R. Germain, Shannon Nguyen, Michel Weïwer, Deepika Walpita, Michelle Palmer, Joshua R. Sacher, Linda Ross, José Carlos Rodríguez Pérez, Michael C. Lewis, Partha P. Nag, Michelle Walk, David E. Olson, Debasis Patnaik, Anne-Laure Barbe, Jaime H. Cheah, Shailesh Metkar, Benito Munoz, Yan-Ling Zhang, Kimberly Stegmaier, Arthur J. Campbell, Stuart L. Schreiber, W. Frank An, Edward M. Scolnick, Florence F. Wagner, Joshua Ketterman, Stephen J. Haggarty, Edward B. Holson, Fanny Lazzaro, Xi Shi, David Fei, Doug Barker, Taner Kaya, Joshua A. Bishop, Jennifer P. Gale
Publikováno v:
ACS chemical biology. 11(7)
The mood stabilizer lithium, the first-line treatment for bipolar disorder, is hypothesized to exert its effects through direct inhibition of glycogen synthase kinase 3 (GSK3) and indirectly by increasing GSK3's inhibitory serine phosphorylation. GSK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d49ecba0de1d65469dc419289c336eca
https://pubmed.ncbi.nlm.nih.gov/27128528
https://pubmed.ncbi.nlm.nih.gov/27128528
Autor:
Michelle Palmer, Sivaraman Dandapani, Cristina Galan-Rodriguez, Leigh C. Carmody, Chris Dockendorff, Ana Rodriguez, Andrew R. Germain, Lawrence MacPherson, Stephen Johnston, Benito Munoz, Joshua A. Bittker, Stuart L. Schreiber
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:7197-7200
We report the outcome of a high-throughput small-molecule screen to identify novel, nontoxic, inhibitors of Trypansoma cruzi, as potential starting points for therapeutics to treat for both the acute and chronic stages of Chagas disease. Two compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::703bc96e5374ce40d59f73a02506b049
https://doi.org/10.1016/j.bmcl.2011.09.057
https://doi.org/10.1016/j.bmcl.2011.09.057
Autor:
Monty Krieger, Michelle Palmer, Sivaraman Dandapani, Melissa Bennion, Patrick W. Faloon, Thomas J.F. Nieland, Partha P. Nag, Andrew R. Germain, Willmen Youngsaye, Benito Munoz, Chris Dockendorff, Marsha Penman, Stuart L. Schreiber, José Carlos Rodríguez Pérez, Miao Yu
Publikováno v:
Elsevier
A new series of potent inhibitors of cellular lipid uptake from HDL particles mediated by scavenger receptor, class B, type I (SR-BI) was identified. The series was identified via a high-throughput screen of the National Institutes of Health Molecula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247e18d1c60026814a6ce3a49133bb9b
https://pubmed.ncbi.nlm.nih.gov/25958245
https://pubmed.ncbi.nlm.nih.gov/25958245
Publikováno v:
Angewandte Chemie. 116:1259-1263
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36dea25e93760bce8f7d6c49311be155
https://doi.org/10.1002/ange.200353037
https://doi.org/10.1002/ange.200353037
Autor:
Sivaraman Dandapani, Marcel Kaiser, Jeremy R. Duvall, Andrew R. Germain, Juan C. Engel, José Carlos Rodríguez Pérez, Stuart L. Schreiber, Sebastian T. Le Quement, Danielle Kellar, Benito Munoz, Giovanni Muncipinto, James H. McKerrow, Michael Foley, Jiri Gut, Jean-Charles Marie, Michelle Palmer, Leigh C. Carmody, Ivan T. Jewett, Jair L. Siqueira-Neto, Ana Rodriguez
A phenotypic high-throughput screen using ∼100,000 compounds prepared using Diversity-Oriented Synthesis yielded stereoisomeric compounds with nanomolar growth-inhibition activity against the parasite Trypanosoma cruzi, the etiological agent of Cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::566271c6a656525fb1715e6147271240
https://europepmc.org/articles/PMC4027639/
https://europepmc.org/articles/PMC4027639/
Phenotypic high-throughput screening elucidates target pathway in breast cancer stem cell-like cells
Autor:
Andrew R. Germain, Michelle Palmer, José Carlos Rodríguez Pérez, Leigh C. Carmody, Lynn VerPlank, Partha P. Nag, Benito Munoz
Publikováno v:
Journal of biomolecular screening. 17(9)
Cancer stem cells (CSCs) are resistant to standard cancer treatments and are likely responsible for cancer recurrence, but few therapies target this subpopulation. Due to the difficulty in propagating CSCs outside of the tumor environment, previous w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae7fdbb75dff197a10d4d2fa148adae9
https://pubmed.ncbi.nlm.nih.gov/22941295
https://pubmed.ncbi.nlm.nih.gov/22941295
Autor:
Erin Forbeck, Partha P. Nag, Benito Munoz, Sivaraman Dandapani, Lynn VerPlank, Cristina Fernandez, José Carlos Rodríguez Pérez, Barbara J. Morgan, Piyush Gupta, Amal Ting, Eric S. Lander, Andrew R. Germain, Yuxiong Feng, Michelle Palmer, Leigh C. Carmody, Timothy A. Lewis, Stuart L. Schreiber
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(10)
A high-throughput screen (HTS) with the National Institute of Health-Molecular Libraries Small Molecule Repository (NIH-MLSMR) compound collection identified a class of acyl hydrazones to be selectively lethal to breast cancer stem cell (CSC) enriche
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::851233347c8e0e488bcf5661699baef2
https://pubmed.ncbi.nlm.nih.gov/22503247
https://pubmed.ncbi.nlm.nih.gov/22503247
Autor:
Daniel M. Bruggemeyer, Jianglong Zhu, Andrew R. Germain, John A. Porco, Cedric Genet, Peter O'Brien
Enantioselective syntheses of the azaphilone natural products (+)-sclerotiorin and (+)-8-O-methylsclerotiorinamine that possess the natural R-configuration at the quaternary center are reported. The syntheses were accomplished using copper-mediated a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d1a6c0539141adfd60db8fac542b57f
https://europepmc.org/articles/PMC3086581/
https://europepmc.org/articles/PMC3086581/
Publikováno v:
Angewandte Chemie; 2/27/2004, Vol. 116 Issue 10, p1259-1263, 5p