Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Andrew R. Ferguson"'
Autor:
Victor H. Engelhard, Andrew R. Ferguson, Randal K. Gregg, Eric F. Tewalt, J. David Peske, Arun B. Dutta, Jianhao Zeng, Nithya Srivinisan, Ashley L. Wilson, Amber N. Woods
Although CD8+ T cells are critical for controlling tumors, how they are recruited and home to primary and metastatic lesions is incompletely understood. We characterized the homing receptor (HR) ligands on tumor vasculature to determine what drives t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0edc53b1657573a41e255b84f0d5afb
https://doi.org/10.1158/2326-6066.c.6548726.v1
https://doi.org/10.1158/2326-6066.c.6548726.v1
Autor:
Victor H. Engelhard, Andrew R. Ferguson, Randal K. Gregg, Eric F. Tewalt, J. David Peske, Arun B. Dutta, Jianhao Zeng, Nithya Srivinisan, Ashley L. Wilson, Amber N. Woods
S1: LLC-OVA or MC-38-OVA tumors were harvested on day 14 (SC) or day 11 (IP). LLC-OVA tumors were flash frozen and stained for MadCAM-1 expression. Representative and summary data interrogating 8-10 random fields from single sections of 3 tumors each
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::281d96743aff82c3ec8629a0e778f316
https://doi.org/10.1158/2326-6066.22538255.v1
https://doi.org/10.1158/2326-6066.22538255.v1
Autor:
Christine D. Palmer, Meghan G. Hart, Sonia Kounlavouth, Harshni Venkatraman, Lauren D. Kraemer, Martina Marrali, Calixto Dominguez, Fatema Z. Chowdhury, Jason R. Jaroslavsky, Lindsey Arcebuche, Lorenzo Hernandez, Bukola Adeoye, Severino Cuison, Amy R. Rappaport, Greg Boucher, Monica Lane, Melissa Rotunno, Kenneth Avocetien, Leiliane Sousa, Chris Puccia, Molly Likes, Rahul Vegesna, Rita Zhou, Alexis Mantilla, Matthew J. Davis, Ankur Dhanik, Melissa Johnson, Andrew R. Ferguson, Karin Jooss
Publikováno v:
Cancer Research. 83:2267-2267
Mutations in the KRAS gene are among the most common driver mutations in cancer. Targeting KRAS G12C mutations has shown some promise in clinical studies, though acquired resistance mutations pose a challenge for small molecule-based monotherapies. V
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93ad16672aa616f9fe27fb240af508cd
https://doi.org/10.1158/1538-7445.am2023-2267
https://doi.org/10.1158/1538-7445.am2023-2267
Autor:
Christine D. Palmer, Amy R. Rappaport, Matthew J. Davis, Meghan G. Hart, Ciaran D. Scallan, Sue-Jean Hong, Leonid Gitlin, Lauren D. Kraemer, Sonia Kounlavouth, Aaron Yang, Lindsey Smith, Desiree Schenk, Mojca Skoberne, Kiara Taquechel, Martina Marrali, Jason R. Jaroslavsky, Charmaine N. Nganje, Elizabeth Maloney, Rita Zhou, Daniel Navarro-Gomez, Adrienne C. Greene, Gijsbert Grotenbreg, Renee Greer, Wade Blair, Minh Duc Cao, Shawn Chan, Kyounghwa Bae, Alexander I. Spira, Sameek Roychowdhury, David P. Carbone, Brian S. Henick, Charles G. Drake, Benjamin J. Solomon, Daniel H. Ahn, Amit Mahipal, Steve B. Maron, Benny Johnson, Raphael Rousseau, Roman Yelensky, Chih-Yi Liao, Daniel V. T. Catenacci, Andrew Allen, Andrew R. Ferguson, Karin Jooss
Publikováno v:
Nature medicine. 28(8)
Checkpoint inhibitor (CPI) therapies provide limited benefit to patients with tumors of low immune reactivity. T cell-inducing vaccines hold promise to exert long-lasting disease control in combination with CPI therapy. Safety, tolerability and recom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b98fe066b3154800e3b88b1ce6062d
https://pubmed.ncbi.nlm.nih.gov/35970920
https://pubmed.ncbi.nlm.nih.gov/35970920
Autor:
J. Randolph Hecht, Ardaman Shergill, Mark Gregory Goldstein, Bruno Fang, May Thet Cho, Heinz-Josef Lenz, Lyudmyla Derby Berim, Paul Eliezer Oberstein, Rachael A Safyan, Vivek Sawhney, Heloisa P. Soares, David R. Spigel, Alexander I. Spira, Andrew R. Ferguson, Brian Chauder, Alexander Starodub
Publikováno v:
Journal of Clinical Oncology. 40:TPS3635-TPS3635
TPS3635 Background: Treatment options for most patients with metastatic colorectal cancer (mCRC) are largely limited to cytotoxic chemotherapy, with little advancement in the last decade. Encouragingly, a small subset of patients deficient in mismatc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0ff743a9d42e7eb5f7e1c0731bb39d2
https://doi.org/10.1200/jco.2022.40.16_suppl.tps3635
https://doi.org/10.1200/jco.2022.40.16_suppl.tps3635
Autor:
Randal K. Gregg, Eric F. Tewalt, Amber N. Woods, Jianhao Zeng, Victor H. Engelhard, Nithya Srivinisan, J. David Peske, Ashley Wilson, Arun B. Dutta, Andrew R. Ferguson
Publikováno v:
Cancer Immunology Research. 5:1062-1073
Although CD8+ T cells are critical for controlling tumors, how they are recruited and home to primary and metastatic lesions is incompletely understood. We characterized the homing receptor (HR) ligands on tumor vasculature to determine what drives t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee8388f4d41cfc4f83c3ee09c080d01
https://doi.org/10.1158/2326-6066.cir-17-0190
https://doi.org/10.1158/2326-6066.cir-17-0190
Publikováno v:
The Journal of Immunology. 181:1814-1824
Exogenous dendritic cells display restricted trafficking when injected in vivo and stimulate CD8 T cell responses that are localized to a small number of lymphoid compartments. By examining these responses in the presence and absence of FTY720, a dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24aa83e957a91f235012860d7d1819c4
https://doi.org/10.4049/jimmunol.181.3.1814
https://doi.org/10.4049/jimmunol.181.3.1814
Autor:
C. Colin Brinkman, Kristian M. Hargadon, Victor H. Engelhard, Lisa A. Nichols, Elizabeth D. Thompson, Timothy N. J. Bullock, Angela L. Zarling, Andrew R. Ferguson
Publikováno v:
Immunological Reviews. 222:28-42
The ability of CD8 T cells to recognize melanoma tumors has led to the development of immunotherapeutic approaches that use the antigens CD8 T cells recognize. However, clinical responses rates have been disappointing. Here we summarize our work to u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85747a1ef5fd1233f40b25ad03227110
https://doi.org/10.1111/j.1600-065x.2008.00620.x
https://doi.org/10.1111/j.1600-065x.2008.00620.x
Publikováno v:
International Immunology. 16:1411-1422
Secreted IgM and complement are important mediators in the optimal initiation of primary T-dependent humoral immune responses. Secreted IgM serves as a natural adjuvant by enhancing the immunogenicity of protein antigens, perhaps as a result of IgM's
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9503648a964aee11ce88abcc4d40b4f9
https://doi.org/10.1093/intimm/dxh142
https://doi.org/10.1093/intimm/dxh142
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 184(8)
Previous work from this laboratory showed that generation of memory CD8 T cells by different immunization routes correlates with control of tumors growing in distinct sites. We hypothesized that effector CD8 T cell expression of adhesion proteins and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::104be273769c5d8408dd26abfa9c46b5
https://pubmed.ncbi.nlm.nih.gov/20212096
https://pubmed.ncbi.nlm.nih.gov/20212096