Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Andrew R. Cuddihy"'
Autor:
Ross D. Hannan, Gretchen Poortinga, Carleen Cullinane, Nadine Hein, Simon J. Harrison, Kylee H Maclachlan, Andrew R. Cuddihy
Publikováno v:
Blood. 132:1945-1945
Background: Multiple myeloma (MM) requires combination drug therapies to delay acquired drug resistance and clinical relapse. We co-developed CX-5461, a highly-selective inhibitor of RNA polymerase I-mediated rDNA transcription(1), currently in phase
Autor:
Andrew R. Cuddihy, Catriona McLean, Ioanna Savvidou, Tiffany Khong, Andrew Spencer, Stephen Horrigan
Publikováno v:
Molecular cancer therapeutics. 16(9)
Currently available treatment options are unlikely to be curative for the majority of multiple myeloma patients, emphasizing a continuing role for the introduction of investigational agents that can overcome drug resistance. The canonical Wnt/β-cate
Autor:
A Dickinson, Andrew R. Cuddihy, Jason E. Cain, William Lee, Andrew Spencer, Jacqueline Johnson, J. C. St. John, Beena Kumar, Terrance Grant Johns, D N Watkins, K-Y Yeung
Publikováno v:
Cell Death Discovery
Although mitochondrial DNA has been implicated in diseases such as cancer, its role remains to be defined. Using three models of tumorigenesis, namely glioblastoma multiforme, multiple myeloma and osteosarcoma, we show that mitochondrial DNA plays de
Autor:
Andrew R. Cuddihy, Shundi Ge, Judy Zhu, Julie Jang, Ann Chidgey, Gavin Thurston, Richard Boyd, Gay M. Crooks
Publikováno v:
Monash University
Although the mechanisms of cross-talk that regulate the hematopoietic and epithelial compartments of the thymus are well established, the interactions of these compartments with the thymic endothelium have been largely ignored. Current understanding
Autor:
Andrew R. Cuddihy, Gay M. Crooks
Publikováno v:
Biology of Blood and Marrow Transplantation. 13:43-46
Key aspects of adult stem cell biology include not ust identifying multipotent cells, but also determining hese cells’ physical location within the organism itelf, the entity referred to as the stem cell “niche.” chofield first proposed the con
Publikováno v:
Molecular and Cellular Biology. 24:662-674
The detection of DNA damage activates DNA repair pathways and checkpoints to allow time for repair. Ultimately, these responses must be coordinated to ensure that cell cycle progression is halted until repair is completed. Several multiprotein comple
Publikováno v:
Oncogene. 22:3721-3733
2-Aminopurine (2-AP) is an adenine analog shown to cause cells to bypass chemical- and radiation-induced cell cycle arrest through as-yet unidentified mechanisms. 2-AP has also been shown to act as a kinase inhibitor. Tumor suppressor p53 plays an im
Autor:
Ross A. Dickins, Matthew J. O'Connell, Merci Del Rosario, Andrew R. Cuddihy, Ian J. Frew, Christoph Reinhard, David D.L. Bowtell
Publikováno v:
Molecular and Cellular Biology. 22:8155-8164
p53 acts as a tumor suppressor by inducing cell cycle arrest, apoptosis, and senescence in response to cellular stresses such as DNA damage or oncogene activation. These effects are mediated largely through the function of p53 as a transcriptional ac
Publikováno v:
International Journal of Molecular Sciences
Non-melanomatous skin cancers (NMSCs), which include basal and squamous cell carcinoma (BCC and SCC respectively), represent a significant burden on the population as well as an economic load to the health care system, yet treatments of these prevent
Autor:
Elaine Sanij, Ross D. Hannan, Denis Drygin, Richard B. Pearson, Katherine M. Hannan, Simon J. Harrison, Andrew R. Cuddihy, Jirawas Sornkom, Carleen Cullinane, Mustapha Haddach, Kylee H Maclachlan, Grant A. McArthur, Luc Furic, Gretchen Poortinga, Nadine Hein
Publikováno v:
Cancer Research. 77:IA10-IA10
Recent findings by our group have been instrumental in the development of the novel selective inhibitors of RNA Polymerase I (Pol I) (Drygin et al., Cancer Research, 2011; Bywater et al. Cancer Cell, 2012). This work has led to the fundamental discov