Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Andrew R. Clark"'
Autor:
Andrew R. Clark, Jonathan Kulwatno, Sergey S. Kanovka, George J. Klarmann, Claudia E. Hernandez, Roman M. Natoli, Todd O. McKinley, Benjamin K. Potter, Christopher L. Dearth, Stephen M. Goldman
Publikováno v:
Journal of Functional Biomaterials, Vol 15, Iss 6, p 160 (2024)
Treatment of volumetric muscle loss (VML) faces challenges due to its unique pathobiology and lower priority in severe musculoskeletal injury management. Consequently, a need exists for multi-stage VML treatment strategies to accommodate delayed inte
Externí odkaz:
https://doaj.org/article/72c7a12d112b46799a7488f857faec97
Autor:
John D. O’Neil, Oliwia O. Bolimowska, Sally A. Clayton, Tina Tang, Kalbinder K. Daley, Samuel Lara-Reyna, Jordan Warner, Claire S. Martin, Rahul Y. Mahida, Rowan S. Hardy, J. Simon C. Arthur, Andrew R. Clark
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Glucocorticoids potently inhibit expression of many inflammatory mediators, and have been widely used to treat both acute and chronic inflammatory diseases for more than seventy years. However, they can have several unwanted effects, amongst which im
Externí odkaz:
https://doaj.org/article/0c68332b67164a39b8ddb3c585272fea
Autor:
Connor P. Dolan, Andrew R. Clark, Jessica M. Motherwell, Naveena B. Janakiram, Michael S. Valerio, Christopher L. Dearth, Stephen M. Goldman
Publikováno v:
npj Regenerative Medicine, Vol 7, Iss 1, Pp 1-10 (2022)
Abstract Volumetric muscle loss (VML)—defined as the irrecoverable loss of skeletal muscle tissue with associated persistent functional deficits—is among the most common and highly debilitating combat-related extremity injuries. This is particula
Externí odkaz:
https://doaj.org/article/72d56c9fcf8c4affa8c56f65a116b70e
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2023)
Musculoskeletal injuries (MSKIs) are a great hindrance to the readiness of the United States Armed Forces through lost duty time and reduced operational capabilities. While most musculoskeletal injuries result in return-to-duty/activity with no (func
Externí odkaz:
https://doaj.org/article/b0bfd1ab8098481389ce266f42fb127d
Autor:
Jane Falconer, Valentina Pucino, Sally A. Clayton, Jennifer L. Marshall, Sabrina Raizada, Holly Adams, Andrew Philp, Andrew R. Clark, Andrew Filer, Karim Raza, Stephen P. Young, Christopher D. Buckley
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Fibroblast-like synoviocytes (FLS) play an important role in maintaining joint homeostasis and orchestrating local inflammatory processes. When activated during injury or inflammation, FLS undergo transiently increased bioenergetic and biosynthetic d
Externí odkaz:
https://doaj.org/article/ce6682581bba4f588caf45fd21bf47b7
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Mitochondria are major energy-producing organelles that have central roles in cellular metabolism. They also act as important signalling hubs, and their dynamic regulation in response to stress signals helps to dictate the stress response of the cell
Externí odkaz:
https://doaj.org/article/06d31fbb12174bf5b9dc2368a2862a59
Autor:
Tina Tang, Thomas E. Scambler, Tim Smallie, Helen E. Cunliffe, Ewan A. Ross, Dalya R. Rosner, John D. O’Neil, Andrew R. Clark
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract In many different cell types, pro-inflammatory agonists induce the expression of cyclooxygenase 2 (COX-2), an enzyme that catalyzes rate-limiting steps in the conversion of arachidonic acid to a variety of lipid signaling molecules, includin
Externí odkaz:
https://doaj.org/article/e7a8d022846a45f791a2ff0161e3b82b
Autor:
Jayne E. Hastedt, Per Bäckman, Andrew R. Clark, William Doub, Anthony Hickey, Guenther Hochhaus, Phil J. Kuehl, Claus-Michael Lehr, Peter Mauser, Jason McConville, Ralph Niven, Masahiro Sakagimi, Jeffry G. Weers
Publikováno v:
AAPS Open, Vol 2, Iss 1, Pp 1-20 (2016)
Abstract The Biopharmaceutics Classification System (BCS), developed in the 1990s for oral immediate release drugs, is utilized by R&D scientists and regulators to streamline product development and regulatory approval timelines. This elegant, scienc
Externí odkaz:
https://doaj.org/article/dc4a2a80e1784e56a752697b1c07da75
Autor:
Alexander V. Misharin, Carla M. Cuda, Rana Saber, Jason D. Turner, Angelica K. Gierut, G. Kenneth Haines III, Sergejs Berdnikovs, Andrew Filer, Andrew R. Clark, Christopher D. Buckley, Gökhan M. Mutlu, G.R. Scott Budinger, Harris Perlman
Publikováno v:
Cell Reports, Vol 9, Iss 2, Pp 591-604 (2014)
Different subsets and/or polarized phenotypes of monocytes and macrophages may play distinct roles during the development and resolution of inflammation. Here, we demonstrate in a murine model of rheumatoid arthritis that nonclassical Ly6C− monocyt
Externí odkaz:
https://doaj.org/article/5f76a3ed4772478ea981cc4cf21d01b1
Autor:
Jayne E. Hastedt, Per Bäckman, Andrew R. Clark, William Doub, Anthony Hickey, Guenther Hochhaus, Phil J. Kuehl, Claus-Michael Lehr, Peter Mauser, Jason McConville, Ralph Niven, Masahiro Sakagami, Jeffry G. Weers
Publikováno v:
AAPS Open, Vol 2, Iss 1, Pp 1-1 (2016)
Externí odkaz:
https://doaj.org/article/6e5951894e0a4f65983b1feb9e14ab9c