Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Andrew R Tee"'
Autor:
Bernadette Carroll, Dorothea Maetzel, Oliver DK Maddocks, Gisela Otten, Matthew Ratcliff, Graham R Smith, Elaine A Dunlop, João F Passos, Owen Richard Davies, Rudolf Jaenisch, Andrew R Tee, Sovan Sarkar, Viktor I Korolchuk
Publikováno v:
eLife, Vol 9 (2020)
Externí odkaz:
https://doaj.org/article/6b2cf351d8cb4f19aed05575781ae9dc
Autor:
Bernadette Carroll, Dorothea Maetzel, Oliver DK Maddocks, Gisela Otten, Matthew Ratcliff, Graham R Smith, Elaine A Dunlop, João F Passos, Owen R Davies, Rudolf Jaenisch, Andrew R Tee, Sovan Sarkar, Viktor I Korolchuk
Publikováno v:
eLife, Vol 5 (2016)
The mammalian target of rapamycin complex 1 (mTORC1) is the key signaling hub that regulates cellular protein homeostasis, growth, and proliferation in health and disease. As a prerequisite for activation of mTORC1 by hormones and mitogens, there fir
Externí odkaz:
https://doaj.org/article/6984fb5071a4478b8cce115a8801a2ad
Autor:
Muireann Ní Bhaoighill, Juan M. Falcón‐Pérez, Félix Royo, Andrew R. Tee, Jason P. Webber, Elaine A. Dunlop
Publikováno v:
Journal of Extracellular Vesicles, Vol 12, Iss 6, Pp n/a-n/a (2023)
Abstract Hyperactivation of mechanistic target of rapamycin complex 1 (mTORC1) is a feature of many solid tumours and is a key pathogenic driver in the inherited condition Tuberous Sclerosis Complex (TSC). Modulation of the tumour microenvironment by
Externí odkaz:
https://doaj.org/article/8c6f1cb68aad4a4b801ac9725eaa29a1
Autor:
Elin Vinsland, Pranetha Baskaran, Simeon R. Mihaylov, Carl Hobbs, Hannah Wood, Ihssane Bouybayoune, Kriti Shah, Corinne Houart, Andrew R. Tee, Jernej Murn, Cathy Fernandes, Joseph M. Bateman
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Correct orchestration of nervous system development is a profound challenge that involves coordination of complex molecular and cellular processes. Mechanistic target of rapamycin (mTOR) signaling is a key regulator of nervous system develop
Externí odkaz:
https://doaj.org/article/d680b34dc4ab4a0a8a0923b28ff97310
Autor:
Yan Tong, Silpa Gampala, Ellie Rad, Ren Yuan Bai, Olivia Babb, Emily Hulsey, Fenil Shah, Chi Zhang, Steven D. Rhodes, Verena Staedtke, Randall Wireman, Brian L. Calver, Mark R. Kelley, Michelle Grimard, M. Reza Saadatzadeh, Abbi Smith, D. Wade Clapp, Andrew R. Tee, Karen E. Pollok, Melissa L. Fishel
Publikováno v:
British Journal of Cancer
Background MPNST is a rare soft-tissue sarcoma that can arise from patients with NF1. Existing chemotherapeutic and targeted agents have been unsuccessful in MPNST treatment, and recent findings implicate STAT3 and HIF1-α in driving MPNST. The DNA-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec69838060868f6ccae17ccdf078f1f2
http://europepmc.org/articles/PMC8076291
http://europepmc.org/articles/PMC8076291
Autor:
Pranetha Baskaran, Simeon R. Mihaylov, Elin Vinsland, Kriti Shah, Lucy Granat, Sila K. Ultanir, Andrew R. Tee, Jernej Murn, Joseph M. Bateman
Mechanistic target of rapamycin (mTOR) is a protein kinase that integrates multiple inputs to regulate anabolic cellular processes. For example , mTOR complex I (mTORC1) has key functions in growth control, autophagy and metabolism. However, much les
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56a295d25117790d96fd0b7bde71d2fc
https://doi.org/10.1101/2022.04.08.487575
https://doi.org/10.1101/2022.04.08.487575
Autor:
Silpa Gampala, Fenil Shah, Chi Zhang, Steven D. Rhodes, Olivia Babb, Michelle Grimard, Randall S. Wireman, Ellie Rad, Brian Calver, Ren-Yuan Bai, Verena Staedtke, Emily L. Hulsey, M. Reza Saadatzadeh, Karen E. Pollok, Yan Tong, Abbi E. Smith, D. Wade Clapp, Andrew R. Tee, Mark R. Kelley, Melissa L. Fishel
Publikováno v:
British Journal of Cancer. 127:1378-1379
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb45084bca0069024d9649d0bed35cd5
https://doi.org/10.1038/s41416-022-01938-9
https://doi.org/10.1038/s41416-022-01938-9
Autor:
Andrew R. Tee, Pavandeep K. Rai, Douglass M. Turnbull, Mohd Shazli Draman, Colin M. Dayan, Lei Zhang, Marian Ludgate, D. Aled Rees, Satomi Miwa, Daniel S Morris, Anjana S Haridas
Context Depot-specific expansion of orbital adipose tissue (OAT) in Graves orbitopathy (GO; an autoimmune condition producing proptosis, visual impairment and reduced quality of life) is associated with fatty acid (FA)-uptake–driven adipogenesis in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90d17d1ca9f92e5bf145d5296d378ec8
Autor:
Jesse D. Champion, Kayleigh M. Dodd, Hilaire C. Lam, Mohammad A. M. Alzahrani, Sara Seifan, Ellie Rad, David Oliver Scourfield, Melissa L. Fishel, Brian L. Calver, Ann Ager, Elizabeth P. Henske, David Mark Davies, Mark R. Kelley, Andrew R. Tee
Publikováno v:
Cancers; Volume 14; Issue 24; Pages: 6195
Therapies with the mechanistic target of rapamycin complex 1 (mTORC1) inhibitors are not fully curative for tuberous sclerosis complex (TSC) patients. Here, we propose that some mTORC1-independent disease facets of TSC involve signaling through redox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38a649a247cc5a0102d117b241c81851
https://doi.org/10.3390/cancers14246195
https://doi.org/10.3390/cancers14246195
Autor:
João F. Passos, Dorothea Maetzel, Elaine A. Dunlop, Oliver D. K. Maddocks, Sovan Sarkar, Gisela Otten, Andrew R. Tee, Graham Smith, Viktor I. Korolchuk, Owen R. Davies, Bernadette Carroll, Rudolf Jaenisch, Matthew Ratcliff
Publikováno v:
eLife, Vol 9 (2020)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1626c38e54bd05c1f9c57a446133aeae
https://elifesciences.org/articles/65744
https://elifesciences.org/articles/65744