Zobrazeno 1 - 10
of 282
pro vyhledávání: '"Andrew R Marks"'
Autor:
Min Su, Feng Gao, Qi Yuan, Yang Mao, De-lin Li, Youzhong Guo, Cheng Yang, Xiao-hui Wang, Renato Bruni, Brian Kloss, Hong Zhao, Yang Zeng, Fa-ben Zhang, Andrew R Marks, Wayne A Hendrickson, Yu-hang Chen
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Trimeric intracellular cation channels (TRICs) elicit K+ currents to counteract luminal negative potential during Ca2+release from intracellular stores. Here the authors present structures of prokaryotic TRICs in their open and closed states, obtaini
Externí odkaz:
https://doaj.org/article/2a4a9abd619e4a199b9d5f94dba0f20f
Autor:
Marco C. Miotto, Steven Reiken, Anetta Wronska, Qi Yuan, Haikel Dridi, Yang Liu, Gunnar Weninger, Carl Tchagou, Andrew R. Marks
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Heart failure, the leading cause of mortality and morbidity in the developed world, is characterized by cardiac ryanodine receptor 2 channels that are hyperphosphorylated, oxidized, and depleted of the stabilizing subunit calstabin-2. This r
Externí odkaz:
https://doaj.org/article/bc2929b1c98e4fc79d74e5bb8c72f229
Autor:
Monia Souidi, Jessica Resta, Haikel Dridi, Yvonne Sleiman, Steve Reiken, Karina Formoso, Sarah Colombani, Pascal Amédro, Pierre Meyer, Azzouz Charrabi, Marie Vincenti, Yang Liu, Rajesh Kumar Soni, Frank Lezoualc'h, D.V.M. Stéphane Blot, François Rivier, Olivier Cazorla, Angelo Parini, Andrew R. Marks, Jeanne Mialet‐Perez, Alain Lacampagne, Albano C. Meli
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 2, Pp 536-551 (2024)
Abstract Background Duchenne muscular dystrophy (DMD) is an X‐linked disorder characterized by progressive muscle weakness due to the absence of functional dystrophin. DMD patients also develop dilated cardiomyopathy (DCM). We have previously shown
Externí odkaz:
https://doaj.org/article/86cf946208c7405482fdfb4f8454571b
Autor:
Yvonne Sleiman, Steven Reiken, Azzouz Charrabi, Fabrice Jaffré, Leah R. Sittenfeld, Jean-Luc Pasquié, Sarah Colombani, Bruce B. Lerman, Shuibing Chen, Andrew R. Marks, Jim W. Cheung, Todd Evans, Alain Lacampagne, Albano C. Meli
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Background Polymorphic ventricular tachycardia (PMVT) is a rare genetic disease associated with structurally normal hearts which in 8% of cases can lead to sudden cardiac death, typically exercise-induced. We previously showed a link between
Externí odkaz:
https://doaj.org/article/b2abf9b16f7f43bea357aaac1049831c
Autor:
Joshua J. Todd, Tokunbor A. Lawal, Irene C. Chrismer, Angela Kokkinis, Christopher Grunseich, Minal S. Jain, Melissa R. Waite, Victoria Biancavilla, Shavonne Pocock, Kia Brooks, Christopher J. Mendoza, Gina Norato, Ken Cheung, Willa Riekhof, Pooja Varma, Claudia Colina-Prisco, Magalie Emile-Backer, Katherine G. Meilleur, Andrew R. Marks, Yael Webb, Eugene E. Marcantonio, A. Reghan Foley, Carsten G. Bönnemann, Payam Mohassel
Publikováno v:
EClinicalMedicine, Vol 68, Iss , Pp 102433- (2024)
Summary: Background: RYR1-related myopathies (RYR1-RM) are caused by pathogenic variants in the RYR1 gene which encodes the type 1 ryanodine receptor (RyR1). RyR1 is the sarcoplasmic reticulum (SR) calcium release channel that mediates excitation-con
Externí odkaz:
https://doaj.org/article/eaee208d483c458182ce30c47fd601c7
Autor:
Haikel Dridi, Gaetano Santulli, Laith Bahlouli, Marco C. Miotto, Gunnar Weninger, Andrew R. Marks
Publikováno v:
Biomolecules, Vol 13, Iss 9, p 1409 (2023)
Heart failure is a serious global health challenge, affecting more than 6.2 million people in the United States and is projected to reach over 8 million by 2030. Independent of etiology, failing hearts share common features, including defective calci
Externí odkaz:
https://doaj.org/article/048e4c96f40545ac849ee913a8e67a7a
Autor:
Andrew R. Marks
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 2 (2023)
This Review provides an update on ryanodine receptors (RyRs) and their role in human diseases of heart, muscle, and brain. Calcium (Ca2+) is a requisite second messenger in all living organisms. From C. elegans to mammals, Ca2+ is necessary for locom
Externí odkaz:
https://doaj.org/article/bd37eca3c6224763a0ec6f42b2fe7cda
Autor:
Haikel Dridi, Gaetano Santulli, Jessica Gambardella, Stanislovas S. Jankauskas, Qi Yuan, Jingyi Yang, Steven Reiken, Xujun Wang, Anetta Wronska, Xiaoping Liu, Alain Lacampagne, Andrew R. Marks
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 4 (2022)
Patients with heart failure (HF) have augmented vascular tone, which increases cardiac workload, impairing ventricular output and promoting further myocardial dysfunction. The molecular mechanisms underlying the maladaptive vascular responses observe
Externí odkaz:
https://doaj.org/article/0a9867fb920b4c0a8a3138de89ee96cd
Autor:
Uma Mahesh R. Avula, Haikel Dridi, Bi-xing Chen, Qi Yuan, Alexander N. Katchman, Steven R. Reiken, Amar D. Desai, Samantha Parsons, Haajra Baksh, Elaine Ma, Parmanand Dasrat, Ruiping Ji, Yejun Lin, Christine Sison, W. Jonathan Lederer, Humberto C. Joca, Christopher W. Ward, Maura Greiser, Andrew R. Marks, Steven O. Marx, Elaine Y. Wan
Publikováno v:
JCI Insight, Vol 6, Iss 23 (2021)
Mechanistically driven therapies for atrial fibrillation (AF), the most common cardiac arrhythmia, are urgently needed, the development of which requires improved understanding of the cellular signaling pathways that facilitate the structural and ele
Externí odkaz:
https://doaj.org/article/b7be647bfebd45409f3562f2a31b359c
Autor:
Haikel Dridi, Xiaoping Liu, Qi Yuan, Steve Reiken, Mohamad Yehya, Leah Sittenfeld, Panagiota Apostolou, Julie Buron, Pierre Sicard, Stefan Matecki, Jérome Thireau, Clement Menuet, Alain Lacampagne, Andrew R. Marks
Publikováno v:
JCI Insight, Vol 5, Iss 19 (2020)
Huntington’s disease (HD) is a progressive, autosomal dominant neurodegenerative disorder affecting striatal neurons beginning in young adults with loss of muscle coordination and cognitive decline. Less appreciated is the fact that patients with H
Externí odkaz:
https://doaj.org/article/2571f7edb8e3450db13b03455d26d59d