Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Andrew R Burns"'
Autor:
Muntasir Kamal, Levon Tokmakjian, Jessica Knox, Duhyun Han, Houtan Moshiri, Lilia Magomedova, Ken Cq Nguyen, Hong Zheng, Andrew R Burns, Brittany Cooke, Jessica Lacoste, May Yeo, David H Hall, Carolyn L Cummins, Peter J Roy
Publikováno v:
PLoS Genetics, Vol 19, Iss 11, p e1011008 (2023)
The cuticles of ecdysozoan animals are barriers to material loss and xenobiotic insult. Key to this barrier is lipid content, the establishment of which is poorly understood. Here, we show that the p-glycoprotein PGP-14 functions coincidently with th
Externí odkaz:
https://doaj.org/article/5c781b6011f44da6a17ddfaf9152fdfb
Autor:
Muntasir Kamal, Jessica Knox, Robert I. Horne, Om Shanker Tiwari, Andrew R. Burns, Duhyun Han, Davide Levy, Dana Laor Bar-Yosef, Ehud Gazit, Michele Vendruscolo, Peter J. Roy
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Amyloids are associated with over 50 human diseases and have inspired significant effort to identify small molecule remedies. Here, we present an in vivo platform that efficiently yields small molecule inhibitors of amyloid formation. We pre
Externí odkaz:
https://doaj.org/article/32f38f45c042472bbab5c90925875d7e
Autor:
Andrew R Burns, Rachel Bagg, May Yeo, Genna M Luciani, Michael Schertzberg, Andy G Fraser, Peter J Roy
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 4, p e0005502 (2017)
Parasitic nematodes negatively impact human and animal health worldwide. The market withdrawal of nematicidal agents due to unfavourable toxicities has limited the available treatment options. In principle, co-administering nematicides at lower doses
Externí odkaz:
https://doaj.org/article/479bebb0fa464f03b6b3fe9c33211ac0
Autor:
Jessica Knox, Andrew R. Burns, Brittany Cooke, Savina R. Cammalleri, Megan Kitner, Justin Ching, Jack M. P. Castelli, Emily Puumala, Jamie Snider, Emily Koury, J. B. Collins, Salma Geissah, James J. Dowling, Erik C. Andersen, Igor Stagljar, Leah E. Cowen, Mark Lautens, Inga Zasada, Peter J. Roy
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Left unchecked, plant-parasitic nematodes have the potential to devastate crops globally. Highly effective but non-selective nematicides are justifiably being phased-out, leaving farmers with limited options for managing nematode infestation
Externí odkaz:
https://doaj.org/article/609af50dc9664af39474ef0017566555
Autor:
Sean Harrington, Jessica J. Knox, Andrew R. Burns, Ken-Loon Choo, Aaron Au, Megan Kitner, Cecile Haeberli, Jacob Pyche, Cassandra D’Amata, Yong-Hyun Kim, Jonathan R. Volpatti, Maximillano Guiliani, Jamie Snider, Victoria Wong, Bruna M. Palmeira, Elizabeth M. Redman, Aditya S. Vaidya, John S. Gilleard, Igor Stagljar, Sean R. Cutler, Daniel Kulke, James J. Dowling, Christopher M. Yip, Jennifer Keiser, Inga Zasada, Mark Lautens, Peter J. Roy
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
A C. elegans-based screening approach identifies nementin as a nematode-selective nematicide that can be used synergistically with acetylcholinesterase inhibitors
Externí odkaz:
https://doaj.org/article/b2ae40e60cd44727b137593ac69b190f
Autor:
Andrew R. Burns, Rachel J. Baker, Megan Kitner, Jessica Knox, Brittany Cooke, Jonathan R. Volpatti, Aditya S. Vaidya, Emily Puumala, Bruna M. Palmeira, Elizabeth M. Redman, Jamie Snider, Sagar Marwah, Sai W. Chung, Margaret H. MacDonald, Jens Tiefenbach, Chun Hu, Qi Xiao, Constance A. M. Finney, Henry M. Krause, Sonya A. MacParland, Igor Stagljar, John S. Gilleard, Leah E. Cowen, Susan L. F. Meyer, Sean R. Cutler, James J. Dowling, Mark Lautens, Inga Zasada, Peter J. Roy
Publikováno v:
Nature. 618:102-109
Autor:
Sean Harrington, Jacob Pyche, Andrew R. Burns, Tina Spalholz, Kaetlyn T. Ryan, Rachel J. Baker, Justin Ching, Lucien Rufener, Mark Lautens, Daniel Kulke, Alexandre Vernudachi, Mostafa Zamanian, Winnie Deuther-Conrad, Peter Brust, Peter J. Roy
Publikováno v:
Nature Communications 14(2023), 1816
Nematode parasites of humans and livestock pose a significant burden to human health, economic development, and food security. Anthelmintic drug resistance is widespread among parasites of livestock and many nematode parasites of humans lack effectiv
Autor:
Raphael Loll-Krippleber, Victoria A. Sajtovich, Michael W. Ferguson, Brandon Ho, Andrew R. Burns, Brandon J. Payliss, Joseph Bellissimo, Sydney Peters, Peter J. Roy, Haley D. M. Wyatt, Grant W. Brown
Publikováno v:
Microbial Cell Factories. 21
Background Over the 70 years since the introduction of plastic into everyday items, plastic waste has become an increasing problem. With over 360 million tonnes of plastics produced every year, solutions for plastic recycling and plastic waste reduct
Autor:
Sean Harrington, Jacob Pyche, Andrew R. Burns, Tina Spalholz, Rachel J. Baker, Justin Ching, Mark Lautens, Daniel Kulke, Winnie Deuther-Conrad, Peter Brust, Peter J. Roy
Nematode parasites of humans and livestock pose a significant burden to human health, economic development, and food security. Anthelmintic drug resistance is widespread among parasites of livestock and many nematode parasites of humans lack effectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aec86269fa1c62955421c2579abac7a3
https://doi.org/10.1101/2022.06.14.496146
https://doi.org/10.1101/2022.06.14.496146
Autor:
Muntasir Kamal, Jessica Knox, Duhyun Han, Andrew R. Burns, Ken CQ Nguyen, David H. Hall, Peter J. Roy
Understanding how to pharmacologically manipulate amyloids is an essential step towards managing dozens of amyloid-based human diseases. Here, we present a pipeline that yields small molecule antagonists of amyloidogenesis. Screens for small molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6940da8b01e6de600b145709f8d89379
https://doi.org/10.1101/2022.04.11.487937
https://doi.org/10.1101/2022.04.11.487937