Zobrazeno 1 - 2
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pro vyhledávání: '"Andrew R, Stiff"'
Publikováno v:
Journal of Leukocyte Biology. 113:518-524
Epigenetic therapy is an emerging field in the treatment of human cancer, including hematologic malignancies. This class of therapeutic agents approved by the US Food and Drug Administration for cancer treatment includes DNA hypomethylating agents, h
Autor:
Joseph, Markowitz, Tapas K, Mal, Chunhua, Yuan, Nicholas B, Courtney, Mitra, Patel, Andrew R, Stiff, James, Blachly, Christopher, Walker, Ann-Kathrin, Eisfeld, Albert, de la Chapelle, William E, Carson
Publikováno v:
Protein science : a publication of the Protein Society. 25(5)
It was recently discovered that the NRAS isoform 5 (20 amino acids) is expressed in melanoma and results in a more aggressive cell phenotype. This novel isoform is responsible for increased phosphorylation of downstream targets such as AKT, MEK, and