Zobrazeno 1 - 10
of 186
pro vyhledávání: '"Andrew Pospisilik"'
Autor:
Luca Fagnocchi, Stefan Fichtner-Feigl, Stephan Herrmann, Mira Fink, Jodok Fink, Claudia Lässle, Goran Marjanovic, J Andrew Pospisilik, Gabriel Seifert
Publikováno v:
BMJ Open, Vol 14, Iss 6 (2024)
Objectives To investigate the association of parental obesity (PO) with onset of obesity, pre-surgical disease duration and body mass index (BMI) at the time of surgery in patients undergoing metabolic-bariatric surgery (MBS).Design This is a cohort
Externí odkaz:
https://doaj.org/article/45cf253ab07e44cead1b9cc8a888a163
Autor:
Gabriel Seifert, Luca Fagnocchi, Michael Edozie, Stephan Herrmann, Hannah Baumann, Ilaria Panzeri, Stephanie Mewes, David Aicher, Mira Runkel, Claudia Lässle, Jodok Fink, Goran Marjanovic, Stephan Fichtner-Feigl, J. Andrew Pospisilik
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Obesity is a chronic, multifactorial disease which is linked to a number of adverse endocrinological and metabolic conditions. Currently, bariatric surgery is one of the most effective treatments for individuals diagnosed with severe obesity
Externí odkaz:
https://doaj.org/article/919b0abf752d4a5c96b673e426dacacd
Autor:
Tim Gruber, Franziska Lechner, Cahuê Murat, Raian E. Contreras, Eva Sanchez-Quant, Viktorian Miok, Konstantinos Makris, Ophélia Le Thuc, Ismael González-García, Elena García-Clave, Ferdinand Althammer, Quirin Krabichler, Lisa M. DeCamp, Russell G. Jones, Dominik Lutter, Rhiannan H. Williams, Paul T. Pfluger, Timo D. Müller, Stephen C. Woods, John Andrew Pospisilik, Celia P. Martinez-Jimenez, Matthias H. Tschöp, Valery Grinevich, Cristina García-Cáceres
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113305- (2023)
Summary: Oxytocin-expressing paraventricular hypothalamic neurons (PVNOT neurons) integrate afferent signals from the gut, including cholecystokinin (CCK), to adjust whole-body energy homeostasis. However, the molecular underpinnings by which PVNOT n
Externí odkaz:
https://doaj.org/article/90782dfc60ca478ea59744d818a5084b
Autor:
Irene Cimino, Debra Rimmington, Y. C. Loraine Tung, Katherine Lawler, Pierre Larraufie, Richard G. Kay, Samuel Virtue, Brian Y. H. Lam, Luca Fagnocchi, Marcella K. L. Ma, Vladimir Saudek, Ilona Zvetkova, Antonio Vidal-Puig, Giles S. H. Yeo, I. Sadaf Farooqi, J. Andrew Pospisilik, Fiona M. Gribble, Frank Reimann, Stephen O’Rahilly, Anthony P. Coll
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Neuronatin (Nnat) has previously been reported to be part of a network of imprinted genes downstream of the chromatin regulator Trim28. Disruption of Trim28 or of members of this network, including neuronatin, results in an unusual phenotype
Externí odkaz:
https://doaj.org/article/e7d5a888c2a540aeac4077803967b5d5
Autor:
Lucas Stetzik, Gabriela Mercado, Lindsey Smith, Sonia George, Emmanuel Quansah, Katarzyna Luda, Emily Schulz, Lindsay Meyerdirk, Allison Lindquist, Alexis Bergsma, Russell G. Jones, Lena Brundin, Michael X. Henderson, John Andrew Pospisilik, Patrik Brundin
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
There is growing evidence for the key role of microglial functional state in brain pathophysiology. Consequently, there is a need for efficient automated methods to measure the morphological changes distinctive of microglia functional states in resea
Externí odkaz:
https://doaj.org/article/1bddc0e28bb347448bdadb55a853f2cb
Autor:
Amanda R. Burmeister, Juozas Gordevicius, Emmanuel N. Paul, Christina Houck, Sonia George, Martha L. Escobar Galvis, Qiong Sha, Patrik Brundin, J. Andrew Pospisilik, Karen Racicot, Lena Brundin
Publikováno v:
Neurobiology of Disease, Vol 169, Iss , Pp 105720- (2022)
Background: Motor symptoms of Parkinson's disease (PD) are apparent after a high proportion of dopamine neurons in the substantia nigra have degenerated. The vast majority of PD cases are sporadic, and the underlying pathobiological causes are poorly
Externí odkaz:
https://doaj.org/article/c7cd84c1b4184a4e8749104cca618b17
Autor:
Kevin R Costello, Amy Leung, Candi Trac, Michael Lee, Mudaser Basam, J Andrew Pospisilik, Dustin E Schones
Publikováno v:
eLife, Vol 10 (2021)
Transposable elements (TEs) are mobile genetic elements that make up a large fraction of mammalian genomes. While select TEs have been co-opted in host genomes to have function, the majority of these elements are epigenetically silenced by DNA methyl
Externí odkaz:
https://doaj.org/article/55ac6a019e3446ad92dcb3e7b15bda15
Autor:
Wouter Peelaerts, Gabriela Mercado, Sonia George, Marie Villumsen, Alysa Kasen, Miguel Aguileta, Christian Linstow, Alexandra B. Sutter, Emily Kuhn, Lucas Stetzik, Rachel Sheridan, Liza Bergkvist, Lindsay Meyerdirk, Allison Lindqvist, Martha L. Escobar Gavis, Chris Van den Haute, Scott J. Hultgren, Veerle Baekelandt, J. Andrew Pospisilik, Tomasz Brudek, Susana Aznar, Jennifer A. Steiner, Michael X. Henderson, Lena Brundin, Magdalena I. Ivanova, Tom J. Hannan, Patrik Brundin
Publikováno v:
Acta Neuropathologica. 145:541-559
Symptoms in the urogenital organs are common in multiple system atrophy (MSA), also in the years preceding the MSA diagnosis. It is unknown how MSA is triggered and these observations in prodromal MSA led us to hypothesize that synucleinopathy could
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba8e06332a93b1806d5f43f520590e9c
https://doi.org/10.1007/s00401-023-02562-4
https://doi.org/10.1007/s00401-023-02562-4
Autor:
Mira Fink, Stephan Herrmann, Jodok Fink, Claudia Lässle, Goran Marjanovic, Luca Fagnocchi, J. Andrew Pospisilik, Stefan Fichtner-Feigl, Gabriel Seifert
Publikováno v:
Obesity Surgery. 33:1519-1527
Introduction Parental predisposition and age of onset may be independently associated with 1-year total weight loss (TWL) failure ( Methods This cohort study includes all cases of the German StuDoQ|MBE register (2015–2019) with data on parental pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78e1759d52b9d97fb33bd966c48e0f63
https://doi.org/10.1007/s11695-023-06499-1
https://doi.org/10.1007/s11695-023-06499-1
Autor:
Dominika Nackiewicz, Meixia Dan, Madeleine Speck, Samuel Z. Chow, Yi-Chun Chen, J. Andrew Pospisilik, C. Bruce Verchere, Jan A. Ehses
Publikováno v:
iScience, Vol 23, Iss 1, Pp - (2020)
Summary: Macrophages play a dynamic role in tissue repair following injury. Here we found that following streptozotocin (STZ)-induced beta-cell death, mouse islet macrophages had increased Igf1 expression, decreased proinflammatory cytokine expressio
Externí odkaz:
https://doaj.org/article/185474ae2b97478a94b428034c20b27a