Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Andrew Phimister"'
Autor:
Sean B. Joseph, Paul Vincent Rucker, Peter McNamara, Michael Badman, Todd Groessl, Chianelli Donatella, Bo Liu, Alan Chu, Yugang Liu, Badry Bursulaya, H. Martin Seidel, Young Kim, John Nelson, Valentina Molteni, David C. Tully, David J Huang, Wendy Richmond, Andrew Phimister, Dingjiu Bao, Jane Wu, Thierry Schlama, Jason Roland, Eloy D. Hernandez, Bryan Laffitte, Jocelyn Zoll, Mahavir Prashad, Ignacio Sancho-Martinez, Robert Hill, Xiaodong Liu, James Schmeits
Publikováno v:
Journal of medicinal chemistry. 63(8)
Farnesoid X receptor (FXR) agonists are emerging as important potential therapeutics for the treatment of nonalcoholic steatohepatitis (NASH) patients, as they exert positive effects on multiple aspects of the disease. FXR agonists reduce lipid accum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::308b3ff9affec6142819020e4a0d2b6c
https://pubmed.ncbi.nlm.nih.gov/31940200
https://pubmed.ncbi.nlm.nih.gov/31940200
Autor:
Young Kim, Tove Tuntland, H. Martin Seidel, Thomas H. Marsilje, Nanxin Li, Wei Pei, You-Qun He, Xiaoming Cui, Wendy Richmond, Markus Warmuth, Auzon Steffy, Alex Aycinena, Sungjoon Kim, W. Perry Gordon, Donald S. Karanewsky, AnneMarie Culazzo Pferdekamper, Jin Yunho, Jonathan Chang, Ruo Steensma, Jennifer L. Harris, Bo Liu, Sean B. Joseph, Yelena Sarkisova, Christian C. Lee, Todd Groessl, Bei Chen, Wenshuo Lu, Chopiuk Greg, Tao Jiang, Kevin Johnson, Tetsuo Uno, Pierre-Yves Michellys, Jiqing Jiang, Andrew Phimister, Allen G. Li, Nathanael S. Gray, Badry Bursulaya, Frank Sun, Yongqin Wan, Jie Li
Publikováno v:
Journal of Medicinal Chemistry. 56:5675-5690
The synthesis, preclinical profile, and in vivo efficacy in rat xenograft models of the novel and selective anaplastic lymphoma kinase inhibitor 15b (LDK378) are described. In this initial report, preliminary structure–activity relationships (SARs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d85881c6ed23d1f9f401bd84a59439c2
https://doi.org/10.1021/jm400402q
https://doi.org/10.1021/jm400402q
Publikováno v:
Tetrahedron Letters. 40:8515-8518
Measurements on eighteen 13COOH-labeled acids, including hydrogen-bonded and non-hydrogen-bonded standards are self-consistent and suggest strongly that the aqueous pKas of bilirubin are within the normal range for aliphatic carboxylic acids. Our emp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22e5d0b7cae8e694bec7fead005a19a5
https://doi.org/10.1016/s0040-4039(99)01841-9
https://doi.org/10.1016/s0040-4039(99)01841-9
Autor:
Thomas H, Marsilje, Wei, Pei, Bei, Chen, Wenshuo, Lu, Tetsuo, Uno, Yunho, Jin, Tao, Jiang, Sungjoon, Kim, Nanxin, Li, Markus, Warmuth, Yelena, Sarkisova, Frank, Sun, Auzon, Steffy, AnneMarie C, Pferdekamper, Allen G, Li, Sean B, Joseph, Young, Kim, Bo, Liu, Tove, Tuntland, Xiaoming, Cui, Nathanael S, Gray, Ruo, Steensma, Yongqin, Wan, Jiqing, Jiang, Greg, Chopiuk, Jie, Li, W Perry, Gordon, Wendy, Richmond, Kevin, Johnson, Jonathan, Chang, Todd, Groessl, You-Qun, He, Andrew, Phimister, Alex, Aycinena, Christian C, Lee, Badry, Bursulaya, Donald S, Karanewsky, H Martin, Seidel, Jennifer L, Harris, Pierre-Yves, Michellys
Publikováno v:
Journal of medicinal chemistry. 56(14)
The synthesis, preclinical profile, and in vivo efficacy in rat xenograft models of the novel and selective anaplastic lymphoma kinase inhibitor 15b (LDK378) are described. In this initial report, preliminary structure-activity relationships (SARs) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dbf15d2b63a657b955fb85a1fda7239b
https://pubmed.ncbi.nlm.nih.gov/23837797
https://pubmed.ncbi.nlm.nih.gov/23837797