Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Andrew Patron"'
Autor:
Donald S. Karanewsky, Guy Servant, Hanghui Liu, Bert Chi, Lily Ida, Michael Saganich, Sara Werner, Joseph R. Fotsing, Andrew Patron, Catherine Tachdjian, Amy Arthur
Publikováno v:
Toxicology Reports, Vol 4, Iss , Pp 507-520 (2017)
A toxicological evaluation of N-(1-((4-amino-2,2-dioxido-1H-benzo[c][1,2,6]thiadiazin-5-yl)oxy)-2-methylpropan-2-yl)-2,6-dimethylisonicotinamide (S2218; CAS 1622458-34-7), a flavour with modifying properties, was completed for the purpose of assessin
Externí odkaz:
https://doaj.org/article/e104bf811a6b41778b1fd0b467f96e72
Publikováno v:
Journal of chromatography. A. 1632
We describe a simple and effective approach to probe adduct formation in liquid chromatography - electrospray ionization mass spectrometry (LC-ESI-MS) and help designate and/or confirm which particular analyte is leading to which particular charged s
Autor:
Lan Zhang, Hanghui Liu, Brett Weylan Ching, Guy Servant, Tanya Ditschun, Andrew Patron, Thomas Brady, Mark C. Williams, Melissa Arellano, Vincent Darmohusodo, Michael Saganich, Qing Chen, Timothy Davis, Catherine Tachdjian, Donald S. Karanewsky, Joseph R. Fotsing
Publikováno v:
Journal of medicinal chemistry. 63(9)
In humans, bitter taste is mediated by 25 TAS2Rs. Many compounds, including certain active pharmaceutical ingredients, excipients, and nutraceuticals, impart their bitter taste (or in part) through TAS2R8 activation. However, effective TAS2R8 blocker
Autor:
Faber Nathan, Alain Noncovich, Guy Servant, Nicole Gonsalves, Paul Brust, Tanya Ditschun, Jane Ung, Andrew Patron, Hanghui Liu, Nicole Servant, Chad Priest
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:3931-3938
The paper presents the activity trends for a novel series of phenoxyacetyl amides as human TRPM8 receptor agonists. This series encompasses in vitro activity values ranging from the micromolar to the picomolar levels. Sensory evaluation of these mole
Autor:
Bert Chi, Andrew Patron, Michael Saganich, Sara Werner, Catherine Tachdjian, Guy Servant, Amy J. Arthur, Joseph R. Fotsing, Lily Ida, Hanghui Liu, Donald S. Karanewsky
Publikováno v:
Toxicology Reports, Vol 4, Iss, Pp 507-520 (2017)
Toxicology Reports
Toxicology Reports
Graphical abstract The results of the ADME, genotoxicity, rodent toxicology and developmental toxicology studies conducted on a new flavour compound S2218 are reported. S2218 is a positive allosteric modifier (PAM) of the human sweet taste receptor a
Publikováno v:
Tetrahedron Letters. 56:4836-4839
We report the total synthesis of NP-011694, a previously unreported fungal fermentation product from Analyticon Gmbh. The convergent synthesis employs Turbo Grignard and lithiation strategies, along with novel conditions for the simultaneous removal
Publikováno v:
ChemInform. 46
We report the total synthesis of NP-011694, a previously unreported fungal fermentation product from Analyticon Gmbh. The convergent synthesis employs Turbo Grignard and lithiation strategies, along with novel conditions for the simultaneous removal
Autor:
Fernando Echeverri, Bianca Laita, Hong Xu, Raymond D. Smith, Nancy Hwang, Peter H. Li, Walter Keung, Lena Staszewski, Erika Patron, Andrew Patron, Jing Ling, Rachel D.A. Kimmich, Min Lu, Bryan D. Moyer, David Dahan, Dalia Kalabat, Jeff Yamamoto
Publikováno v:
Journal of Biological Chemistry. 283:11981-11994
The epithelial sodium channel (ENaC), a heterotrimeric complex composed of alpha, beta, and gamma subunits, belongs to the ENaC/degenerin family of ion channels and forms the principal route for apical Na(+) entry in many reabsorbing epithelia. Altho