Výsledky vyhledávání - "Andrew Paluch"

Predicting Octanol/water Partition Coefficients Using Molecular Simulation for the SAMPL7 Challenge: Comparing the Use of Neat and Water Saturated 1-Octanol

Autor: Spencer J. Sabatino, Andrew Paluch

Blind predictions of octanol/water partition coefficients at 298 K for 22 drug-like compounds were made for the SAMPL7 challenge. The octanol/water partition coefficients were predicted using solvation free energies computed using molecular dynamics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01528826fa6ce1c84708a4a18643ac7e
https://doi.org/10.26434/chemrxiv.14529861

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Predicting the Solubility of Nonelectrolyte Solids Using a Combination of Molecular Simulation with the Solubility Parameter Method MOSCED: Application to the Wastewater Contaminants Monuron, Diuron, Atrazine and Atenolol

Autor: Rachel Ollier, Thomas Nguyen, Hrithik Agarwal, Jeremy Phifer, Larissa Ferreira da Silva, Gabriel Gonçalves Nogueira, Ana Pereira Barbosa, Ryan Ley, Elizabeth O’Loughlin, Brett Rygelski, Spencer Sabatino, Andrew Paluch

Publikováno v: Processes; Volume 10; Issue 3; Pages: 538

Methods to predict the equilibrium solubility of nonelectrolyte solids are indispensable for early-stage process development, design, and feasibility studies. Conventional analytic methods typically require reference data to regress parameters, which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::201f95eceb7135268f0b524183675879
https://doi.org/10.3390/pr10030538

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Safety and efficacy of AMG 160, a half-life extended BiTE immune therapy targeting prostate-specific membrane antigen (PSMA), and other therapies for metastatic castration-resistant prostate cancer (mCRPC)

Autor: Camila Jhones, Joseph Maly, Lakshminarayanan Nandagopal, Sumit K. Subudhi, Freda Cooner, Andrew Paluch, Young E. Whang, Anthony M. Joshua, Mark Salvati, Hosein Kouros-Mehr, Vinita Gupta, Rahul Aggarwal, Xianne Penny, Mukul Minocha, Johann S. de Bono, Bilal A. Siddiqui, Tobias Eggert, Margit Janat-Amsbury, Elaine T. Lam

Publikováno v: Journal of Clinical Oncology. 39:TPS5088-TPS5088

TPS5088 Background: Lesions in mCRPC are typically immunologically cold. AMG 160 binds to PSMA on cancer cells and CD3 on T cells, leading to T-cell infiltration, activation, expansion, and tumor cell killing. In a first-in-human study, AMG 160 has d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b84c95121e226a12e008d314b133e9e3
https://doi.org/10.1200/jco.2021.39.15_suppl.tps5088

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