Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Andrew P. Turnbull"'
Autor:
E Josue Ruiz, Adan Pinto-Fernandez, Andrew P Turnbull, Linxiang Lan, Thomas M Charlton, Hannah C Scott, Andreas Damianou, George Vere, Eva M Riising, Clive Da Costa, Wojciech W Krajewski, David Guerin, Jeffrey D Kearns, Stephanos Ioannidis, Marie Katz, Crystal McKinnon, Jonathan O'Connell, Natalia Moncaut, Ian Rosewell, Emma Nye, Neil Jones, Claire Heride, Malte Gersch, Min Wu, Christopher J Dinsmore, Tim R Hammonds, Sunkyu Kim, David Komander, Sylvie Urbe, Michael J Clague, Benedikt M Kessler, Axel Behrens
Publikováno v:
eLife, Vol 10 (2021)
Lung squamous cell carcinoma (LSCC) is a considerable global health burden, with an incidence of over 600,000 cases per year. Treatment options are limited, and patient’s 5-year survival rate is less than 5%. The ubiquitin-specific protease 28 (USP
Externí odkaz:
https://doaj.org/article/eeea231092ca40e880a44f8ed5d20d8d
Autor:
Martin L. Stockley, Amanda Ferdinand, Giovanni Benedetti, Peter Blencowe, Susan M. Boyd, Mat Calder, Mark D. Charles, Lucy V. Edwardes, Tennyson Ekwuru, Harry Finch, Alessandro Galbiati, Lerin Geo, Diego Grande, Vera Grinkevich, Nicholas D. Holliday, Wojciech W. Krajewski, Ellen MacDonald, Jayesh B. Majithiya, Hollie McCarron, Claire L. McWhirter, Viral Patel, Chris Pedder, Eeson Rajendra, Marco Ranzani, Laurent J. M. Rigoreau, Helen M. R. Robinson, Theresia Schaedler, Julija Sirina, Graeme C. M. Smith, Martin E. Swarbrick, Andrew P. Turnbull, Simon Willis, Robert A. Heald
Publikováno v:
Journal of Medicinal Chemistry. 65:13879-13891
Human DNA polymerase theta (Polθ), which is essential for microhomology-mediated DNA double strand break repair, has been proposed as an attractive target for the treatment of BRCA deficient and other DNA repair pathway defective cancers. As previou
Autor:
Gudrun Schober, Myrtha Arnold, Susan Birtles, Linda K. Buckett, Gustavo Pacheco-López, Andrew V. Turnbull, Wolfgang Langhans, Abdelhak Mansouri
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 5, Pp 1369-1384 (2013)
Acyl CoA:diacylglycerol acyltransferase-1 (DGAT-1) catalyzes the final step in triacylglycerol (TAG) synthesis and is highly expressed in the small intestine. Because DGAT-1 knockout mice are resistant to diet-induced obesity, we investigated the acu
Externí odkaz:
https://doaj.org/article/594a4e189aff489092aac246d741530b
Autor:
Gene P. Ables, Kryscilla Jian Zhang Yang, Silke Vogel, Antonio Hernandez-Ono, Shuiqing Yu, Jason J. Yuen, Susan Birtles, Linda K. Buckett, Andrew V. Turnbull, Ira J. Goldberg, William S. Blaner, Li-Shin Huang, Henry N. Ginsberg
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 11, Pp 2364-2379 (2012)
Acyl CoA:diacylglycerol acyltransferase (DGAT) 1 catalyzes the final step of triglyceride (TG) synthesis. We show that acute administration of a DGAT1 inhibitor (DGAT1i) by oral gavage or genetic deletion of intestinal Dgat1 (intestine-Dgat1−/−)
Externí odkaz:
https://doaj.org/article/ef0ae0cad15247f89a3efeb1b1b8818c
Autor:
Li Liu, Shuiqing Yu, Raffay S. Khan, Gene P. Ables, Kalyani G. Bharadwaj, Yunying Hu, Lesley A. Huggins, Jan W. Eriksson, Linda K. Buckett, Andrew V. Turnbull, Henry N. Ginsberg, William S. Blaner, Li-Shin Huang, Ira J. Goldberg
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 4, Pp 732-744 (2011)
Diacylglycerol (DAG) acyl transferase 1 (Dgat1) knockout (−/−) mice are resistant to high-fat-induced obesity and insulin resistance, but the reasons are unclear. Dgat1−/− mice had reduced mRNA levels of all three Ppar genes and genes involve
Externí odkaz:
https://doaj.org/article/28b9b4fb4e8e4a7880d03b89710adc64
Autor:
Axel Behrens, Clive Da Costa, Min Wu, David Joseph Guerin, Emma Nye, Jonathan O'Connell, Adan Pinto-Fernandez, Eva M. Riising, Jeffrey D Kearns, Tim Hammonds, Andrew P. Turnbull, Crystal McKinnon, E. Josue Ruiz, Claire Heride, Christopher J. Dinsmore, Malte Gersch, Ian Rosewell, Thomas M. Charlton, Linxiang Lan, Neil P. Jones, Andreas Damianou, Hannah C. Scott, Benedikt M. Kessler, Sylvie Urbé, Michael J. Clague, Natalia Moncaut, Wojciech W. Krajewski, Stephanos Ioannidis, David Komander, Marie Katz, Sunkyu Kim, George Vere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::205d91672bd258cadd1c178b2544807d
https://doi.org/10.7554/elife.71596.sa2
https://doi.org/10.7554/elife.71596.sa2
Autor:
Malte Gersch, Thomas M. Charlton, Michael J. Clague, Linxiang Lan, Hannah C. Scott, Sylvie Urbé, George Vere, Min Wu, Sunkyu Kim, Stephanos Ioannidis, Claire Heride, Jeffrey D Kearns, Jonathan O'Connell, David Komander, Adan Pinto-Fernandez, E. Josue Ruiz, Emma Nye, Axel Behrens, Benedikt M. Kessler, Andrew P. Turnbull, Marie Katz, Natalia Moncaut, Andreas Damianou, Wojciech W. Krajewski, Neil P. Jones, Christopher J. Dinsmore, Ian Rosewell, Tim Hammonds, David Joseph Guerin, Eva M. Riising, Crystal McKinnon, Clive Da Costa
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Lung squamous cell carcinoma (LSCC) is a considerable global health burden, with an incidence of over 600,000 cases per year. Treatment options are limited, and patient’s 5-year survival rate is less than 5%. The ubiquitin-specific protease 28 (USP
Autor:
Andrew P. Turnbull, Xiaoqiu Wu
Publikováno v:
Protein-Ligand Interactions ISBN: 9781071611968
A wide range of biological processes rely on complexes between ribonucleic acids (RNAs) and proteins. Determining the three-dimensional structures of RNA-protein complexes is crucial to elucidate the relationship between structure and biological func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8eef918fd5b1ee871ff125828324fdd
https://doi.org/10.1007/978-1-0716-1197-5_20
https://doi.org/10.1007/978-1-0716-1197-5_20
Autor:
Jack U Flanagan, Yuliana Yosaatmadja, Rebecca M Teague, Matilda Z L Chai, Andrew P Turnbull, Christopher J Squire
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43965 (2012)
Aldo-keto reductase 1C3 (AKR1C3) catalyses the NADPH dependent reduction of carbonyl groups in a number of important steroid and prostanoid molecules. The enzyme is also over-expressed in prostate and breast cancer and its expression is correlated wi
Externí odkaz:
https://doaj.org/article/7b40b3a682af4842b8a1418c97a7a97c
Publikováno v:
Journal of Optometry, Vol 6, Iss 3, Pp 173-174 (2013)
Externí odkaz:
https://doaj.org/article/3123f081b627414d83536dba077e3f5c