The DOE E3SM Coupled Model Version 1: Overview and Evaluation at Standard Resolution

Autor: Jean‐Christophe Golaz, Peter M. Caldwell, Luke P. Van Roekel, Mark R. Petersen, Qi Tang, Jonathan D. Wolfe, Guta Abeshu, Valentine Anantharaj, Xylar S. Asay‐Davis, David C. Bader, Sterling A. Baldwin, Gautam Bisht, Peter A. Bogenschutz, Marcia Branstetter, Michael A. Brunke, Steven R. Brus, Susannah M. Burrows, Philip J. Cameron‐Smith, Aaron S. Donahue, Michael Deakin, Richard C. Easter, Katherine J. Evans, Yan Feng, Mark Flanner, James G. Foucar, Jeremy G. Fyke, Brian M. Griffin, Cécile Hannay, Bryce E. Harrop, Mattthew J. Hoffman, Elizabeth C. Hunke, Robert L. Jacob, Douglas W. Jacobsen, Nicole Jeffery, Philip W. Jones, Noel D. Keen, Stephen A. Klein, Vincent E. Larson, L. Ruby Leung, Hong‐Yi Li, Wuyin Lin, William H. Lipscomb, Po‐Lun Ma, Salil Mahajan, Mathew E. Maltrud, Azamat Mametjanov, Julie L. McClean, Renata B. McCoy, Richard B. Neale, Stephen F. Price, Yun Qian, Philip J. Rasch, J. E. Jack Reeves Eyre, William J. Riley, Todd D. Ringler, Andrew F. Roberts, Erika L. Roesler, Andrew G. Salinger, Zeshawn Shaheen, Xiaoying Shi, Balwinder Singh, Jinyun Tang, Mark A. Taylor, Peter E. Thornton, Adrian K. Turner, Milena Veneziani, Hui Wan, Hailong Wang, Shanlin Wang, Dean N. Williams, Phillip J. Wolfram, Patrick H. Worley, Shaocheng Xie, Yang Yang, Jin‐Ho Yoon, Mark D. Zelinka, Charles S. Zender, Xubin Zeng, Chengzhu Zhang, Kai Zhang, Yuying Zhang, Xue Zheng, Tian Zhou, Qing Zhu

Publikováno v: Journal of Advances in Modeling Earth Systems, Vol 11, Iss 7, Pp 2089-2129 (2019)

Abstract This work documents the first version of the U.S. Department of Energy (DOE) new Energy Exascale Earth System Model (E3SMv1). We focus on the standard resolution of the fully coupled physical model designed to address DOE mission‐relevant

Externí odkaz: https://doaj.org/article/41308c66b425453fb24bef57ead160e2

Data from Transcriptional Activation of MYC-Induced Genes by GCN5 Promotes B-cell Lymphomagenesis

Autor: Sharon Y.R. Dent, Evangelia Koutelou, Kevin M. McBride, Yue Lu, Kevin Lin, Jianjun Shen, Andrew P. Salinger, Joshua B. Plummer, Aimee T. Farria

Overexpression of the MYC oncoprotein is an initiating step in the formation of several cancers. MYC frequently recruits chromatin-modifying complexes to DNA to amplify the expression of cancer-promoting genes, including those regulating cell cycle,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c688e7cbbacacf3a32981183c3959b68
https://doi.org/10.1158/0008-5472.c.6512584.v1

Transcriptional Activation of MYC-Induced Genes by GCN5 Promotes B-cell Lymphomagenesis

Autor: Yue Lu, Kevin M. McBride, Andrew P. Salinger, Evangelia Koutelou, Aimee T. Farria, Jianjun Shen, Joshua B. Plummer, Sharon Y.R. Dent, Kevin Lin

Publikováno v: Cancer Res

Overexpression of the MYC oncoprotein is an initiating step in the formation of several cancers. MYC frequently recruits chromatin-modifying complexes to DNA to amplify the expression of cancer-promoting genes, including those regulating cell cycle,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f12eab364a7dec6a67e84014cbc94f3
https://doi.org/10.1158/0008-5472.can-20-2379

Usp22 Overexpression Leads to Aberrant Signal Transduction of Cancer-Related Pathways but Is Not Sufficient to Drive Tumor Formation in Mice

Autor: Boyko S. Atanassov, Yue Lu, Sharon Y.R. Dent, Lisa Maria Mustachio, Kevin Lin, Ying-Jiun C. Chen, Andrew P. Salinger, Evangelia Koutelou, Timothy Macatee, Michael J McAndrew, Xianghong Kuang, Jianjun Shen

Publikováno v: Cancers
Volume 13
Issue 17
Cancers, Vol 13, Iss 4276, p 4276 (2021)

Simple Summary Increased levels of the Usp22 deubiquitinase have been observed in several types of human cancer, particularly highly aggressive, therapy-resistant tumors. However, the role of Usp22 overexpression in cancer etiology is not known. To a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77885f793105dfcbf0e1bbff31325267
https://doi.org/10.3390/cancers13174276

Mouse Mutagenesis Using N-Ethyl-N-Nitrosourea (ENU)

Autor: Andrew P, Salinger, Monica J, Justice

Publikováno v: CSH protocols. 2008

INTRODUCTIONThis protocol describes chemical mutagenesis of male mice using N-ethyl-N-nitrosourea (ENU), which is the most efficient method for obtaining mouse mutations in phenotype-driven screens. A fractionated dose of ENU, an alkylating agent, ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::81a7a397c4a71d7fa295c70a2248622f
https://pubmed.ncbi.nlm.nih.gov/21356809