Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Andrew P. Ryan"'
Autor:
Brian V. Tsu, Rimjhim Agarwal, Nandan S. Gokhale, Jessie Kulsuptrakul, Andrew P. Ryan, Elizabeth J. Fay, Lennice K. Castro, Christopher Beierschmitt, Christina Yap, Elizabeth A. Turcotte, Sofia E. Delgado-Rodriguez, Russell E. Vance, Jennifer L. Hyde, Ram Savan, Patrick S. Mitchell, Matthew D. Daugherty
Publikováno v:
PLoS Biology, Vol 21, Iss 6 (2023)
Hosts have evolved diverse strategies to respond to microbial infections, including the detection of pathogen-encoded proteases by inflammasome-forming sensors such as NLRP1 and CARD8. Here, we find that the 3CL protease (3CLpro) encoded by diverse c
Externí odkaz:
https://doaj.org/article/5dd514c3e9364ba18c660907120ad774
Autor:
Jacob D. Covert, Brian A. Grice, Matthew G. Thornburg, Manpreet Kaur, Andrew P. Ryan, Lixuan Tackett, Theja Bhamidipati, Natalie D. Stull, Teayoun Kim, Kirk M. Habegger, Donald A. McClain, Joseph T. Brozinick, Jeffrey S. Elmendorf
Publikováno v:
Molecular Metabolism, Vol 72, Iss , Pp 101715- (2023)
Objective: A buildup of skeletal muscle plasma membrane (PM) cholesterol content in mice occurs within 1 week of a Western-style high-fat diet and causes insulin resistance. The mechanism driving this cholesterol accumulation and insulin resistance i
Externí odkaz:
https://doaj.org/article/034b5171489647b9bf0aa2bbe510d46e
Publikováno v:
Pathogens, Vol 12, Iss 5, p 674 (2023)
Protein post-translational modifications (PTMs) are an important battleground in the evolutionary arms races that are waged between the host innate immune system and viruses. One such PTM, ADP-ribosylation, has recently emerged as an important mediat
Externí odkaz:
https://doaj.org/article/cd3324e4630c4d088e2931be8ab7a9fd
Autor:
Brenda M. McGrath, Linda Takamine, Cainnear K. Hogan, Timothy P. Hofer, Amy K. Rosen, Jeremy B. Sussman, Wyndy L. Wiitala, Andrew M. Ryan, Hallie C. Prescott
Publikováno v:
BMC Health Services Research, Vol 22, Iss 1, Pp 1-13 (2022)
Abstract Background Hospital-specific template matching (HS-TM) is a newer method of hospital performance assessment. Objective To assess the interpretability, credibility, and usability of HS-TM-based vs. regression-based performance assessments. Re
Externí odkaz:
https://doaj.org/article/321449bf9db8478b91a70660bf7ebcb2
Autor:
Donté Alexander Stevens, Christopher Beierschmitt, Swetha Mahesula, Miles R Corley, John Salogiannis, Brian V Tsu, Bryant Cao, Andrew P Ryan, Hiroyuki Hakozawki, Samara L Reck-Peterson, Matthew D Daugherty
Publikováno v:
eLife, Vol 11 (2022)
Viruses interact with the intracellular transport machinery to promote viral replication. Such host–virus interactions can drive host gene adaptation, leaving signatures of pathogen-driven evolution in host genomes. Here, we leverage these genetic
Externí odkaz:
https://doaj.org/article/e59611f3ae034a729149b9fc1746e00b
Autor:
Nicholas L. Berlin, MD, MPH, MS, Zoey Chopra, BA, Arrice Bryant, MD, MPH, Josh Agius, Simone R. Singh, PhD, Karan R. Chhabra, MD, MS, Paul Schulz, MA, Brady T. West, PhD, Andrew M. Ryan, PhD, Jeffrey T. Kullgren, MD, MS, MPH
Publikováno v:
Annals of Surgery Open, Vol 3, Iss 2, p e162 (2022)
Objective:. To estimate the nationwide prevalence of individualized out-of-pocket (OOP) price estimators at US hospitals, characterize patterns of inclusion of 14 specified “shoppable” surgical procedures, and determine hospital-level characteris
Externí odkaz:
https://doaj.org/article/d80c5fcc92e9485e96c88faad45f1d63
Autor:
Hanna Zlotnick, Geoffrey J. Hoffman, Ushapoorna Nuliyalu, Tedi A. Engler, Kenneth M. Langa, Andrew M. Ryan
Publikováno v:
BMC Health Services Research, Vol 20, Iss 1, Pp 1-9 (2020)
Abstract Background To evaluate the association between social capital and 30-day readmission to the hospital among Medicare beneficiaries overall, beneficiaries with dementia and related memory disorders, and beneficiaries with dual eligibility for
Externí odkaz:
https://doaj.org/article/3fbf84471d89471ea46e1896a7cbce56
Autor:
Brian V Tsu, Christopher Beierschmitt, Andrew P Ryan, Rimjhim Agarwal, Patrick S Mitchell, Matthew D Daugherty
Publikováno v:
eLife, Vol 10 (2021)
The NLRP1 inflammasome is a multiprotein complex that is a potent activator of inflammation. Mouse NLRP1B can be activated through proteolytic cleavage by the bacterial Lethal Toxin (LeTx) protease, resulting in degradation of the N-terminal domains
Externí odkaz:
https://doaj.org/article/4a963c5b452f4d9c88a2a2ddfa16fdf1
Autor:
Wenshuo Liu, Cooper Stansbury, Karandeep Singh, Andrew M Ryan, Devraj Sukul, Elham Mahmoudi, Akbar Waljee, Ji Zhu, Brahmajee K Nallamothu
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0221606 (2020)
Reducing unplanned readmissions is a major focus of current hospital quality efforts. In order to avoid unfair penalization, administrators and policymakers use prediction models to adjust for the performance of hospitals from healthcare claims data.
Externí odkaz:
https://doaj.org/article/06fc0246c072463f9ed20f9c89814276
Autor:
Navneet Kaur Baidwan, Susan G. Gerberich, Hyun Kim, Andrew D. Ryan, Timothy R. Church, Benjamin Capistrant
Publikováno v:
Injury Epidemiology, Vol 5, Iss 1, Pp 1-9 (2018)
Abstract Background Age may affect one’s susceptibility to the myriad physical hazards that may pose risks for work-related injuries. Aging workers are not only at risk for work-related injuries but, also, at even higher risk for more severe health
Externí odkaz:
https://doaj.org/article/0c539822ee354b1ea4c421a76d177dcb