Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Andrew P. Norman"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract The cocaine unit dose–response function is an inverted U with the ascending and descending limbs representing the positive and rate limiting cocaine effects, respectively. Higher fixed ratio (FR) schedules and/or time-out periods make the
Externí odkaz:
https://doaj.org/article/f33345e8642343b3bb74688d2a16a19c
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract In rats that self-administer cocaine, the latency to the reinstatement of lever pressing behavior induced by a single dose of cocaine is due to the time taken for cocaine levels to fall to the satiety threshold. The D1 dopamine receptor anta
Externí odkaz:
https://doaj.org/article/de1a3376fc14486db11a0d4898f9b30a
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 19, Iss 3 (2023)
ABSTRACTA humanized monoclonal antibody h2E2 designed to bind cocaine with high affinity, specificity, and a long half-life (~7 d in rats) is being developed as a treatment for cocaine use disorder. We report here a pharmacokinetic (PK) study of h2E2
Externí odkaz:
https://doaj.org/article/11df4beb242d4c0db3e7dcfdfd587cab
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Progressive ratio (PR) schedules of drug delivery are used to determine the ‘motivational’ state of an animal and drug ‘reinforcing efficacy’. This widely held interpretation is supported mainly by the observation that the PR breakpo
Externí odkaz:
https://doaj.org/article/4d9b70cdc7fa418798c70944cfe08a2d
Autor:
Terence L. Kirley, Andrew B. Norman
Publikováno v:
Biochemistry and Biophysics Reports, Vol 35, Iss , Pp 101520- (2023)
Fluorescein isothiocyanate (FITC) is widely used to fluorescently label reactive lysine residues on proteins, including antibodies. The rate and extent of labeling varies with reaction conditions, concentration of label, and the concentration and nat
Externí odkaz:
https://doaj.org/article/a19ddb72fc3b4d09aa9db90cc65c8d77
Publikováno v:
Heliyon, Vol 9, Iss 7, Pp e17988- (2023)
A single non-contingent dose of cocaine reinstates extinguished lever pressing behavior in rats trained to self-administer cocaine. This represents a model of relapse in cocaine use disorder and the number of lever presses has been the standard measu
Externí odkaz:
https://doaj.org/article/b5a0d9e4b135485186615f36c049b241
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract According to pharmacological theory, the magnitude of an agonist-induced response is related to the number of receptors occupied. If there is a receptor reserve, when the number of receptors is altered the fractional occupancy required to ma
Externí odkaz:
https://doaj.org/article/6588c02fe44b498cada5dc7949b74f17
Publikováno v:
Pharmacology Research & Perspectives, Vol 11, Iss 1, Pp n/a-n/a (2023)
Abstract The recombinant monoclonal anti‐cocaine antibody, h2E2, sequesters cocaine in plasma increasing concentrations more than 10‐fold. The increased levels of cocaine in the plasma could have detrimental peripheral effects, particularly on th
Externí odkaz:
https://doaj.org/article/1332bff8bbba4c00b3ce6a61e075e4c3
Autor:
Jhanvi N. Desai, Abigail R. Muccilli, Luis E. Tron Esqueda, Jeffrey A. Welge, PhD, Andrew B. Norman, PhD
Publikováno v:
Current Therapeutic Research, Vol 99, Iss , Pp 100727- (2023)
ABSTRACT: Background: Many features of self-administration behavior may be explained by reference to the properties of schedules of reinforcement. Schedules alter the probability of a behavior being reinforced and thereby increase, or decrease, the f
Externí odkaz:
https://doaj.org/article/162c5cc4f70c4e7fab430f250cfb9cd5
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Transition from the highest rate of lever-pressing activity during the unloading (extinction) phase of a cocaine self-administration session to an extremely low activity rate during the remission phase is in many cases gradual. This makes it
Externí odkaz:
https://doaj.org/article/3784459f81b041a2bc35b55ebae92b38