Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Andrew P. Makrigiannis"'
Autor:
Brendon D. Parsons, Daniel Medina-Luna, Michal Scur, Marinella Pinelli, Gayani S. Gamage, Rebecca A. Chilvers, Yannick Hamon, Ibrahim H.I. Ahmed, Stéphane Savary, Andrew P. Makrigiannis, Nancy E. Braverman, Juan F. Rodriguez-Alcazar, Eicke Latz, Tobias K. Karakach, Francesca Di Cara
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113744- (2024)
Summary: Peroxisome biogenesis disorders (PBDs) represent a group of metabolic conditions that cause severe developmental defects. Peroxisomes are essential metabolic organelles, present in virtually every eukaryotic cell and mediating key processes
Externí odkaz:
https://doaj.org/article/a066126b3d614f75b0ca3c0d6ec4d610
Autor:
Raghd Al Olabi, Abd El Aziz Hendy, Mohamad Basem Alkassab, Karla Alnajm, Manahel Elias, Mary Ibrahim, James R. Carlyle, Andrew P. Makrigiannis, Mir Munir A Rahim
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTNatural killer (NK) cells are an important component of anti-cancer immunity, and their activity is regulated by an array of activating and inhibitory receptors. In mice, the inhibitory NKR-P1B receptor is expressed in NK cells and recognizes
Externí odkaz:
https://doaj.org/article/6acd1ed0413d4a638bc17330218a8f88
Autor:
Michal Scur, Ahmad Bakur Mahmoud, Sayanti Dey, Farah Abdalbarri, Iona Stylianides, Daniel Medina-Luna, Gayani S. Gamage, Aaron Woblistin, Alexa N. M. Wilson, Haggag S. Zein, Ashley Stueck, Andrew Wight, Oscar A. Aguilar, Francesca Di Cara, Brendon D. Parsons, Mir Munir A. Rahim, James R. Carlyle, Andrew P. Makrigiannis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Alveolar macrophages (AM) in the lungs maintain surfactant during homeostasis and respond to infectious pathogens. Here the authors show that in the absence of NKR-P1B, pneumococcal infection is more severe because KO AM have increased rates of lipid
Externí odkaz:
https://doaj.org/article/ca6a2921570140329609abd0d7a69abd
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Our understanding of the C-type lectin-like receptors (CTLRs) and their functions in immunity have continued to expand from their initial roles in pathogen recognition. There are now clear examples of CTLRs acting as scavenger receptors, sensors of c
Externí odkaz:
https://doaj.org/article/09945eee95c44153864c0d61ea51df9b
Autor:
Haggag S. Zein, Elias Abou-Samra, Michal Scur, Alex Gutsol, Clayton W. Hall, Bishal Dasgupta, Lara Gharibeh, Turki Abujamel, Daniel Medina-Luna, Gayani S. Gamage, Tessa J. Pelino, Mona Nemer, Mir Munir A. Rahim, Alexander Steinle, Brendon D. Parsons, Andrew P. Makrigiannis
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract The C-type lectin-related protein, Clr-f, encoded by Clec2h in the mouse NK gene complex (NKC), is a member of a family of immune regulatory lectins that guide immune responses at distinct tissues of the body. Clr-f is highly expressed in th
Externí odkaz:
https://doaj.org/article/def7019997cf41cd84054dbbb63b9616
Autor:
Rebecca C. Auer, John C. Bell, David F. Stojdl, E. Celia Marginean, Blair Macdonald, Greg O. Cron, Andrew P. Makrigiannis, Ahmad Bakur Mahmoud, Abhirami A. Ananth, Shalini Sahi, Charles Lefebvre, Jiqing Zhang, Christiano Tanese de Souza, Michael A. Kennedy, Lee-Hwa Tai, Almohanad A. Alkayyal
Sequences of IL12 conjoined regions of MG1-IL12 and G-less MRB-IL12 viruses.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c6526dce7f74410aea8fee4bb851e3e
https://doi.org/10.1158/2326-6066.22538819.v1
https://doi.org/10.1158/2326-6066.22538819.v1
Autor:
Rebecca C. Auer, John C. Bell, David F. Stojdl, E. Celia Marginean, Blair Macdonald, Greg O. Cron, Andrew P. Makrigiannis, Ahmad Bakur Mahmoud, Abhirami A. Ananth, Shalini Sahi, Charles Lefebvre, Jiqing Zhang, Christiano Tanese de Souza, Michael A. Kennedy, Lee-Hwa Tai, Almohanad A. Alkayyal
Supplementary figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1c71604e02be090292e90c4d3e38073
https://doi.org/10.1158/2326-6066.22538798
https://doi.org/10.1158/2326-6066.22538798
Ly49 receptors, which recognize “self” class I major histocompatibility complex (MHC-I) molecules, enable natural killer (NK) cells to detect loss of MHC-I expression on transformed and virally infected cells. The impact of NK cell–mediated MHC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2867eca53f100c5a0075a8b600437ab
https://doi.org/10.1158/2326-6066.c.6548134.v1
https://doi.org/10.1158/2326-6066.c.6548134.v1
Autor:
Rebecca C. Auer, John C. Bell, David F. Stojdl, E. Celia Marginean, Blair Macdonald, Greg O. Cron, Andrew P. Makrigiannis, Ahmad Bakur Mahmoud, Abhirami A. Ananth, Shalini Sahi, Charles Lefebvre, Jiqing Zhang, Christiano Tanese de Souza, Michael A. Kennedy, Lee-Hwa Tai, Almohanad A. Alkayyal
Despite improvements in chemotherapy and radical surgical debulking, peritoneal carcinomatosis (PC) remains among the most common causes of death from abdominal cancers. Immunotherapies have been effective for selected solid malignancies, but their p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66212810c1ebef502b2444aa8579d15b
https://doi.org/10.1158/2326-6066.c.6548900
https://doi.org/10.1158/2326-6066.c.6548900
Supp 1. Analysis of tumor-infiltrating lymphocytes in E0771-induced mammary tumors. Supp 2. Splenocytes from tumor-bearing MMTV-PyVTTg mice are not activated. Supp 3. Analysis of tumor-infiltrating lymphocytes in mammary tumors from MMTV-14 PyVTTg mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fa02c211677040ceba7a763d82e0eaf
https://doi.org/10.1158/2326-6066.22536388
https://doi.org/10.1158/2326-6066.22536388