Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Andrew P. Kurland"'
Autor:
Christina A. Higgins, Benjamin E. Nilsson-Payant, Boris Bonaventure, Andrew P. Kurland, Chengjin Ye, Tomer M. Yaron, Jared L. Johnson, Prithy Adhikary, Ilona Golynker, Maryline Panis, Oded Danziger, Brad R. Rosenberg, Lewis C. Cantley, Luis Martínez-Sobrido, Benjamin tenOever, Jeffrey R. Johnson
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus disease 2019 (COVID-19) pandemic, drastically modifies infected cells to optimize virus replication. One such modification is the activation
Externí odkaz:
https://doaj.org/article/f4d8484e81a64893a39af20ce68f7785
Publikováno v:
Viruses, Vol 15, Iss 5, p 1112 (2023)
Innate immune pathways are tightly regulated to balance an appropriate response to infectious agents and tolerable levels of inflammation. Dysregulation of innate immune pathways can lead to severe autoinflammatory disorders or susceptibility to infe
Externí odkaz:
https://doaj.org/article/d92b6bbd0d594f6590e2aeaa2c331008
Publikováno v:
Journal of Virology. 97
Here, we demonstrate that a family of proteins from archaea specifically inhibit this splicing biology of all tested members of the Orthomyxoviridae family. We show that this inhibition extends to influenza A virus, influenza B virus, and isavirus ge
Autor:
Alex K. Lam, Romin Roshan, Wendell Miley, Nazzarena Labo, James Zhen, Andrew P. Kurland, Celine Cheng, Haigen Huang, Pu-Lin Teng, Claire Harelson, Danyang Gong, Ying K. Tam, Caius G. Radu, Marta Epeldegui, Jeffrey R. Johnson, Z. Hong Zhou, Denise Whitby, Ting-Ting Wu
Publikováno v:
Journal of virology, vol 97, iss 2
Infection by Kaposi sarcoma-associated herpesvirus (KSHV) can cause severe consequences, such as cancers and lymphoproliferative diseases. Whole inactivated viruses (WIV) with chemically destroyed genetic materials have been used as antigens in sever
Autor:
Joshua A Acklin, Aum R Patel, Shu Horiuchi, Arianna S Moss, Andrew P Kurland, Patricia Thibault, Emma J Degrace, Satoshi Ikegame, Jillian Carmichael, Naoko Imai, Hideki Ueno, Benjamin Tweel, Jeffrey R Johnson, Brad R Rosenberg, Benhur Lee, Jean K Lim
Lymph nodes are the primary site of replication for measles virus (MeV). Here, we modeled MeV infection in human tonsil explants, utilizing a clinical strain of MeV that expresses GFP. We show that MeV replicates efficiently in this tissue as measure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b0533636f96bd4118d3ef2abb311dd4
https://doi.org/10.1101/2022.09.12.507535
https://doi.org/10.1101/2022.09.12.507535
Autor:
Jeffrey R. Johnson, David C. Crosby, Judd F. Hultquist, Andrew P. Kurland, Prithy Adhikary, Donna Li, John Marlett, Justine Swann, Ruth Hüttenhain, Erik Verschueren, Tasha L. Johnson, Billy W. Newton, Michael Shales, Viviana A. Simon, Pedro Beltrao, Alan D. Frankel, Alexander Marson, Jeffery S. Cox, Oliver I. Fregoso, John A.T. Young, Nevan J. Krogan
Publikováno v:
Cell reports, vol 39, iss 2
Cell Reports, 39 (2)
Cell Reports, 39 (2)
Viruses must effectively remodel host cellular pathways to replicate and evade immune defenses, and they must do so with limited genomic coding capacity. Targeting post-translational modification (PTM) pathways provides a mechanism by which viruses c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6761189536151f78dc8ad100c5fe511
Autor:
Christina A. Higgins, Benjamin E. Nilsson-Payant, Andrew P. Kurland, Chengjin Ye, Tomer Yaron, Jared L. Johnson, Boris Bonaventure, Prithy Adhikary, Ilona Golynker, Maryline Panis, Oded Danziger, Brad R. Rosenberg, Lewis C. Cantley, Luis Martinez-Sobrido, Benjamin R. tenOever, Jeffrey R. Johnson
SARS-CoV-2, the causative agent of the COVID-19 pandemic, drastically modifies infected cells in an effort to optimize virus replication. Included is the activation of the host p38 mitogen-activated protein kinase (MAPK) pathway, which plays a major
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf25b756c76ccfd4b75371b1616865cb
https://doi.org/10.1101/2021.08.20.457146
https://doi.org/10.1101/2021.08.20.457146
Autor:
Billy W. Newton, Michelle Trester-Zedlitz, Mark von Zastrow, Grace E. Peng, Nikoleta G. Tsvetanova, Jeffrey R. Johnson, Nevan J. Krogan, Andrew P. Kurland, David Jimenez-Morales
Publikováno v:
The Journal of Biological Chemistry
Endosomal signaling downstream of G-protein-coupled receptors (GPCRs) has emerged as a novel paradigm with important pharmacological and physiological implications. However, our knowledge of the functional consequences of intracellular signaling is i