Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Andrew P. J. Brunskill"'
Publikováno v:
Acta Crystallographica Section E, Vol 66, Iss 10, Pp o2576-o2577 (2010)
The asymmetric unit of the title compound, C8H12O3, consists of a single conformational enantiomer, which aggregates in the catemeric acid-to-ketone hydrogen-bonding mode [O...O = 2.682 (4) Å and O—H...O = 172 (6)°]. Four hydrogen-bonding chains
Externí odkaz:
https://doaj.org/article/179f4d094bc443ab8ab26099e388dd68
Publikováno v:
Acta Crystallographica Section E, Vol 64, Iss 9, Pp o1664-o1664 (2008)
The title keto acid, C16H18O3, displays significant twisting of all three ethylene bridges in its bicyclo[2.2.2]octane structure owing to steric interactions; the bridgehead-to-bridgehead torsion angles are 13.14 (12), 13.14 (13) and 9.37 (13)°. The
Externí odkaz:
https://doaj.org/article/7c6370cd70844ef5992e01fe8f5774fa
Autor:
Anthony J, Roecker, Mark E, Layton, Joseph E, Pero, Michael J, Kelly, Thomas J, Greshock, Richard L, Kraus, Yuxing, Li, Rebecca, Klein, Michelle, Clements, Christopher, Daley, Aneta, Jovanovska, Jeanine E, Ballard, Deping, Wang, Fuqiang, Zhao, Andrew P J, Brunskill, Xuanjia, Peng, Xiu, Wang, Haiyan, Sun, Andrea K, Houghton, Christopher S, Burgey
Publikováno v:
ACS Med Chem Lett
[Image: see text] The voltage-gated sodium channel Na(v)1.7 continues to be a high-profile target for the treatment of various pain afflictions due to its strong human genetic validation. While isoform selective molecules have been discovered and adv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::72b379a09d4cd36535ea9e98211ef1a7
https://pubmed.ncbi.nlm.nih.gov/34141090
https://pubmed.ncbi.nlm.nih.gov/34141090
Autor:
Nathan D, Rudd, Mikhail, Reibarkh, Rui, Fang, Sachin, Mittal, Paul L, Walsh, Andrew P J, Brunskill, William P, Forrest
Publikováno v:
Molecular pharmaceutics. 17(5)
Injectable sustained release dosage forms have emerged as desirable therapeutic routes for patients that require life-long treatments. The prevalence of drug molecules with low aqueous solubility and bioavailability has added momentum toward the deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::31dcf1deed2949b40afaaae6c32074f2
https://pubmed.ncbi.nlm.nih.gov/32267708
https://pubmed.ncbi.nlm.nih.gov/32267708
Autor:
Louis-Charles Campeau, Andrew P. J. Brunskill, Cheol K. Chung, Michael Williams, Mark McLaughlin, Jongrock Kong
Publikováno v:
ChemInform. 47
Olefin metathesis (OM) is a reliable and practical synthetic methodology for challenging carbon–carbon bond formations. While existing catalysts can effect many of these transformations, the synthesis and development of new catalysts is essential t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b07c46b5f785e22501701d53c2cb427a
https://doi.org/10.1002/chin.201636048
https://doi.org/10.1002/chin.201636048
Autor:
Andrew P. J. Brunskill, Mark McLaughlin, Louis-Charles Campeau, Cheol K. Chung, Michael Williams, Jongrock Kong
Publikováno v:
Organic letters. 18(9)
Olefin metathesis (OM) is a reliable and practical synthetic methodology for challenging carbon–carbon bond formations. While existing catalysts can effect many of these transformations, the synthesis and development of new catalysts is essential t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2dda36ec1db61cdae7a11a4ebf43f06
https://pubmed.ncbi.nlm.nih.gov/27123552
https://pubmed.ncbi.nlm.nih.gov/27123552
Publikováno v:
Journal of Organometallic Chemistry. 690:2272-2277
The synthesis, characterization and X-ray crystal structure of 1,1-(rac-1,1′-bi-2-naphthoxy)-1-silacyclobutane (1) are reported and reveal an unusual planar conformation with a Si-βC distance of 2.302 (5) A. Reaction of 1 with either stoichiometri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e92e9ad11e394196d95bba01112ccbfa
https://doi.org/10.1016/j.jorganchem.2005.02.032
https://doi.org/10.1016/j.jorganchem.2005.02.032
Autor:
Andrew P. J. Brunskill
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 73:a73-a73
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7e1482d293c18f80a3665f8df77fa9a
https://doi.org/10.1107/s0108767317099275
https://doi.org/10.1107/s0108767317099275
Publikováno v:
Acta Crystallographica Section C Crystal Structure Communications. 55:1899-1902
The title keto acid, (+)-trans-3-acetyl-2,2-dimethylcyclobutanecarboxylic acid, C 9 H 14 O 3 , derived from (-)-verbenone, aggregates in the solid as helical acid-to-ketone hydrogen-bonding chains extending in the b-cell direction [O...O = 2.711 (3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ebf58f7dbd804f7a85bd86b0ede2782
https://doi.org/10.1107/s0108270199010380
https://doi.org/10.1107/s0108270199010380
Publikováno v:
Acta Crystallographica Section C Crystal Structure Communications. 55:1905-1908
Both the di-endo, (I), and the 2-endo-3-exo, (II), diastereomers of the title keto acid (C 15 H 16 O 3 ) crystallize as centrosymmetric carboxyl dimers, whose hydrogen bonding does not involve the ketone function [(I) O…O = 2.635 (3), (II) O…O =
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f896a6c8ec0d7c967bbdf45c11955de
https://doi.org/10.1107/s0108270199009245
https://doi.org/10.1107/s0108270199009245