Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Andrew P. Craven"'
Autor:
Peter R. Butchers, Victoria J. Barrett, Peter J. Mutch, Andrew P. Craven, Sara C Hughes, Mark Ruston, Duncan S. Holmes, Alison J. Ford, Keith Biggadike, Brian Edgar Looker, Stephen Barry Guntrip, Anne Jones, Deborah Needham, Panayiotis A. Procopiou, Claire E. Smith
Publikováno v:
Journal of medicinal chemistry. 57(1)
A series of novel, potent, and selective human β2 adrenoceptor agonists incorporating a sulfone moiety on the terminal right-hand-side phenyl ring of (R)-salmeterol is presented. Sulfone 10b had salmeterol-like potency and selectivity profile, long
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50b6472cee081248047681c7f3def8d6
https://pubmed.ncbi.nlm.nih.gov/24359185
https://pubmed.ncbi.nlm.nih.gov/24359185
Autor:
Diane M. Coe, Vipulkumar Kantibhai Patel, Stephen Swanson, Ian B. Campbell, Simon J. F. Macdonald, John Liddle, Gail Fisher, M. Jonathan Fray, Ian Churcher, Graham G. A. Inglis, Ian Robert Baldwin, Natalie Wellaway, Anthony William James Cooper, Henry Anderson Kelly, Nick Barton, Jack A. Brown, Aoife C. Maxwell, Andrew P. Craven
Publikováno v:
Drug discovery today. 18(23-24)
A practical drug discovery project for third-year undergraduates is described. No previous knowledge of medicinal chemistry is assumed. Initial lecture-workshops cover the basic principles; then students are asked to improve the profile of a weakly p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4edeff8d4ce53c8b6519111517c50abe
https://pubmed.ncbi.nlm.nih.gov/24051399
https://pubmed.ncbi.nlm.nih.gov/24051399
Autor:
Nigel Stephen Stevenage Watson, Champa Patel, Steven John Coote, Henry Anderson Stevenage Kelly, Neil Anthony Pegg, Andrew Lowdon, William Leonard Mitchell, Rhian Thomas, Pamela J Thomas, Edward McDonald, Sean Hindley, Andrew Baxter, Martin Pass, Chi-Man Tang, Andrew P Craven, Harry Finch, Dawn A Walker, Christopher J. Mooney, Said Abu-Rabie, Harren Jhoti, Simon Parry, Pan A. Procopiou, Richard Conroy, Nigel G Ramsden
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(12)
A series of trans-fused lactams containing the indane nucleus has been prepared. Compound 19 has much enhanced plasma stability compared with its lactone counterpart and shows appreciable in vitro anticoagulant activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84d3e00bc5795729c712e852bf8850d0
https://pubmed.ncbi.nlm.nih.gov/10397495
https://pubmed.ncbi.nlm.nih.gov/10397495
Publikováno v:
Tetrahedron. 45:2417-2429
On heating a dilute solution of a 2 : 1 mixture of the (8' E )- and (8' Z )-3-(1-oxotrienyl)-Δ3-pyrrolin-2-ones (36), Diels Alder cyclization occurred. The minor (8'Z)-pyrrolinone cyclized stereoselectively to give the endo adduct (39) which has the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ba961ced0e858a601f0ca59bb671d74
https://doi.org/10.1016/s0040-4020(01)83439-6
https://doi.org/10.1016/s0040-4020(01)83439-6
Publikováno v:
J. Chem. Soc., Chem. Commun.. :145-147
As preparation for a proposed synthesis of cytochalasin D, the triene-pyrrolinone (12) was shown to cyclize stereoselectively on heating (12h, 100 °C) in toluene to give the Diels–Alder product (13)(40–45%), and a synthesis of the protected dihy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86cfd22e3f96f9c0e6e9b2b0ca4fdf0f
https://doi.org/10.1039/c39850000145
https://doi.org/10.1039/c39850000145
Publikováno v:
ChemInform. 20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9997a0e7b3ae0aae00c004f3bea0bec
https://doi.org/10.1002/chin.198933336
https://doi.org/10.1002/chin.198933336
Publikováno v:
Chemischer Informationsdienst. 16
Auf dem im Formelschema beschriebenen Weg entsteht die Verbindung (VII), die das Ringgerust von Cytochalasin D (VIII) besitzt.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68c532a62473c54ed230998e9f163428
https://doi.org/10.1002/chin.198524358
https://doi.org/10.1002/chin.198524358