Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Andrew P. Combs"'
Autor:
Jun Li, Margaret Favata, Jennifer A. Kelley, Eian Caulder, Beth Thomas, Xiaoming Wen, Richard B. Sparks, Ari Arvanitis, James D. Rogers, Andrew P. Combs, Kris Vaddi, Kimberly A. Solomon, Peggy A. Scherle, Robert Newton, Jordan S. Fridman
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 12, Iss 1, Pp 28-38 (2010)
Cytokines in the bone marrow of multiple myeloma patients activate Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathways in tumor cells and promote tumor growth, survival, and drug resistance. INCB16562 was dev
Externí odkaz:
https://doaj.org/article/8ff70b38f3cd4dcba837d81f78e72017
Autor:
Andrew J. Combs
Publikováno v:
International Brazilian Journal of Urology, Vol 47, Iss 5, Pp 979-981 (2021)
Externí odkaz:
https://doaj.org/article/98aa14a6447645b8b171feb371879f12
Autor:
Phillip C.C. Liu, Peggy Scherle, Gregory Hollis, Reid Huber, Andrew P. Combs, Wenqing Yao, Chu-Biao Xue, Swamy Yeleswaram, Bruce Ruggeri, Richard Wynn, Maryanne Covington, Yanlong Li, Xin He, Christine Gardiner, Pramod Thekkat, Valerie Dostalik, Patricia Feldman, Darlise DiMatteo, Padmaja Polam, Nikoo Falahatpisheh, Robert Collins, Jun Li, Xuesong Mike Liu, Huiqing Liu, Ravi Jalluri, Margaret Favata, Paul Waeltz, Nina Zolotarjova, Alla Volgina, Xiaoming Wen, Mark Rupar, Sharon Diamond, Thomas Maduskuie, Richard Sparks, Timothy C. Burn, Matthew C. Stubbs
Supplemental Tables 1 & 2 Supplemental Figure Legends Supplemental Figures 1 - 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a9cd1caeb5c5e06cfd8b05f86b576b1
https://doi.org/10.1158/1078-0432.22475952
https://doi.org/10.1158/1078-0432.22475952
Autor:
Phillip C.C. Liu, Peggy Scherle, Gregory Hollis, Reid Huber, Andrew P. Combs, Wenqing Yao, Chu-Biao Xue, Swamy Yeleswaram, Bruce Ruggeri, Richard Wynn, Maryanne Covington, Yanlong Li, Xin He, Christine Gardiner, Pramod Thekkat, Valerie Dostalik, Patricia Feldman, Darlise DiMatteo, Padmaja Polam, Nikoo Falahatpisheh, Robert Collins, Jun Li, Xuesong Mike Liu, Huiqing Liu, Ravi Jalluri, Margaret Favata, Paul Waeltz, Nina Zolotarjova, Alla Volgina, Xiaoming Wen, Mark Rupar, Sharon Diamond, Thomas Maduskuie, Richard Sparks, Timothy C. Burn, Matthew C. Stubbs
Purpose:Bromodomain and extraterminal domain (BET) proteins regulate the expression of many cancer-associated genes and pathways; BET inhibitors have demonstrated activity in diverse models of hematologic and solid tumors. We report the preclinical c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67622e0fbfefceb9ea9cf87738b999fe
https://doi.org/10.1158/1078-0432.c.6529230.v1
https://doi.org/10.1158/1078-0432.c.6529230.v1
Autor:
Jordan S. Fridman, Kris Vaddi, Timothy C. Burn, James D. Rodgers, Andrew P. Combs, Richard B. Sparks, Patrick Haley, Gregory Hollis, Erin Crowgey, Yanlong Li, Mary Becker-Pasha, Richard Wynn, Alex Margulis, Paul Waeltz, Jun Li, Eian Caulder, Phillip C.C. Liu
Supplementary Data from Combined Inhibition of Janus Kinase 1/2 for the Treatment of JAK2V617F-Driven Neoplasms: Selective Effects on Mutant Cells and Improvements in Measures of Disease Severity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e47b931a262ce765e455bcf760d62f8
https://doi.org/10.1158/1078-0432.22440651
https://doi.org/10.1158/1078-0432.22440651
Publikováno v:
Burger's Medicinal Chemistry and Drug Discovery. :1-30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a6001ef36ebd053ba01c5b3930f885d
https://doi.org/10.1002/0471266949.bmc272
https://doi.org/10.1002/0471266949.bmc272
Autor:
Qian Wang, Sybil O'Connor, Alan Roberts, Brian W. Metcalf, Leslie Hall, Maxim Soloviev, Michael Hansbury, Greg Hollis, Xin He, Matthew C. Stubbs, Niu Shin, Wenqing Yao, Kamna Katiyar, Phillip C.C. Liu, Kathy Wang, Sharon Diamond, Brent Douty, Gengjie Yang, Dana Shuey, Maryanne B. Covington, Paul Collier, Mingming Gao, Patricia Feldman, Peggy Scherle, Timothy Burn, Andrew P. Combs, Yun-Long Li, Lynn Leffet, Robert C. Newton, Paul Waeltz, Holly Koblish, Jin Lu, Swamy Yeleswaram, Yanlong Li, Reid Huber, Robert Collins, Eddy W. Yue
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 374:211-222
The clinical use of first-generation phosphoinositide 3-kinase (PI3K)δ inhibitors in B-cell malignancies is hampered by hepatotoxicity, requiring dose reduction, treatment interruption, and/or discontinuation of therapy. In addition, potential molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::450ddea425cecfdf40bf1184c7e8c723
https://doi.org/10.1124/jpet.120.265538
https://doi.org/10.1124/jpet.120.265538
Autor:
Reid Huber, Maryanne Covington, Xin He, Paul Waeltz, Valerie Dostalik, Yanlong Li, Nina Zolotarjova, Chu-Biao Xue, Matthew C. Stubbs, Jun Li, Huiqing Liu, Peggy Scherle, Timothy Burn, Sharon Diamond, Thomas Maduskuie, Wenqing Yao, Padmaja Polam, Richard B. Sparks, Christine Gardiner, Xuesong Mike Liu, Robert Collins, Nikoo Falahatpisheh, Andrew P. Combs, Phillip Liu, Margaret Favata, Gregory Hollis, Richard Wynn, Swamy Yeleswaram, Bruce Ruggeri, Alla Volgina, Ravi Kumar Jalluri, Pramod Thekkat, Darlise DiMatteo, Patricia Feldman, Mark Rupar, Xiaoming Wen
Publikováno v:
Clinical Cancer Research. 25:300-311
Purpose: Bromodomain and extraterminal domain (BET) proteins regulate the expression of many cancer-associated genes and pathways; BET inhibitors have demonstrated activity in diverse models of hematologic and solid tumors. We report the preclinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd0f9e6b013bb2a593a4e013aa8feee1
https://doi.org/10.1158/1078-0432.ccr-18-0098
https://doi.org/10.1158/1078-0432.ccr-18-0098
Autor:
Andrew P Combs, Niu Shin, Laurine Galya, James Hall, Sharon Diamond, Kevin Baptiste, Jason Boer, Yan-ou Yang, Kevin J Bowman, Maryanne B Covington, Yanlong Li, Xin He, Daniel Levy, Brent D Douty, Padmaja Polam, David M Burns, Artem Shvartsbart, Eddy W Yue, Rick Sparks, Nikoo Falahatpisheh, Lixin Shao, Stacey Shepard, Andrew W Buesking
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d9b46276e455cc32362364091e1119
https://doi.org/10.1021/scimeetings.0c06483
https://doi.org/10.1021/scimeetings.0c06483
Autor:
Kris Vaddi, Alexander Grego, William Gowen-MacDonald, Neha Bhagwat, Xiaowei Wu, Jincong Zhuo, Peggy Scherle, Bruce Ruggeri, Miles Cowart, Andrew P. Combs, Min Wang
Publikováno v:
Cancer Research. 81:983-983
MCL1 is a member of the anti-apoptotic BCL2 family of proteins and plays a critical role in maintaining cellular homeostasis and promoting cell survival. It is frequently amplified in cancer and increased expression of MCL1 is associated with a highe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e7a3926343414f1437ae8c4873c1e54
https://doi.org/10.1158/1538-7445.am2021-983
https://doi.org/10.1158/1538-7445.am2021-983