Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Andrew P. Capaldi"'
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Yeast cells respond to nutrients by altering expression of the protein synthesis genes and thus their growth rate. Here, the authors use microarrays to show that TORC1 controls gene expression during steady state growth while PKA speeds up expression
Externí odkaz:
https://doaj.org/article/c2f0f6643f4a4866a44a494c9713d2d7
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 2, Pp 463-474 (2016)
The Target of Rapamycin kinase Complex I (TORC1) is a master regulator of cell growth and metabolism in eukaryotes. Studies in yeast and human cells have shown that nitrogen/amino acid starvation signals act through Npr2/Npr3 and the small GTPases Gt
Externí odkaz:
https://doaj.org/article/13c67a4a95d44f259888d57ff3390410
Publikováno v:
Cell Reports, Vol 3, Iss 5, Pp 1476-1482 (2013)
Cells respond to stress and starvation by adjusting their growth rate and enacting stress defense programs. In eukaryotes this involves inactivation of TORC1, which in turn triggers downregulation of ribosome and protein synthesis genes and upregulat
Externí odkaz:
https://doaj.org/article/6402d499f9654e6d8350e88769089bfa
Eukaryotic cells create gradients of cAMP across space and time to regulate the cAMP dependent protein kinase (PKA) and, in turn, growth and metabolism. However, how PKA responds to different concentrations of cAMP is unclear. Here, to address this q
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b135584a8bcc577fbc43ebb3d1d6bf6
https://doi.org/10.1101/2022.03.10.483795
https://doi.org/10.1101/2022.03.10.483795
Autor:
Adam C. Resnick, Andrew P. Capaldi, Victoria A. Morrissette, Ronda J. Rolfes, Elizabeth A. Steidle, Lucy Chong, Kotaro Fujimaki
Publikováno v:
Journal of Biological Chemistry. 295:2043-2056
The environmental stress response (ESR) is critical for cell survival. Yeast cells unable to synthesize inositol pyrophosphates (PP-InsPs) are unable to induce the ESR. We recently discovered a diphosphoinositol pentakisphosphate (PP-InsP5) phosphata
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4a393b0c43fc9196dd85444ba7f19ca
https://doi.org/10.1074/jbc.ra119.012148
https://doi.org/10.1074/jbc.ra119.012148
Publikováno v:
eLife, Vol 4 (2015)
The target of rapamycin complex I (TORC1) regulates cell growth and metabolism in eukaryotes. Previous studies have shown that nitrogen and amino acid signals activate TORC1 via the small GTPases, Gtr1/2. However, little is known about the way that o
Externí odkaz:
https://doaj.org/article/566b3174ac4b4a6ab0c4ec3eecfbbf0f
Publikováno v:
RNA
Assessing variations in mRNA stability typically involves inhibiting transcription either globally or in a gene-specific manner. Alternatively, mRNA pulse-labeling strategies offer a means to calculate mRNA stability without inhibiting transcription.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f91be357a133b86fb0284d16686159b1
https://doi.org/10.1261/rna.072892.119
https://doi.org/10.1261/rna.072892.119
Publikováno v:
Molecular Biology of the Cell
The target of rapamycin kinase complex 1 (TORC1) regulates cell growth and metabolism in eukaryotes. In Saccharomyces cerevisiae, TORC1 activity is known to be controlled by the conserved GTPases, Gtr1/2, and movement into and out of an inactive aggl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df7481d16b7aec7a79d0752bd2c7f509
http://europepmc.org/articles/PMC6589571
http://europepmc.org/articles/PMC6589571
Publikováno v:
eLife. 11
The target of rapamycin complex I (TORC1) regulates cell growth and metabolism in eukaryotes. Previous studies have shown that nitrogen and amino acid signals activate TORC1 via the highly conserved small GTPases, Gtr1/2 (RagA/C in humans), and the G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32cb80bf9294dcbfec6597c49e02bea2
https://pubmed.ncbi.nlm.nih.gov/36047762
https://pubmed.ncbi.nlm.nih.gov/36047762