Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Andrew P. Badrock"'
Autor:
Sarah E. Withers, Charlie F. Rowlands, Victor S. Tapia, Frances Hedley, Ioana-Emilia Mosneag, Siobhan Crilly, Gillian I. Rice, Andrew P. Badrock, Andrew Hayes, Stuart M. Allan, Tracy A. Briggs, Paul R. Kasher
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Aicardi-Goutières syndrome (AGS1-9) is a genetically determined encephalopathy that falls under the type I interferonopathy disease class, characterized by excessive type I interferon (IFN-I) activity, coupled with upregulation of IFN-stimulated gen
Externí odkaz:
https://doaj.org/article/21996985323c40e7b3c222331fcef159
Autor:
Berta Casar, Andrew P. Badrock, Iñaki Jiménez, Imanol Arozarena, Paula Colón-Bolea, L. Francisco Lorenzo-Martín, Irene Barinaga-Rementería, Jorge Barriuso, Vincenzo Cappitelli, Daniel J. Donoghue, Xosé R. Bustelo, Adam Hurlstone, Piero Crespo
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
RAS isoforms are associated with the plasma membrane and endomembranes, but how their localization contributes to tumorigenesis is unclear. Here, the authors show that RAS signals from Golgi complex antagonize tumour formation by inducing apoptosis v
Externí odkaz:
https://doaj.org/article/1f3887098b28416d9c9f3a9d72788b25
Autor:
Maria-Cristina Keightley, Duncan P. Carradice, Judith E. Layton, Luke Pase, Julien Y. Bertrand, Johannes G. Wittig, Aleksandar Dakic, Andrew P. Badrock, Nicholas J. Cole, David Traver, Stephen L. Nutt, Julia McCoey, Ashley M. Buckle, Joan K. Heath, Graham J. Lieschke
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Neutrophils are increased in response to injury and infection but how they form from a common granulocyte-macrophage progenitor is unclear. Here, the authors identify a role for the transcriptional repressor ZBTB11 in zebrafish, which is regulated by
Externí odkaz:
https://doaj.org/article/3c95ab3a3ca641e6961f1263d836b9c2
Autor:
Siobhan Crilly, Alexandra Njegic, Sarah E. Laurie, Elisavet Fotiou, Georgina Hudson, Jack Barrington, Kirsty Webb, Helen L. Young, Andrew P. Badrock, Adam Hurlstone, Jack Rivers-Auty, Adrian R. Parry-Jones, Stuart M. Allan, Paul R. Kasher
Publikováno v:
F1000Research, Vol 7 (2018)
Intracerebral haemorrhage (ICH) is a devastating condition with limited treatment options, and current understanding of pathophysiology is incomplete. Spontaneous cerebral bleeding is a characteristic of the human condition that has proven difficult
Externí odkaz:
https://doaj.org/article/4ae87017fdee48b597a54b019f099a8b
Autor:
Emily K. Don, Tanya A. de Jong-Curtain, Karen Doggett, Thomas E. Hall, Benjamin Heng, Andrew P. Badrock, Claire Winnick, Garth A. Nicholson, Gilles J. Guillemin, Peter D. Currie, Daniel Hesselson, Joan K. Heath, Nicholas J. Cole
Publikováno v:
Biology Open, Vol 5, Iss 3, Pp 359-366 (2016)
Here we genetically characterise pelvic finless, a naturally occurring model of hindlimb loss in zebrafish that lacks pelvic fin structures, which are homologous to tetrapod hindlimbs, but displays no other abnormalities. Using a hybrid positional cl
Externí odkaz:
https://doaj.org/article/d83ac8d9ad514894a1c433251cfa8b7d
Autor:
Adam Hurlstone, Adam W. McMahon, Kaye J. Williams, Emmanuelle Claude, Paul Lorigan, Michael P. Smith, Herman P. Spaink, Warwick B. Dunn, Katherine Hollywood, B. Ewa Snaar-Jagalska, Shuning He, Irene Barinaga-Rementeria Ramirez, Michael Fairclough, Michael Green, Jivko Kamarashev, Christos Evangelou, Raghavendar T. Nagaraju, Duncan Forster, Emrys A. Jones, Andrew P. Badrock, Hannah R. Johnston, Fiona Henderson
Figures S1-S9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697f43edb2bf6bdc192bdb9815714f7c
https://doi.org/10.1158/0008-5472.22423302.v1
https://doi.org/10.1158/0008-5472.22423302.v1
Autor:
Adam Hurlstone, Adam W. McMahon, Kaye J. Williams, Emmanuelle Claude, Paul Lorigan, Michael P. Smith, Herman P. Spaink, Warwick B. Dunn, Katherine Hollywood, B. Ewa Snaar-Jagalska, Shuning He, Irene Barinaga-Rementeria Ramirez, Michael Fairclough, Michael Green, Jivko Kamarashev, Christos Evangelou, Raghavendar T. Nagaraju, Duncan Forster, Emrys A. Jones, Andrew P. Badrock, Hannah R. Johnston, Fiona Henderson
From microarray analysis, genes from VGP melanocyte neoplasia whose transcripts are significantly up- or down-regulated compared to wild-type tissue that are associated with lipid metabolism and are not differentially expressed also in BRAFV600E or V
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::416afdf3625885198b3a68172e8da154
https://doi.org/10.1158/0008-5472.22423296.v1
https://doi.org/10.1158/0008-5472.22423296.v1
Autor:
Adam Hurlstone, Adam W. McMahon, Kaye J. Williams, Emmanuelle Claude, Paul Lorigan, Michael P. Smith, Herman P. Spaink, Warwick B. Dunn, Katherine Hollywood, B. Ewa Snaar-Jagalska, Shuning He, Irene Barinaga-Rementeria Ramirez, Michael Fairclough, Michael Green, Jivko Kamarashev, Christos Evangelou, Raghavendar T. Nagaraju, Duncan Forster, Emrys A. Jones, Andrew P. Badrock, Hannah R. Johnston, Fiona Henderson
Alterations in lipid metabolism in cancer cells impact cell structure, signaling, and energy metabolism, making lipid metabolism a potential diagnostic marker and therapeutic target. In this study, we combined PET, desorption electrospray ionization-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ef019f98143a99dcfe4bbad4adf2eb2
https://doi.org/10.1158/0008-5472.c.6511461.v1
https://doi.org/10.1158/0008-5472.c.6511461.v1
Autor:
Marta M. Gabryelska, Andrew P. Badrock, Jian You Lau, Raymond T. O'Keefe, Yanick J. Crow, Grzegorz Kudla
Publikováno v:
Gabryelska, M M, Badrock, A P, Lau, J Y, O'Keefe, R T, Crow, Y J & Kudla, G 2022, ' Global mapping of RNA homodimers in living cells ', Genome Research, vol. 32, pp. 956-967 . https://doi.org/10.1101/gr.275900.121
RNA homodimerization is important for various physiological processes, including the assembly of membraneless organelles, RNA subcellular localization, and packaging of viral genomes. However, understanding RNA dimerization has been hampered by the l
Autor:
Thomas E. Hall, Roger S. Chung, Emily K. Don, Nicholas J. Cole, Andres Vidal-Itriago, Alina Maschirow, Angela S. Laird, Andrew P. Badrock, Albert Lee, Isabel Formella, Marco Morsch, Cindy Maurel, Jack J Stoddart, Bingyang Shi, Natalie M. Scherer, Rowan A. W. Radford, Alison L. Hogan
Publikováno v:
Molecular Neurobiology
Amyotrophic lateral sclerosis (ALS) is a form of motor neuron disease (MND) that is characterized by the progressive loss of motor neurons within the spinal cord, brainstem and motor cortex. Although ALS clinically manifests as a heterogeneous diseas