Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Andrew P Wojtovich"'
Autor:
Andrew P Wojtovich, Teresa A Sherman, Sergiy M Nadtochiy, William R Urciuoli, Paul S Brookes, Keith Nehrke
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28287 (2011)
Mitochondrial potassium channels are important mediators of cell protection against stress. The mitochondrial large-conductance "big" K(+) channel (mBK) mediates the evolutionarily-conserved process of anesthetic preconditioning (APC), wherein exposu
Externí odkaz:
https://doaj.org/article/df446d12a17047628ab10422eff63521
Autor:
Shon A. Koren, Nada Ahmed Selim, Lizbeth De la Rosa, Jacob Horn, M. Arsalan Farooqi, Alicia Y. Wei, Annika Müller-Eigner, Jacen Emerson, Gail V. W. Johnson, Andrew P. Wojtovich
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Hydrogen peroxide (H2O2) functions as a second messenger to signal metabolic distress through highly compartmentalized production in mitochondria. The dynamics of reactive oxygen species (ROS) generation and diffusion between mitochondrial c
Externí odkaz:
https://doaj.org/article/7b0033df46a044cb9db30385396d9e8c
Publikováno v:
Redox Biology, Vol 67, Iss , Pp 102934- (2023)
Environmental surveillance-mediated behavior integrates multiple cues through complex signaling mechanisms. In Caenorhabditis elegans, neurons coordinate perception and response through evolutionarily conserved molecular signaling cascades to mediate
Externí odkaz:
https://doaj.org/article/a017bbc0752f465c999dd47a9a4460f4
Publikováno v:
Redox Biology, Vol 67, Iss , Pp 102926- (2023)
Mitochondria are a main source of cellular energy. Oxidative phosphorylation (OXPHOS) is the major process of aerobic respiration. Enzyme complexes of the electron transport chain (ETC) pump protons to generate a protonmotive force (Δp) that drives
Externí odkaz:
https://doaj.org/article/95b230af644744e0a7aab7343f989e78
Autor:
John O. Onukwufor, M. Arsalan Farooqi, Anežka Vodičková, Shon A. Koren, Aksana Baldzizhar, Brandon J. Berry, Gisela Beutner, George A. Porter, Vsevolod Belousov, Alan Grossfield, Andrew P. Wojtovich
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Mitochondria regulate diverse cellular signalling processes in addition to producing energy. Here, the authors show a mitochondrial redox switch that, when activated, helps nematode worms sense conditions of low environmental oxygen.
Externí odkaz:
https://doaj.org/article/0ca5eb3f762f416595118bd779d947f4
Autor:
Shon A. Koren, Nada Ahmed Selim, Lizbeth De la Rosa, Jacob Horn, M. Arsalan Farooqi, Alicia Y. Wei, Annika Müller-Eigner, Jacen Emerson, Gail V. W. Johnson, Andrew P. Wojtovich
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/263075eb71884d479691005c49450a12
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 8, Pp 2629-2635 (2019)
The introduction of exogenous genes in single-copy at precise genomic locations is a powerful tool that has been widely used in the model organism Caenorhabditis elegans. Here, we have streamlined the process by creating a rapid, cloning-free method
Externí odkaz:
https://doaj.org/article/51a69915ce684fae844d1e075fa8eccf
Autor:
Andrea M. Amitrano, Brandon J. Berry, Kihong Lim, Kyun-Do Kim, Richard E. Waugh, Andrew P. Wojtovich, Minsoo Kim
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Although cancer immunotherapy is effective against hematological malignancies, it is less effective against solid tumors due in part to significant metabolic challenges present in the tumor microenvironment (TME), where infiltrated CD8+ T cells face
Externí odkaz:
https://doaj.org/article/dad50700108d4c4d8c5f124a22a23e6a
Publikováno v:
Antioxidants, Vol 11, Iss 4, p 692 (2022)
Alzheimer’s disease (AD) is a devastating progressive neurodegenerative disease characterized by neuronal dysfunction, and decreased memory and cognitive function. Iron is critical for neuronal activity, neurotransmitter biosynthesis, and energy ho
Externí odkaz:
https://doaj.org/article/0a221a7d6d5349e18589389d0617efc8
Autor:
Brandon J. Berry, Anežka Vodičková, Annika Müller-Eigner, Chen Meng, Christina Ludwig, Matt Kaeberlein, Shahaf Peleg, Andrew P. Wojtovich
Publikováno v:
Nature Aging. 3:157-161
Despite longstanding scientific interest in the centrality of mitochondria to biological aging, directly controlling mitochondrial function to test causality has eluded researchers. We show that specifically boosting mitochondrial membrane potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d6400423ce039eca7019924b0b2ad5
https://doi.org/10.1038/s43587-022-00340-7
https://doi.org/10.1038/s43587-022-00340-7