Výsledky vyhledávání - "Andrew P Mazar"

Akademický článek

Prognostic Impact of Urokinase Plasminogen Activator Receptor Expression in Pancreatic Cancer: Malignant Versus Stromal Cells

Autor: Susanna WL de Geus, Victor M Baart, Martin C Boonstra, Peter JK Kuppen, Hendrica AJM Prevoo, Andrew P Mazar, Bert A Bonsing, Hans Morreau, Cornelis JH van de Velde, Alexander L Vahrmeijer, Cornelis FM Sier

Publikováno v: Biomarker Insights, Vol 12 (2017)

The urokinase plasminogen activator receptor (uPAR) has been proposed as a potential prognostic factor for various malignancies. The aim of this study is to assess the prognostic value of uPAR expression in neoplastic and stromal cells of patients wi

Externí odkaz: https://doaj.org/article/8b5a1f7bcfdf4a9b9f8d83e4fcfe6533

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Akademický článek

Identification of a new epitope in uPAR as a target for the cancer therapeutic monoclonal antibody ATN-658, a structural homolog of the uPAR binding integrin CD11b (αM).

Autor: Xiang Xu, Yuan Cai, Ying Wei, Fernando Donate, Jose Juarez, Graham Parry, Liqing Chen, Edward J Meehan, Richard W Ahn, Andrey Ugolkov, Oleksii Dubrovskyi, Thomas V O'Halloran, Mingdong Huang, Andrew P Mazar

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e85349 (2014)

The urokinase plasminogen activator receptor (uPAR) plays a role in tumor progression and has been proposed as a target for the treatment of cancer. We recently described the development of a novel humanized monoclonal antibody that targets uPAR and

Externí odkaz: https://doaj.org/article/0173507ab52c4bee81931476328e41db

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Akademický článek

Glycogen synthase kinase 3 activity enhances liver inflammation in MASH

Publikováno v: JHEP Reports, Vol 6, Iss 6, Pp 101073- (2024)

Background & Aims: Metabolic dysfunction-associated steatohepatitis (MASH) is characterized by excessive circulating toxic lipids, hepatic steatosis, and liver inflammation. Monocyte adhesion to liver sinusoidal endothelial cells (LSECs) and transend

Externí odkaz: https://doaj.org/article/140f68733e754e61917380b70dbef94e

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Akademický článek

Nano-encapsulation of arsenic trioxide enhances efficacy against murine lymphoma model while minimizing its impact on ovarian reserve in vitro and in vivo.

Autor: Richard W Ahn, Susan L Barrett, Meera R Raja, Jennifer K Jozefik, Lidia Spaho, Haimei Chen, Marcel B Bally, Andrew P Mazar, Michael J Avram, Jane N Winter, Leo I Gordon, Lonnie D Shea, Thomas V O'Halloran, Teresa K Woodruff

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e58491 (2013)

Advances in cancer therapy have increased the rate of survival of young cancer patients; however, female lymphoma patients frequently face a temporary or permanent loss of fertility when treated with traditional cytotoxic agents. The potential loss o

Externí odkaz: https://doaj.org/article/629387cc7d7a46b4b5bc03d165b05f02

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Akademický článek

Elevated PLAUR is observed in the airway epithelium of asthma patients and blocking improves barrier integrity

Autor: Michael A. Portelli, Sangita Bhaker, Vincent Pang, David O. Bates, Simon R. Johnson, Andrew P. Mazar, Dominick Shaw, Christopher Brightling, Ian Sayers

Publikováno v: Clinical and Translational Allergy, Vol 13, Iss 10, Pp n/a-n/a (2023)

Abstract Background Expression of the urokinase plasminogen activator receptor (uPAR) is elevated in the airway epithelium in asthma; however, the contribution of uPAR to asthma pathogenesis and scope for therapeutic targeting remains unknown. Object

Externí odkaz: https://doaj.org/article/b98b2138b6a345bba5e4c156f9115f19

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Akademický článek

9-ING-41, a small molecule inhibitor of GSK-3beta, potentiates the effects of anticancer therapeutics in bladder cancer

Autor: Hiroo Kuroki, Tsutomu Anraku, Akira Kazama, Vladimir Bilim, Masayuki Tasaki, Daniel Schmitt, Andrew P. Mazar, Francis J Giles, Andrey Ugolkov, Yoshihiko Tomita

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)

Abstract Glycogen synthase kinase-3 beta (GSK-3β), a serine/threonine kinase, has been identified as a potential therapeutic target in human bladder cancer. In the present study, we investigated the antitumor effect of a small molecule GSK-3β inhib

Externí odkaz: https://doaj.org/article/1423d830529042219401ce10296db960

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