Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Andrew P Degnan"'
Autor:
Chan Gao, Michael Quigley, Dandan Zhao, Jennifer Koenitzer, Dan You, Stephen Hillerman, Gregory Locke, Charu Chaudhry, Caitlyn Stromko, Anwar Murtaza, Yi Fan, Yali Chen, Stephanie Briceno, Elizabeth Duperret, Johnni Gullo-Brown, John Feder, Joshua Curtin, Andrew P Degnan, Godwin Kumi, Mark Wittman, Benjamin M Johnson, Karen E Parrish, Giridharan Gokulrangan, John T Hunt, Luisa Salter-Cid, Emma Lees, Jinqi Liu
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 1 (2021)
Background Hematopoietic progenitor kinase 1 (HPK1 or MAP4K1) has been demonstrated as a negative intracellular immune checkpoint in mediating antitumor immunity in studies with HPK1 knockout and kinase dead mice. Pharmacological inhibition of HPK1 i
Externí odkaz:
https://doaj.org/article/ca18b70501584617bef15c4ef9806fc2
Autor:
Andrew J. Degnan, Victor M. Ho-Fung, Rebecca C. Ahrens-Nicklas, Christian A. Barrera, Suraj D. Serai, Dah-Jyuu Wang, Can Ficicioglu
Publikováno v:
Insights into Imaging, Vol 10, Iss 1, Pp 1-19 (2019)
Abstract Gaucher disease is an inherited metabolic disorder resulting in deficiency of lysosomal enzyme β-glucocerebrosidase causing the accumulation of abnormal macrophages (“Gaucher cells”) within multiple organs, most conspicuously affecting
Externí odkaz:
https://doaj.org/article/0f344bca3c1d4b459ab938f4eb4842c5
Autor:
Laura T. Haas, Santiago V. Salazar, Levi M. Smith, Helen R. Zhao, Timothy O. Cox, Charlotte S. Herber, Andrew P. Degnan, Anand Balakrishnan, John E. Macor, Charles F. Albright, Stephen M. Strittmatter
Publikováno v:
Cell Reports, Vol 20, Iss 1, Pp 76-88 (2017)
Metabotropic glutamate receptor 5 (mGluR5) has been implicated in Alzheimer’s disease (AD) pathology. We sought to understand whether mGluR5’s role in AD requires glutamate signaling. We used a potent mGluR5 silent allosteric modulator (SAM, BMS-
Externí odkaz:
https://doaj.org/article/5b136f6e60cd4bbaa20c897785936a15
Autor:
Andrew J. Degnan, MD, MPhil, Kenneth K.W. Lee, MD, Marta I. Minervini, MD, Amir A. Borhani, MD
Publikováno v:
Radiology Case Reports, Vol 12, Iss 1, Pp 113-119 (2017)
We report a rare case of metastatic malignant solitary fibrous tumor (SFT) that presented with hypoglycemia because of insulin growth factor-2 production. Initial workup included computed tomography imaging that revealed a large, partially necrotic l
Externí odkaz:
https://doaj.org/article/13cde59c43ce4caab4ddd38a74a75de9
Autor:
Matthew D. Hill, Haiquan Fang, Derek Norris, George V. Delucca, Hong Huang, Mikkel DeBenedetto, Claude Quesnelle, William D. Schmitz, John S. Tokarski, Steven Sheriff, Chunhong Yan, Caroline Fanslau, Zuzana Haarhoff, Christine Huang, Melissa Kramer, Shilpa Madari, Krista Menard, Laura Monereau, John Morrison, Nirmala Raghavan, Eric E. Shields, Jean Simmermacher-Mayer, Michael Sinz, Ching Kim Tye, Richard Westhouse, Chunshan Xie, Haiying Zhang, Lisa Zhang, Tatyana Zvyaga, Francis Lee, Ashvinikumar V. Gavai, Andrew P. Degnan
Publikováno v:
ACS Medicinal Chemistry Letters. 13:1165-1171
We describe the synthesis of triazole-containing carboline derivatives and their utility as bromodomain and extra-terminal (BET) inhibitors. A convergent synthetic route permitted the detailed investigation of deuteration and fluorination strategies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e35ad654e0ca7192653d0e07258cff5
https://doi.org/10.1021/acsmedchemlett.2c00219
https://doi.org/10.1021/acsmedchemlett.2c00219
Autor:
John Morrison, Steven Sheriff, Mark D. Wittman, Gregory A. Locke, Bradley C. Pearce, Erika M. V. Araujo, Andrew P. Degnan, Christopher W. Allard, Dan You, Xin Li, Kurt Zimmermann, Anwar Murtaza, Benjamin M. Johnson, Caitlyn Stromko, Jinqi Liu, Gregory D. Vite, Godwin Kwame Kumi, Karen E. Parrish, Alan Futran, Johnson Walter Lewis
Publikováno v:
ACS Medicinal Chemistry Letters
While the discovery of immune checkpoint inhibitors has led to robust, durable responses in a range of cancers, many patients do not respond to currently available therapeutics. Therefore, an urgent need exists to identify alternative mechanisms to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe8d6f32c2573a82ac07636c7d82958e
https://doi.org/10.1021/acsmedchemlett.0c00660
https://doi.org/10.1021/acsmedchemlett.0c00660
Autor:
Andrew P. Degnan, Yeheng Zhu, Peter T. W. Cheng, Shasha Zhang, Alicia Regueiro-Ren, Sarah C. Traeger, Amy A. Sarjeant, Bruce A. Ellsworth, Bhupinder Sandhu, Darpandeep Aulakh, Ketleine Georges, Michael D Mandler
Publikováno v:
Organic letters. 24(3)
Owing to their participation in Click reactions, bifunctional azides are valuable intermediates in the preparation of medicines and biochemical tool compounds. Despite the privileged nature of pyridines among pharmaceutical scaffolds, reports of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31f9f07b0c38696eb867a1af4c28c711
https://pubmed.ncbi.nlm.nih.gov/34714083
https://pubmed.ncbi.nlm.nih.gov/34714083
Autor:
Andrew J Degnan, Jessica L Wisnowski, SoYoung Choi, Rafael Ceschin, Chitresh Bhushan, Richard M Leahy, Patricia Corby, Vincent J Schmithorst, Ashok Panigrahy
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130686 (2015)
Late preterm birth confers increased risk of developmental delay, academic difficulties and social deficits. The late third trimester may represent a critical period of development of neural networks including the default mode network (DMN), which is
Externí odkaz:
https://doaj.org/article/7cd042dc1aaa4840826079f8ed4a2507
Autor:
Andrew P. Degnan, Haiquan Fang, Tatyana Zvyaga, Zuzana Haarhoff, Claude A. Quesnelle, Melissa Kramer, Frank Marsilio, Richard A. Westhouse, John S. Tokarski, Shilpa Madari, Jiuqiao Zhao, Amy Wiebesiek, Chunhong Yan, Francis Y. Lee, Michael Sinz, John Morrison, Jean Simmermacher-Mayer, Carolynn Fanslau, Steven Sheriff, Lisa Huang, Ashvinikumar V. Gavai, Chunshan Xie, Matthew D. Hill, Gerry Everlof
Publikováno v:
Bioorganicmedicinal chemistry letters. 51
We describe our efforts to introduce structural diversity to a previously described triazole-containing N1-carboline series of bromodomain and extra-terminal (BET) inhibitors. N9 carbolines were designed to retain favorable binding interactions that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ada735600c02c9c410a77e52ab96e515
https://pubmed.ncbi.nlm.nih.gov/34560263
https://pubmed.ncbi.nlm.nih.gov/34560263
Publikováno v:
Radiology Research and Practice, Vol 2014 (2014)
Externí odkaz:
https://doaj.org/article/778f999f6acf4109a37f80b7806478fd