Zobrazeno 1 - 10
of 379
pro vyhledávání: '"Andrew P Cap"'
Autor:
Yansong Li, Zhangsheng Yang, Milomir O Simovic, Matthew B Burgess, Andrew P Cap, Jurandir J DalleLucca
Publikováno v:
Trauma Surgery & Acute Care Open, Vol 7, Iss 1 (2022)
Objectives Early complementopathy and coagulopathy are shown often after trauma. However, the prevalence of any interplay between complement cascade (ComC) and coagulation cascade (CoaC) after trauma remains unclear. This study intended to explore wh
Externí odkaz:
https://doaj.org/article/ee30676617574a7eb7a3678520b2cd4a
Autor:
Heather F Pidcoke, Wilfred Delacruz, Maryanne C Herzig, Beverly S Schaffer, Sahar T Leazer, Chriselda G Fedyk, Robbie K Montogomery, Nicolas J Prat, Bijaya K Parida, James K Aden, Michael R Scherer, Robert L Reddick, Robert E Shade, Andrew P Cap
Publikováno v:
PLoS ONE, Vol 17, Iss 12, p e0279694 (2022)
A perfluorocarbon (PFC) investigated for treatment of traumatic brain injury (TBI) delivers oxygen to support brain function, but causes transient thrombocytopenia. TBI can cause acute inflammation with resulting thrombocytopenia; an interaction betw
Externí odkaz:
https://doaj.org/article/ecc3faad40b14eefb38de77adbf4c278
Autor:
Morten Zaar, Maryanne C Herzig, Chriselda G Fedyk, Robbie K Montgomery, Nicolas Prat, Bijaya K Parida, Carmen Hinojosa-Laborde, Gary W Muniz, Robert E Shade, Cassondra Bauer, Wilfred Delacruz, James A Bynum, Victor A Convertino, Andrew P Cap, Heather F Pidcoke
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0234844 (2020)
BackgroundTo study central hypovolemia in humans, lower body negative pressure (LBNP) is a recognized alternative to blood removal (HEM). While LBNP mimics the cardiovascular responses of HEM in baboons, similarities in hemostatic responses to LBNP a
Externí odkaz:
https://doaj.org/article/86bac304f8d74fe7894e677ebbd29954
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0223406 (2019)
Trauma and hemorrhagic shock can lead to acute traumatic coagulopathy (ATC) that is not fully reversed by prehospital resuscitation as simulated with a limited volume of fresh whole blood (FWB) in a rat model. Tranexamic Acid (TXA) is used as an anti
Externí odkaz:
https://doaj.org/article/979dcdc6e15c4d618c94cea20e824721
Autor:
Holly C May, Jieh-Juen Yu, Hao Zhang, Yufeng Wang, Andrew P Cap, James P Chambers, M Neal Guentzel, Bernard P Arulanandam
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0218505 (2019)
The Gram-negative pathogen, Acinetobacter baumannii has emerged as a global nosocomial health threat affecting the majority of hospitals in the U.S. and abroad. The redox protein thioredoxin has been shown to play several roles in modulation of cellu
Externí odkaz:
https://doaj.org/article/f0277587ce5849879d3271de32865c51
Autor:
Jeremy W. Cannon, Danielle S. Gruen, Ruben Zamora, Noah Brostoff, Kelly Hurst, John H. Harn, Fayten El-Dehaibi, Zhi Geng, Rami Namas, Jason L. Sperry, John B. Holcomb, Bryan A. Cotton, Jason J. Nam, Samantha Underwood, Martin A. Schreiber, Kevin K. Chung, Andriy I. Batchinsky, Leopoldo C. Cancio, Andrew J. Benjamin, Erin E. Fox, Steven C. Chang, Andrew P. Cap, Yoram Vodovotz
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-12 (2024)
Abstract Background Optimizing resuscitation to reduce inflammation and organ dysfunction following human trauma-associated hemorrhagic shock is a major clinical hurdle. This is limited by the short duration of pre-clinical studies and the sparsity o
Externí odkaz:
https://doaj.org/article/4ec280b49b694ff292ab1c9cd28a37b5
Autor:
Martin G Schwacha, Meenakshi Rani, Susannah E Nicholson, Aaron M Lewis, Travis L Holloway, Salvador Sordo, Andrew P Cap
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158993 (2016)
Gamma delta T-cells have been shown to be important to the early immunoinflammatory response to injury, independent of infection. This unique T-cell population acts to regulate cell trafficking and the release of cytokines and growth factors. We prop
Externí odkaz:
https://doaj.org/article/39480f1a58274fff9dfb17e50f80e53f
Autor:
Shradha Wali, Rishein Gupta, Ronald L Veselenak, Yansong Li, Jieh-Juen Yu, Ashlesh K Murthy, Andrew P Cap, M Neal Guentzel, James P Chambers, Guangming Zhong, Roger G Rank, Richard B Pyles, Bernard P Arulanandam
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114261 (2014)
Guinea pigs have been used as a second animal model to validate putative anti-chlamydial vaccine candidates tested in mice. However, the lack of guinea pig-specific reagents has limited the utility of this animal model in Chlamydia sp. vaccine studie
Externí odkaz:
https://doaj.org/article/39edd571e0464c3eb0f118ba2a8f5bdc
Autor:
Morten Zaar, Chriselda G Fedyk, Heather F Pidcoke, Michael R Scherer, Kathy L Ryan, Caroline A Rickards, Carmen Hinojosa-Laborde, Victor A Convertino, Andrew P Cap
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e116174 (2014)
Central hypovolemia elevates hemostatic activity which is essential for preventing exsanguination after trauma, but platelet activation to central hypovolemia has not been described. We hypothesized that central hypovolemia induced by lower body nega
Externí odkaz:
https://doaj.org/article/fee438bd1c7d4745aaa8d2a332d9c94b
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99181 (2014)
BACKGROUND: Acute traumatic coagulopathy (ATC) has been linked to an increase in activated protein C (aPC) from 40 pM in healthy individuals to 175 pM. aPC exerts its activity primarily through cleavage of active coagulation factor Va (fVa). Platelet
Externí odkaz:
https://doaj.org/article/0027f0e280e3411a93f9fd732a751eda