Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Andrew P, Trotta"'
Autor:
Royce W. Zhou, Jia Xu, Tiphaine C. Martin, Alexis L. Zachem, John He, Sait Ozturk, Deniz Demircioglu, Ankita Bansal, Andrew P. Trotta, Bruno Giotti, Berkley Gryder, Yao Shen, Xuewei Wu, Saul Carcamo, Kaitlyn Bosch, Benjamin Hopkins, Alexander Tsankov, Randolph Steinhagen, Drew R. Jones, John Asara, Jerry E. Chipuk, Rachel Brody, Steven Itzkowitz, Iok In Christine Chio, Dan Hasson, Emily Bernstein, Ramon E. Parsons
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The changes in super-enhancer (SE) landscape of cancers are mainly attributed to cell-intrinsic genomic alterations. Here, the authors perform epigenomic profiling on primary colorectal cancers (CRCs) and their matched normal tissues and show that lo
Externí odkaz:
https://doaj.org/article/160f539e4f1344ce8856c7dd4c65e157
Autor:
Royce W. Zhou, Jia Xu, Tiphaine C. Martin, Alexis L. Zachem, John He, Sait Ozturk, Deniz Demircioglu, Ankita Bansal, Andrew P. Trotta, Bruno Giotti, Berkley Gryder, Yao Shen, Xuewei Wu, Saul Carcamo, Kaitlyn Bosch, Benjamin Hopkins, Alexander Tsankov, Randolph Steinhagen, Drew R. Jones, John Asara, Jerry E. Chipuk, Rachel Brody, Steven Itzkowitz, Iok In Christine Chio, Dan Hasson, Emily Bernstein, Ramon E. Parsons
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/9c2c6cb8439a47878da63f05bb8f178d
Autor:
John M. Asara, Jerry E. Chipuk, Shen Yao, Andrew P. Trotta, Bruno Giotti, Emily Bernstein, Xuewei Wu, Saul Carcamo, Christine Chio, Ramon Parsons, Kaitlyn Bosch, Royce Zhou, Ankita Bansal, Drew Jones, John Z. He, Jia Xu, Benjamin D. Hopkins, Rachel Brody, Sait Ozturk, Tiphaine Martin, Berkley E. Gryder, Steven Itzkowitz, Alexander M. Tsankov, Dan Hasson, Alexis Zachem, Randolph Steinhagen
Tumors exhibit widespread enhancer landscape reprogramming compared to normal tissue. The etiology is believed to be largely cell-intrinsic in non-hormonal cancers, attributed to such genomic alterations as focal amplification of non-coding regions,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5fb2a9091a3f450678e41bf8cd8d18b
https://doi.org/10.21203/rs.3.rs-799320/v1
https://doi.org/10.21203/rs.3.rs-799320/v1
Publikováno v:
Biochemical Pharmacology. 162:14-20
Decades of research reveal that MDM2 participates in cellular processes ranging from macro-molecular metabolism to cancer signaling mechanisms. Two recent studies uncovered a new role for MDM2 in mitochondrial bioenergetics. Through the negative regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::485a3dc5f94459079f3b38ef1a7ffa82
https://doi.org/10.1016/j.bcp.2018.10.032
https://doi.org/10.1016/j.bcp.2018.10.032
Autor:
Zahra Zakeri, Camila Rubio-Patiño, Jesse D. Gelles, Richard A. Lockshin, Jerry E. Chipuk, Jarvier N. Mohammed, Madhavika N. Serasinghe, Andrew P. Trotta
Publikováno v:
FEBS J
In June of 2019, the International Cell Death Society (ICDS) held its 25th anniversary meeting in New York City at the Icahn School of Medicine at Mount Sinai organized by Drs. Richard A. Lockshin (St. John's University, USA), Zahra Zakeri (Queens Co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca837c92d1db30b80e9a70d8f24625a0
https://europepmc.org/articles/PMC7703806/
https://europepmc.org/articles/PMC7703806/
Autor:
Jerry E. Chipuk, Jack L. Arbiser, Jesse D. Gelles, Andrew P. Trotta, Madhavika N. Serasinghe, Patrick Loi
Publikováno v:
Journal of Biological Chemistry. 292:11727-11739
The mitochondrial network is a major site of ATP production through the coupled integration of the electron transport chain (ETC) with oxidative phosphorylation. In melanoma arising from the V600E mutation in the kinase v-RAF murine sarcoma viral onc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d60bf183749a3380d3a391b824d2a38
https://doi.org/10.1074/jbc.m117.786442
https://doi.org/10.1074/jbc.m117.786442
Autor:
Andrew P. Trotta, Donald K. Scott, Weijia Zhang, Francisco Victorino, Kevin Jhun, Eric T. Clambey, Jens Eberlein, Bennett Davenport, Jerry E. Chipuk, Tom T. Nguyen, Zhengzi Yi, Dirk Homann, Verena van der Heide
Aging of established antiviral T cell memory fosters a series of progressive adaptations that paradoxically improve rather than compromise protective CD8+T cell immunity. We now provide evidence that this gradual evolution, the pace of which is conti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8eedd47549829aef46c90fc79368c62
https://europepmc.org/articles/PMC6358025/
https://europepmc.org/articles/PMC6358025/
Autor:
Damien A. Leach, Paul A. Drew, David Tamblyn, Tina Kopsaftis, Samarth Chopra, Gail P. Risbridger, Carole B Pinnock, Roxanne Toivanen, Renea A. Taylor, Eric Smith, Grant Buchanan, Donald B. DeFranco, Eleanor F. Need, Jeff Holst, Georgina M. England, Peng Lee, Andrew P. Trotta, Helen M. Palethorpe
Publikováno v:
ResearcherID
Oncotarget
Oncotarget
Androgen receptor (AR) signaling in stromal cells is important in prostate cancer, yet the mechanisms underpinning stromal AR contribution to disease development and progression remain unclear. Using patient-matched benign and malignant prostate samp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::682c7ee953d034fb703f75faeb131318
https://doi.org/10.18632/oncotarget.3873
https://doi.org/10.18632/oncotarget.3873
Autor:
Jerry E. Chipuk, Andrew P. Trotta
Mitochondria are dynamic organelles that supply energy required to drive key cellular processes, such as survival, proliferation, and migration. Critical to all of these processes are changes in mitochondrial architecture, a mechanical mechanism enco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bba10c65799fb8e8e32f666ae3f2e6f9
https://europepmc.org/articles/PMC5419868/
https://europepmc.org/articles/PMC5419868/
Autor:
Renea A. Taylor, Eleanor F. Need, Gail P. Risbridger, Luc Furic, John Pedersen, Mark Frydenberg, Bree Cawsey, Stuart John Ellem, Grant Buchanan, Andrew P. Trotta, Ola Larsson, David Pook
Publikováno v:
The Journal of Pathology. 234:86-98
Prostate cancer is hormone-dependent and regulated by androgens as well as oestrogens. The tumour microenvironment also provides regulatory control, but the balance and interplay between androgens and oestrogens at the human prostate tumour interface
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531af7b100f7f170d77e6249044f2757
https://doi.org/10.1002/path.4386
https://doi.org/10.1002/path.4386