Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Andrew P, Herbert"'
Autor:
Surender Khurana, Gabrielle Grubbs, Supriya Ravichandran, Emily Cluff, JungHyun Kim, Ana I. Kuehne, Samantha Zak, John M. Dye, Julius J. Lutwama, Andrew S. Herbert
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Limited knowledge exists on the quality of polyclonal antibody responses generated following Marburg virus (MARV) infection and its evolution in survivors. In this study, we evaluate MARV proteome-wide antibody repertoire longitudinally in c
Externí odkaz:
https://doaj.org/article/9b784c44b75a49e2a60b6d1f5a8be3ea
Autor:
Hung Caohuy, Ofer Eidelman, Tinghua Chen, Ognoon Mungunsukh, Qingfeng Yang, Nathan I. Walton, Bette S. Pollard, Sara Khanal, Shannon Hentschel, Catalina Florez, Andrew S. Herbert, Harvey B. Pollard
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract SARS-CoV-2-contributes to sickness and death in COVID-19 patients partly by inducing a hyper-proinflammatory immune response in the host airway. This hyper-proinflammatory state involves activation of signaling by NFκB, and unexpectedly, EN
Externí odkaz:
https://doaj.org/article/7a2225a402c0400ca2a99fa970f2b2ac
Autor:
Olivia S. Shin, Stephanie R. Monticelli, Christy K. Hjorth, Vladlena Hornet, Michael Doyle, Dafna Abelson, Ana I. Kuehne, Albert Wang, Russell R. Bakken, Akaash K. Mishra, Marissa Middlecamp, Elizabeth Champney, Lauran Stuart, Daniel P. Maurer, Jiannan Li, Jacob Berrigan, Jennifer Barajas, Stephen Balinandi, Julius J. Lutwama, Leslie Lobel, Larry Zeitlin, Laura M. Walker, John M. Dye, Kartik Chandran, Andrew S. Herbert, Noel T. Pauli, Jason S. McLellan
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114502- (2024)
Summary: Crimean-Congo hemorrhagic fever virus can cause lethal disease in humans yet there are no approved medical countermeasures. Viral glycoprotein GP38, exclusive to Nairoviridae, is a target of protective antibodies and is a key antigen in prec
Externí odkaz:
https://doaj.org/article/d783005edd1a4330be69737cbfd33c17
Autor:
Ariel S Wirchnianski, Elisabeth K Nyakatura, Andrew S Herbert, Ana I Kuehne, Shawn A Abbasi, Catalina Florez, Nadia Storm, Lindsay G A McKay, Leandrew Dailey, Erin Kuang, Dafna M Abelson, Anna Z Wec, Srinjoy Chakraborti, Frederick W Holtsberg, Sergey Shulenin, Zachary A Bornholdt, M Javad Aman, Anna N Honko, Anthony Griffiths, John M Dye, Kartik Chandran, Jonathan R Lai
Publikováno v:
PLoS Pathogens, Vol 20, Iss 4, p e1012134 (2024)
Monoclonal antibodies (mAbs) are an important class of antiviral therapeutics. MAbs are highly selective, well tolerated, and have long in vivo half-life as well as the capacity to induce immune-mediated virus clearance. Their activities can be furth
Externí odkaz:
https://doaj.org/article/2302156227ee41508fe68701e955e1ae
Autor:
Megan M. Slough, Rong Li, Andrew S. Herbert, Gorka Lasso, Ana I. Kuehne, Stephanie R. Monticelli, Russell R. Bakken, Yanan Liu, Agnidipta Ghosh, Alicia M. Moreau, Xiankun Zeng, Félix A. Rey, Pablo Guardado-Calvo, Steven C. Almo, John M. Dye, Rohit K. Jangra, Zhongde Wang, Kartik Chandran
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Andes virus (ANDV) and Sin Nombre virus (SNV) are the etiologic agents of severe hantavirus cardiopulmonary syndrome (HCPS) in the Americas for which no FDA-approved countermeasures are available. Protocadherin-1 (PCDH1), a cadherin-superfam
Externí odkaz:
https://doaj.org/article/f3b912d0b0034e259a6b83f7a5d19e50
Autor:
Kevin M. Taylor, MD, Keersten M. Ricks, PhD, Paul A. Kuehnert, MS, Angelia A. Eick-Cost, PhD, Mark R. Scheckelhoff, PhD, Andrew R. Wiesen, MD, Tamara L. Clements, MS, Zheng Hu, MS, Samantha E. Zak, MS, Scott P. Olschner, BS, Andrew S. Herbert, PhD, Sara L. Bazaco, PhD, Kathleen E. Creppage, DrPH, Michael T. Fan, PhD, Jose L. Sanchez, MD
Publikováno v:
AJPM Focus, Vol 2, Iss 4, Pp 100141- (2023)
Introduction: Reported confirmed cases represent a small portion of overall true cases for many infectious diseases. The undercounting of true cases can be considerable when a significant portion of infected individuals are asymptomatic or minimally
Externí odkaz:
https://doaj.org/article/46f890f1f6904f0f8de6f3960c5f05ce
Autor:
Elizabeth E. Zumbrun, Samantha E. Zak, Eric D. Lee, Philip A. Bowling, Sara I. Ruiz, Xiankun Zeng, Jeffrey W. Koehler, Korey L. Delp, Russel R. Bakken, Shannon S. Hentschel, Holly A. Bloomfield, Keersten M. Ricks, Tamara L. Clements, April M. Babka, John M. Dye, Andrew S. Herbert
Publikováno v:
Viruses, Vol 15, Iss 12, p 2341 (2023)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the worldwide COVID-19 pandemic. Animal models are extremely helpful for testing vaccines and therapeutics and for dissecting the viral and host factors that contr
Externí odkaz:
https://doaj.org/article/bd56c47970434e62b1faeb69e1895bd8
Autor:
Megan M. Slough, Rong Li, Andrew S. Herbert, Gorka Lasso, Ana I. Kuehne, Stephanie R. Monticelli, Russell R. Bakken, Yanan Liu, Agnidipta Ghosh, Alicia M. Moreau, Xiankun Zeng, Félix A. Rey, Pablo Guardado-Calvo, Steven C. Almo, John M. Dye, Rohit K. Jangra, Zhongde Wang, Kartik Chandran
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/f8d2de5ecf62478da3f9d3cfafd25d6d
Autor:
Ariel S. Wirchnianski, Anna Z. Wec, Elisabeth K. Nyakatura, Andrew S. Herbert, Megan M. Slough, Ana I. Kuehne, Eva Mittler, Rohit K. Jangra, Jonathan Teruya, John M. Dye, Jonathan R. Lai, Kartik Chandran
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Multiple agents in the family Filoviridae (filoviruses) are associated with sporadic human outbreaks of highly lethal disease, while others, including several recently identified agents, possess strong zoonotic potential. Although viral glycoprotein
Externí odkaz:
https://doaj.org/article/1d84663bcc6e467aadf399bd6699d39f
Autor:
Denise Haslwanter, M. Eugenia Dieterle, Anna Z. Wec, Cecilia M. O’Brien, Mrunal Sakharkar, Catalina Florez, Karen Tong, C. Garrett Rappazzo, Gorka Lasso, Olivia Vergnolle, Ariel S. Wirchnianski, Robert H. Bortz, Ethan Laudermilch, J. Maximilian Fels, Amanda Mengotto, Ryan J. Malonis, George I. Georgiev, Jose A. Quiroz, Daniel Wrapp, Nianshuang Wang, Kathryn E. Dye, Jason Barnhill, John M. Dye, Jason S. McLellan, Johanna P. Daily, Jonathan R. Lai, Andrew S. Herbert, Laura M. Walker, Kartik Chandran, Rohit K. Jangra
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
The U.S. FDA has issued emergency use authorizations (EUAs) for multiple investigational monoclonal antibody (MAb) therapies for the treatment of mild to moderate COVID-19.
Externí odkaz:
https://doaj.org/article/679d11cbba69478ca30bdf9534e81939