Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Andrew N. J. Tutt"'
Autor:
Joseph S. Baxter, Rachel Brough, Dragomir B. Krastev, Feifei Song, Sandhya Sridhar, Aditi Gulati, John Alexander, Theodoros I. Roumeliotis, Zuza Kozik, Jyoti S. Choudhary, Syed Haider, Stephen J. Pettitt, Andrew N. J. Tutt, Christopher J. Lord
Publikováno v:
Molecular Oncology, Vol 18, Iss 2, Pp 369-385 (2024)
The F‐box and WD repeat domain containing 7 (FBXW7) tumour suppressor gene encodes a substrate‐recognition subunit of Skp, cullin, F‐box (SCF)‐containing complexes. The tumour‐suppressive role of FBXW7 is ascribed to its ability to drive ub
Externí odkaz:
https://doaj.org/article/394126b61bef4541813ab49cbc06b55c
Autor:
Amanda Fitzpatrick, Marjan Iravani, Adam Mills, David Vicente, Thanussuyah Alaguthurai, Ioannis Roxanis, Nicholas C. Turner, Syed Haider, Andrew N. J. Tutt, Clare M. Isacke
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Breast cancer leptomeningeal metastasis (BCLM), where tumour cells grow along the lining of the brain and spinal cord, is a devastating development for patients. Investigating this metastatic site is hampered by difficulty in accessing tumou
Externí odkaz:
https://doaj.org/article/20b3868c6f4d4c9fb06a83eaa7a15e4e
Autor:
Ilirjana Bajrami, Callum Walker, Dragomir B. Krastev, Daniel Weekes, Feifei Song, Andrew J. Wicks, John Alexander, Syed Haider, Rachel Brough, Stephen J. Pettitt, Andrew N. J. Tutt, Christopher J. Lord
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Bajrami, Walker et al. investigated the synthetic lethality between BRCA gene defects and inhibition of two sirtuin genes, SIRT1 or SIRT6, which was found to be associated with replication stress and increased PARylation. The authors demonstrated tha
Externí odkaz:
https://doaj.org/article/d5f5e8c9681d4c1cb2934f06ed9a1386
Autor:
Andrew J. Wicks, Dragomir B. Krastev, Stephen J. Pettitt, Andrew N. J. Tutt, Christopher J. Lord
Publikováno v:
Open Biology, Vol 12, Iss 7 (2022)
PARP inhibitors (PARPi) have been demonstrated to exhibit profound anti-tumour activity in individuals whose cancers have a defect in the homologous recombination DNA repair pathway. Here, we describe the current consensus as to how PARPi work and ho
Externí odkaz:
https://doaj.org/article/4b60bfc0f8324ff39565168634c77471
Autor:
Nirmesh Patel, Daniel Weekes, Konstantinos Drosopoulos, Patrycja Gazinska, Elodie Noel, Mamun Rashid, Hasan Mirza, Jelmar Quist, Fara Brasó-Maristany, Sumi Mathew, Riccardo Ferro, Ana Mendes Pereira, Cynthia Prince, Farzana Noor, Erika Francesch-Domenech, Rebecca Marlow, Emanuele de Rinaldis, Anita Grigoriadis, Spiros Linardopoulos, Pierfrancesco Marra, Andrew N. J. Tutt
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Triple negative breast cancers harbor multiple copy number aberrations driving gene expression changes thought to underpin their malignant phenotypes. Here the authors integrate these features, finding and functionally validating 37 gene addictions a
Externí odkaz:
https://doaj.org/article/5040e6ddb1d140d09e37fbc06a8ca400
Autor:
Isabel Correa, Kristina M. Ilieva, Silvia Crescioli, Sara Lombardi, Mariangela Figini, Anthony Cheung, James F. Spicer, Andrew N. J. Tutt, Frank O. Nestle, Panagiotis Karagiannis, Katie E. Lacy, Sophia N. Karagiannis
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Selection of single antigen-specific B cells to identify their expressed antibodies is of considerable interest for evaluating human immune responses. Here, we present a method to identify single antibody-expressing cells using antigen-conjugated flu
Externí odkaz:
https://doaj.org/article/cb0cbc0379c746849a53358ab0382878
Autor:
Kristina M. Ilieva, Anthony Cheung, Silvia Mele, Giulia Chiaruttini, Silvia Crescioli, Merope Griffin, Mano Nakamura, James F. Spicer, Sophia Tsoka, Katie E. Lacy, Andrew N. J. Tutt, Sophia N. Karagiannis
Publikováno v:
Frontiers in Immunology, Vol 8 (2018)
Overexpression of the chondroitin sulfate proteoglycan 4 (CSPG4) has been associated with the pathology of multiple types of such as melanoma, breast cancer, squamous cell carcinoma, mesothelioma, neuroblastoma, adult and pediatric sarcomas, and some
Externí odkaz:
https://doaj.org/article/3801405dd54c4adfb1cbc1ca7e753a35
Autor:
Anabel Zelceski, Paola Francica, Lea Lingg, Merve Mutlu, Colin Stok, Martin Liptay, John Alexander, Joseph S. Baxter, Rachel Brough, Aditi Gulati, Syed Haider, Maya Raghunandan, Feifei Song, Sandhya Sridhar, Josep V. Forment, Mark J. O’Connor, Barry R. Davies, Marcel A.T.M. van Vugt, Dragomir B. Krastev, Stephen J. Pettitt, Andrew N. J. Tutt, Sven Rottenberg, Christopher J. Lord
Publikováno v:
Zelceski, Anabel; Francica, Paola; Lingg, Lea; Mutlu, Merve; Stok, Colin; Liptay, Martin; Alexander, John; Baxter, Joseph S; Brough, Rachel; Gulati, Aditi; Haider, Syed; Raghunandan, Maya; Song, Feifei; Sridhar, Sandhya; Forment, Josep V; O'Connor, Mark J; Davies, Barry R; van Vugt, Marcel A T M; Krastev, Dragomir B; Pettitt, Stephen J; ... (2023). MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells. Cell reports, 42(5), p. 112484. Cell Press 10.1016/j.celrep.2023.112484
Cell reports, 42(5):112484. CELL PRESS
Cell reports, 42(5):112484. CELL PRESS
The PSMC3IP-MND1 heterodimer promotes RAD51 and DMC1-dependent D-loop formation during meiosis in yeast and mammalian organisms. For this purpose, it catalyzes the DNA strand exchange activities of the recombinases. Interestingly, in a panel of genom
Publikováno v:
The New England journal of medicine. 385(15)
Autor:
Dragomir B, Krastev, Shudong, Li, Yilun, Sun, Andrew J, Wicks, Gwendoline, Hoslett, Daniel, Weekes, Luned M, Badder, Eleanor G, Knight, Rebecca, Marlow, Mercedes Calvo, Pardo, Lu, Yu, Tanaji T, Talele, Jiri, Bartek, Jyoti S, Choudhary, Yves, Pommier, Stephen J, Pettitt, Andrew N J, Tutt, Kristijan, Ramadan, Christopher J, Lord
Publikováno v:
Nature cell biology. 24(1)
Poly (ADP-ribose) polymerase (PARP) inhibitors elicit antitumour activity in homologous recombination-defective cancers by trapping PARP1 in a chromatin-bound state. How cells process trapped PARP1 remains unclear. Using wild-type and a trapping-defi