Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Andrew N. Stephens"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 19, p 10554 (2024)
Metastasis is the leading cause of cancer-related mortality; however, a complete understanding of the molecular programs driving the metastatic cascade is lacking. Metastasis is dependent on collective invasion—a developmental process exploited by
Externí odkaz:
https://doaj.org/article/88b309b83e2e4a28ad5392e386cbb854
Autor:
Andrew N. Stephens, Simon J. Hobbs, Sung-Woog Kang, Martin K. Oehler, Tom W. Jobling, Richard Allman
Publikováno v:
Diagnostics, Vol 14, Iss 7, p 671 (2024)
Pre-surgical clinical assessment of an adnexal mass is a complex process, and ideally requires accurate and rapid identification of disease status. Gold standard biomarker CA125 is extensively used off-label for this purpose; however its performance
Externí odkaz:
https://doaj.org/article/1568315bfe9741edb1e0755dc4e4414e
Autor:
Nazanin Karimnia, Amy L. Wilson, Emma Green, Amelia Matthews, Thomas W. Jobling, Magdalena Plebanski, Maree Bilandzic, Andrew N. Stephens
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-13 (2021)
Abstract Background Leader cells are a subset of cancer cells that coordinate the complex cell-cell and cell-matrix interactions required for ovarian cancer migration, invasion, tumour deposition and are negatively associated with progression-free su
Externí odkaz:
https://doaj.org/article/3a4f2b92608642eb89cf00da7af241cc
Autor:
Dane Cheasley, Matthew J. Wakefield, Georgina L. Ryland, Prue E. Allan, Kathryn Alsop, Kaushalya C. Amarasinghe, Sumitra Ananda, Michael S. Anglesio, George Au-Yeung, Maret Böhm, David D. L. Bowtell, Alison Brand, Georgia Chenevix-Trench, Michael Christie, Yoke-Eng Chiew, Michael Churchman, Anna DeFazio, Renee Demeo, Rhiannon Dudley, Nicole Fairweather, Clare G. Fedele, Sian Fereday, Stephen B. Fox, C Blake Gilks, Charlie Gourley, Neville F. Hacker, Alison M. Hadley, Joy Hendley, Gwo-Yaw Ho, Siobhan Hughes, David G. Hunstman, Sally M. Hunter, Tom W. Jobling, Kimberly R. Kalli, Scott H. Kaufmann, Catherine J. Kennedy, Martin Köbel, Cecile Le Page, Jason Li, Richard Lupat, Orla M. McNally, Jessica N. McAlpine, Anne-Marie Mes-Masson, Linda Mileshkin, Diane M. Provencher, Jan Pyman, Kurosh Rahimi, Simone M. Rowley, Carolina Salazar, Goli Samimi, Hugo Saunders, Timothy Semple, Ragwha Sharma, Alice J. Sharpe, Andrew N. Stephens, Niko Thio, Michelle C. Torres, Nadia Traficante, Zhongyue Xing, Magnus Zethoven, Yoland C. Antill, Clare L. Scott, Ian G. Campbell, Kylie L. Gorringe
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Whether mucinous ovarian carcinoma (MOC) arises from cells at the ovary or from metastases from other primary sites is an unanswered question. Here, Cheasley et al perform a genetic analysis of the disease, showing that MOC arises at the ovary.
Externí odkaz:
https://doaj.org/article/9047c1d475514bf5becaaddcde7c44d4
Autor:
Florian Weiland, Noor A. Lokman, Manuela Klingler-Hoffmann, Thomas Jobling, Andrew N. Stephens, Karin Sundfeldt, Peter Hoffmann, Martin K. Oehler
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Ovarian cancer is the most lethal gynecologic malignancy. Early detection would improve survival, but an effective diagnostic test does not exist. Novel biomarkers for early ovarian cancer diagnosis are therefore warranted. We performed intraoperativ
Externí odkaz:
https://doaj.org/article/e688cee0f3b749709580f0d24b9e20f1
Autor:
Sung-Woog Kang, Adam Rainczuk, Martin K. Oehler, Thomas W. Jobling, Magdalena Plebanski, Andrew N. Stephens
Publikováno v:
Diagnostics, Vol 11, Iss 6, p 1048 (2021)
Background: Despite substantial effort, there remains a lack of biomarker-based, clinically relevant testing for the accurate, non-invasive diagnostic or prognostic profiling of epithelial ovarian cancers (EOC). Our previous work demonstrated that wh
Externí odkaz:
https://doaj.org/article/23b809b8fffc472c8fb71a1244e5d58f
Autor:
Rachel, Delahunty, Linh, Nguyen, Stuart, Craig, Belinda, Creighton, Dinuka, Ariyaratne, Dale W, Garsed, Elizabeth, Christie, Sian, Fereday, Lesley, Andrews, Alexandra, Lewis, Sharne, Limb, Ahwan, Pandey, Joy, Hendley, Nadia, Traficante, Natalia, Carvajal, Amanda B, Spurdle, Bryony, Thompson, Michael T, Parsons, Victoria, Beshay, Mila, Volcheck, Timothy, Semple, Richard, Lupat, Kenneth, Doig, Jiaan, Yu, Xiao Qing, Chen, Anna, Marsh, Christopher, Love, Sanela, Bilic, Maria, Beilin, Cassandra B, Nichols, Christina, Greer, Yeh Chen, Lee, Susan, Gerty, Lynette, Gill, Emma, Newton, Julie, Howard, Rachel, Williams, Christie, Norris, Andrew N, Stephens, Erin, Tutty, Courtney, Smyth, Shona, O'Connell, Thomas, Jobling, Colin J R, Stewart, Adeline, Tan, Stephen B, Fox, Nicholas, Pachter, Jason, Li, Jason, Ellul, Gisela, Mir Arnau, Mary-Anne, Young, Louisa, Gordon, Laura, Forrest, Marion, Harris, Karen, Livingstone, Jane, Hill, Georgia, Chenevix-Trench, Paul A, Cohen, Penelope M, Webb, Michael, Friedlander, Paul, James, David, Bowtell, Kathryn, Alsop
Publikováno v:
Journal of Clinical Oncology. 40:2036-2047
PURPOSE Tubo-ovarian cancer (TOC) is a sentinel cancer for BRCA1 and BRCA2 pathogenic variants (PVs). Identification of a PV in the first member of a family at increased genetic risk (the proband) provides opportunities for cancer prevention in other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d66ca017250ec5b60c0dd8770470563
https://doi.org/10.1200/jco.21.02108
https://doi.org/10.1200/jco.21.02108
Autor:
Jacinta H, Martin, Riazuddin, Mohammed, Sarah J, Delforce, David A, Skerrett-Byrne, Celine Corbisier, de Meaultsart, Juhura G, Almazi, Andrew N, Stephens, Nicole M, Verrills, Evdokia, Dimitriadis, Yu, Wang, Eugenie R, Lumbers, Kirsty G, Pringle
Publikováno v:
Oncotarget. 13:587-599
Endometrial cancer is the most diagnosed gynecological malignancy. Despite numerous scientific advances, the incidence and mortality rate of endometrial cancer continues to rise. Emerging evidence suggests a putative role of the (pro)renin receptor (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1875042b56b40367e9eb3862a6a38d8c
https://doi.org/10.18632/oncotarget.28224
https://doi.org/10.18632/oncotarget.28224
Autor:
Noor A. Lokman, Carmela Ricciardelli, Andrew N. Stephens, Thomas W. Jobling, Peter Hoffmann, Martin K. Oehler
Publikováno v:
Diagnostics, Vol 11, Iss 1, p 69 (2021)
Ovarian cancer (OC) is commonly diagnosed at advanced stage when prognosis is poor. Consequently, there is an urgent clinical need to identify novel biomarkers for early detection to improve survival. We examined the diagnostic value of the calcium p
Externí odkaz:
https://doaj.org/article/24376952bc5b42eca92c86e8bddc56df
Autor:
Nirmala Chandralega Kampan, Apriliana Ellya Ratna Kartikasari, Cyril Deceneux, Mutsa Tatenda Madondo, Orla M. McNally, Katie Louise Flanagan, Norhaslinda A. Aziz, Andrew N. Stephens, John Reynolds, Michael A. Quinn, Magdalena Plebanski
Publikováno v:
Cancers
Volume 15
Issue 3
Pages: 667
Volume 15
Issue 3
Pages: 667
We hypothesised that the inclusion of immunosuppressive and inflammatory biomarkers in HGSOC patients would improve the sensitivity and specificity of the preoperative marker prediction of malignancy in patients with ovarian masses. We tested a panel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::809c9319f16dc197ea5079f5063dfa28