Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Andrew N Billin"'
Autor:
Shian-Huey Chiang, W Wallace Harrington, Guizhen Luo, Naphtali O Milliken, John C Ulrich, Jing Chen, Deepak K Rajpal, Ying Qian, Tiffany Carpenter, Rusty Murray, Robert S Geske, Stephen A Stimpson, Henning F Kramer, Curt D Haffner, J David Becherer, Frank Preugschat, Andrew N Billin
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134927 (2015)
Nicotinamide adenine dinucleotide (NAD+) is a key cofactor required for essential metabolic oxidation-reduction reactions. It also regulates various cellular activities, including gene expression, signaling, DNA repair and calcium homeostasis. Intrac
Externí odkaz:
https://doaj.org/article/6c250288d3cf48f0b41fe25918c4ad63
Autor:
Akshay Bareja, Jason A Holt, Guizhen Luo, Calvin Chang, Junyu Lin, Aaron C Hinken, Johannes M Freudenberg, William E Kraus, William J Evans, Andrew N Billin
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e90398 (2014)
Satellite cells are the chief contributor to skeletal muscle growth and regeneration. The study of mouse satellite cells has accelerated in recent years due to technical advancements in the isolation of these cells. The study of human satellite cells
Externí odkaz:
https://doaj.org/article/b59f032fb88a4b6cac5f3fde409dca6f
Autor:
Islam R. Younis, Brian J. Kirby, Andrew N. Billin, Deqing Xiao, Qinghua Song, Timothy R. Watkins, Ahmed A. Othman
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 3, Pp 536-547 (2023)
Abstract Cilofexor is a nonsteroidal farnesoid X receptor (FXR) agonist being evaluated for treatment of nonalcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC). This work characterized the pharmacokinetics, pharmacodynamic, safe
Externí odkaz:
https://doaj.org/article/69d9d611a3b5404a88365bc742848b86
Autor:
Mohamad Dandan, Julia Han, Sabrina Mann, Rachael Kim, Kelvin Li, Hussein Mohammed, Jen-Chieh Chuang, Kaiyi Zhu, Andrew N. Billin, Ryan S. Huss, Chuhan Chung, Robert P. Myers, Marc Hellerstein
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 3, Pp 100339- (2023)
Treatment with acetyl-CoA carboxylase inhibitors (ACCi) in nonalcoholic steatohepatitis (NASH) may increase plasma triglycerides (TGs), with variable changes in apoB concentrations. ACC is rate limiting in de novo lipogenesis and regulates fatty acid
Externí odkaz:
https://doaj.org/article/1b47be019904410e833c7ff617ad7ca5
Autor:
Ekaterina, Smirnova, Mark D, Muthiah, Nicole, Narayan, Mohamad S, Siddiqui, Puneet, Puri, Velimir A, Luketic, Melissa J, Contos, Michael, Idowu, Jen-Chieh, Chuang, Andrew N, Billin, Ryan S, Huss, Robert P, Myers, Sherry, Boyett, Mulugeta, Seneshaw, Hae-Ki, Min, Faridodin, Mirshahi, Arun J, Sanyal
Publikováno v:
Hepatology. 76:1811-1824
Bile acids are hepatic metabolites and have many properties considered to be relevant to the pathophysiology of NAFLD. Circulating levels of the intestinal microbiome-modified bile acid deoxycholate are increased in cirrhosis.To further elucidate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e9c204e496a981fe3b9eb32acb3053
https://doi.org/10.1002/hep.32568
https://doi.org/10.1002/hep.32568
Autor:
Islam R. Younis, Chia‐Hsiang Hsueh, Cara Nelson, Andrew N. Billin, Mun Sang Yue, Deqing Xiao, Timothy R. Watkins, Ahmed A. Othman
Publikováno v:
The Journal of Clinical Pharmacology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00dae8388bf225684316d45854d4615a
https://doi.org/10.1002/jcph.2260
https://doi.org/10.1002/jcph.2260
Autor:
Janani S. Iyer, Harsha Pokkalla, Charles Biddle-Snead, Oscar Carrasco-Zevallos, Mary Lin, Zahil Shanis, Quang Le, Dinkar Juyal, Maryam Pouryahya, Aryan Pedawi, Sara Hoffman, Hunter Elliott, Kenneth Leidal, Robert P. Myers, Chuhan Chung, Andrew N. Billin, Timothy R. Watkins, Murray Resnick, Katy Wack, Jon Glickman, Alastair D. Burt, Rohit Loomba, Arun J. Sanyal, Michael C. Montalto, Andrew H. Beck, Amaro Taylor-Weiner, Ilan Wapinski
Clinical trials in nonalcoholic steatohepatitis (NASH) require histologic scoring for assessment of inclusion criteria and endpoints. However, guidelines for scoring key features have led to variability in interpretation, impacting clinical trial out
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf4e90e1edfaeb039c78c57d3af13b08
https://doi.org/10.1101/2023.04.20.23288534
https://doi.org/10.1101/2023.04.20.23288534
Autor:
Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen‐Chieh Chuang, Julie Lin, Wen‐Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, Keyur Patel, Mazen Noureddin, Kris V. Kowdley, Aliya Gulamhusein, Christopher L. Bowlus, Ryan S. Huss, Robert P. Myers, Chuhan Chung, Andrew N. Billin
Publikováno v:
Hepatology (Baltimore, Md.), vol 77, iss 1
Background and aimsPruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood. Our aim was to evaluate serum IL-31 as a putative biomarker of pruritus in clinical trials
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62c7bfcc32e9d5782b1422ce63d86e65
https://escholarship.org/uc/item/038337xt
https://escholarship.org/uc/item/038337xt
Autor:
Eric Lawitz, G. Mani Subramanian, Zeid Kayali, Edward Gane, Mazen Noureddin, Vincent Wai-Sun Wong, Jun Xu, Stephen A. Harrison, Sergio Rojter, Eliza Harting, Mary E. Rinella, Robert Herring, C. Stephen Djedjos, Robert P. Myers, James F. Trotter, Saumya Jayakumar, Chuhan Chung, Magdy Elkhashab, Keyur Patel, Susan Greenbloom, Andrew N. Billin, Mitchell L. Shiffman, Michael S. Middleton, Bradley Freilich
Publikováno v:
Hepatology. 72:58-71
Background and aims We evaluated the safety and efficacy of cilofexor (formerly GS-9674), a small-molecule nonsteroidal agonist of farnesoid X receptor, in patients with nonalcoholic steatohepatitis (NASH). Approach and results In this double-blind,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6eff69ada0d0a838eb0aba7c234c31da
https://doi.org/10.1002/hep.31205
https://doi.org/10.1002/hep.31205
Autor:
Gabriel A. Kwong, Jay Luther, Wendy Winckler, Kathleen E. Corey, Ann K. Daly, Olivier Govaere, Quentin M. Anstee, V. Ratziu, Andrew N. Billin, Dina Tiniakos, Sarah Sherman, Louis Gelrud, Anna Zagorska, David G. Breckenridge, Fayçal Touti, Eric K. Huang, John T. Liles, Nil Gural, Sangeeta N. Bhatia, Jamie Bates, Andrew Warren, Sophie C. Cazanave, Maciej Pacula, Raymond T. Chung, Grant R. Budas, Mehar Cheema, Sabrina Ibarra
Publikováno v:
Science Translational Medicine. 13
Noninvasive detection of nonalcoholic steatohepatitis (NASH), the progressive form of nonalcoholic fatty liver disease, promises to improve patient screening, accelerate drug trials, and reduce health care costs. On the basis of protease dysregulatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4725c996a3088773ce242d38a7b04cf
https://doi.org/10.1126/scitranslmed.abe8939
https://doi.org/10.1126/scitranslmed.abe8939